This symposium was established in 1976 for the purpose of bringing to gether once every two or three years, active investigators in the fore front of contemporary immunology, to present their findings and to discuss their significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the under standing of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptides which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has finally occurred and many applications of these peptides are now being realized. The main symposia topics of the fourth symposium were: T-cell recognition of proteins, structure and function of the T-cell receptor, presentation of protein antigens, recycling and activation of membrane receptor molecules, Ir-gene control of T-cell responses and methods of cell separation. The molecular features recognized by antibodies on proteins were the first immune recognition sites to be local ized and confirmed by synthetic peptides. The complete antigenic structures of several proteins have been defined, and individual antigenic sites have been described on many more proteins. More recently, major breakthroughs have been reported in the immune recognition of proteins by T cells.
Severe and persistent mental illnesses are among the most pressing health and social problems in contemporary America. Recent estimates suggest that more than three million people in the U.S. have disabling mental disorders. The direct and indirect costs of their care exceed 180 billion dollars nationwide each year. Effective treatments and services exist, but many such individuals do not have access to these services because of limitations in mental health and social policies. For nearly two centuries Americans have grappled with the question of how to serve individuals with severe disorders. During the second half of the twentieth century, mental health policy advocates reacted against institutional care, claiming that community care and treatment would improve the lives of people with mental disorders. Once the exclusive province of state governments, the federal government moved into this policy arena after World War II. Policies ranged from those focused on mental disorders, to those that focused more broadly on health and social welfare. In this book, Gerald N. Grob and Howard H. Goldman trace how an ever-changing coalition of mental health experts, patients' rights activists, and politicians envisioned this community-based system of psychiatric services. The authors show how policies shifted emphasis from radical reform to incremental change. Many have benefited from this shift, but many are left without the care they require.
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