Evidence-based thinking in clinical medicine has impacted greatly on the physician's approach to clinical care. Evidence-Based Dermatology introduces and encourages the concept of evidence-based patient care in dermatology. Incorporating a text that is much more than merely the summary of trial data, the authors worked to explore disease mechanisms and treatments in greater depth and detail in order to provide more insight for the reader. In addition to promoting the understanding of the evidence-based philosophy, the authors have focused on some of the fundamentals in dermatology that need to be approached differently. Issues such as the interpretation of clinical research, disease-oriented evidence versus patient-care evidence, and the use of placebo are examined.
This book introduces and encourages the concept of evidence-based pati ent care in dermatology. This is a growing area in dermatology, and th is work presents the ideology and methodology of critical thinking and also the available evidence across the field. Evidence-Based Dermatol ogy is aimed at both primary care physicians and dermatologists, encou raging disease management decisions to be based on the highest level o f evidence.
The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.
Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents. - A concise, yet inclusive review of effects of chemical exposure - Includes background on basic skin biology - Provides vital clinical reference for toxicologists in non-clinical settings
Exogenous Dermatoses presents a collection of comprehensive essays written by experts scientifically active in exogenous dermatoses research. Main areas covered include basic biological mechanisms, diagnostic methods, experimental investigations, and clinical aspects. The book will be an important source of reference for clinical and experimental dermatologists and scientists working with skin immunology and toxicology. It will also provide important information for cosmetic and pharmaceutical research.
Copper is increasingly recognized for its possible role in the prevention and moderation of disease, as well as the treatment of a number of conditions including skin irritation, sensitization, rheumatoid arthritis, and other inflammatory conditions. This source reviews general principles of percutaneous penetration to clarify the mechanisms contro
This book is a comprehensive reference on the methods available for the enhancement of percutaneous penetration. It examines a broad scope of chemical enhancers and various physical methods of enhancement. The range of chemicals discussed in this volume is unsurpassed anywhere in the literature. Scientists can find invaluable information in this single source on 95 percent of the enhancers being researched today! Each well-illustrated chapter is written by the world's leading authorities in the field. Introductory chapters outline the concept of penetration enhancement from first principles and provide a comprehensive classification of different types of enhancers.Chapters covering chemical enhancers are clear, concise, and easy to understand, even for novice readers in this field. The latest techniques by which drugs can be forced physically through the skin are also covered in depth. Equipment is detailed, typical drug candidates for the techniques are described, and the success to date is provided. Percutaneous Penetration Enhancers is the first book to present modern analytical techniques that have been used to assess penetration enhancement. The book also offers future perspectives for enhancers. New approaches and current limitations on knowledge and understanding of the topic are suggested. This timely source book is invaluable for clinical reference or for the design of scientific studies.
Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents. - A concise, yet inclusive review of effects of chemical exposure - Includes background on basic skin biology - Provides vital clinical reference for toxicologists in non-clinical settings
- Not only written by experts but the content of each of the chapters has also been peer-reviewed. - Presents a step-by-step approach to the treatment of chronic wounds. - For dermatologists, but also many other medical disciplines such as general practitioners and family physicians who also treat chronic wounds.
This publication serves as a guide to medical doctors and dentists in the evaluation and management of problems related to nickel allergy. The chemistry, analysis, and monitoring of nickel is explored. Recent advances in the immunology of nickel are dis-cussed. Additionally, sensitization assays for both humans and animals are presented. The clinical, genetic, and epidemiologic as-pects of nickel sensitization and nickel dermatitis are explained. Social and demographic aspects of nickel contact allergy are dis-cussed, as well as the topic of the nickel dermatitis as a pre-ventable health problem.
Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students.
This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.
This revised and updated mini-atlas is a concise survey of the most commonly encountered dermatologic and venereologic patterns. The text focuses on clinical features and includes therapeutic suggestions, as well as numerous tables summarizing essential information.
Human health is facing unprecedented threats from global environmental change. This book describes the challenges and opportunities to safeguard health.
Long established as a trusted core text for pharmaceutics courses, this gold standard book is the most comprehensive source on pharmaceutical dosage forms and drug delivery systems available today. Reflecting the CAPE, APhA, and NAPLEX® competencies, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems covers physical pharmacy, pharmacy practice, pharmaceutics, compounding, and dosage forms, as well as the clinical application of the various dosing forms in patient care. This Tenth Edition has been fully updated to reflect new USP standards and features a dynamic new full color design, new coverage of prescription flavoring, and increased coverage of expiration dates.
The first edition of Making Healthy Places offered a visionary and thoroughly researched treatment of the connections between constructed environments and human health. Since its publication over 10 years ago, the field of healthy community design has evolved significantly to address major societal problems, including health disparities, obesity, and climate change. Most recently, the COVID-19 pandemic has upended how we live, work, learn, play, and travel. In Making Healthy Places, Second Edition: Designing and Building for Well-Being, Equity, and Sustainability, planning and public health experts Nisha D. Botchwey, Andrew L. Dannenberg, and Howard Frumkin bring together scholars and practitioners from across the globe in fields ranging from public health, planning, and urban design, to sustainability, social work, and public policy. This updated and expanded edition explains how to design and build places that are beneficial to the physical, mental, and emotional health of humans, while also considering the health of the planet. This edition expands the treatment of some topics that received less attention a decade ago, such as the relationship of the built environment to equity and health disparities, climate change, resilience, new technology developments, and the evolving impacts of the COVID-19 pandemic. Drawing on the latest research, Making Healthy Places, Second Edition imparts a wealth of practical information on the role of the built environment in advancing major societal goals, such as health and well-being, equity, sustainability, and resilience. This update of a classic is a must-read for students and practicing professionals in public health, planning, architecture, civil engineering, transportation, and related fields.
-- Perfect for the student, primary care practitioner, and pharmacist who needs both basic and clinical information to apply therapeutics-- A new overview chapter -- plus practical steps required for optimal therapeutic decisions-- Coverage of newly emerging advances in therapeutics-- A new look at cost/benefit analysis of therapy-- Increased emphasis on drug interactions, and much more.
The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.
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