Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students.
Nucleotide Sequences 1986/1987, Volume VII: Structural RNA, Synthetic, and Unannotated Sequences presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into three sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.
Nucleotide Sequences 1986/1987, Volume I: Primates presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into one section, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.
Te Linde’s Operative Gynecology has been the premier text in the field of gynecologic surgery for more than 60 years. This text covers all of the aspects of gynecologic surgery – from the most general topics of surgical ethics to instruction on detailed surgical procedures. General background/pathology for surgical problems is covered as are patient/treatment selection, step-by-step surgical techniques and post-operative concerns.
The 1950's saw a major revolution on the movie front. In order to combat TV, the size of movies screens was changed forever. Unfortunately, there was no standard agreement as to what dimensions, the preferred new sized screen should be.
Hollywood's Golden Era? I'd pick the period from 1939 through 1960. Here are 144 classic movies from this Golden Age of the Cinema, ranging (alphabetically) from "The Admiral Was a Lady" to "You Were Never Lovelier". Other films discussed in comprehensive detail (and with full background and release information) in this book include "The Adventures of Mark Twain", "The Chase", "Daisy Kenyon", "The Ghost of Frankenstein", "Humoresque", "In Old California", "Joan of Paris", "Letter from an Unknown Woman", "Magic Town", "Nightmare Alley", The Paradine Case", "Roughly Speaking", "The Scarlet Claw", "Where the Sidewalk Ends" and "You'll Never Get Rich".
More than 50 of Hollywood's most famous movies are examined in detail in this book, which provides full cast and production credits, release dates, background information, DVD suppliers, plus up-to-date assessments and reviews. This information not only covers almost everything you would want to know about some of your favorite movies, but guides you towards further classic films you might enjoy! To name just twenty of the more than fifty titles, they include An American in Paris, The Apartment, The Caine Mutiny, Casablanca, China Seas, Duck Soup, From Here To Eternity, Gone With The Wind, The Greatest Show On Earth, If I Had a Million, In Old Chicago, It Happened One Night, Laura, Out of the Past, The Palm Beach Story, the Picture of Dorian Gray, A Place in the Sun, two versions of State Fair, The Wizard of Oz, Wonder Bar, and Yankee Doodle Dandy.
Knowledge in the field of allergic contact dermatitis has grown to a great extent, due to recent advances in the chemical, immunological and clinical fields. These advances include the improved techniques of patch testing and prick testing, e.g. additional tests such as open, semi-open, repeated open application test (ROAT) and use tests, photopatch tests, atopy patch tests and provocative tests. Further, due to the ongoing changes in our environment, the series of patch tests – the so-called standards – are also regularly renewed. This new edition is completely revised, updated and expanded, with more colour illustrations. It is a universally useful and superb guide in the management of positive and negative patch test and prick test reactions, for all practicing dermatologists, from the beginner to the well-trained expert.
This three-in-one holiday gift set is the perfect gift for any baseball fan this season. Each with its own unique story, these books will thrill any fan of America’s favorite pastime. The set includes class tales (At the Old Ballgame: Stories From Baseball's Golden Era), scandals (Mudville Madness: Fabulous Feats, Belligerent Behavior, and Erratic Episodes on the Diamond), and a unique portrait of baseball’s early days (Death Row All Stars: A Story of Baseball, Corruption, and Murder). That’s three strikes for this set!
Nucleotide Sequences 1986/1987, Volume IV: Plants and Organelles presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences of the U.S National Institutes of Health. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.
The first full-scale introduction to and history of cognitive science. An interdisciplinary study of the nature of knowledge by the noted cognitive scientist and author of Frames of Mind.
Nucleotide Sequences 1986/1987, Volume V: Bacteria and Bacteriophage presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.
Copper is increasingly recognized for its possible role in the prevention and moderation of disease, as well as the treatment of a number of conditions including skin irritation, sensitization, rheumatoid arthritis, and other inflammatory conditions. This source reviews general principles of percutaneous penetration to clarify the mechanisms contro
This third collection of widescreen wonders photographed in CinemaScope, focuses on such popular movies as "Love Is a Many-Splendored Thing," "Cleopatra," "Three Coins in the Fountain," "Bus Stop," "There's No Business Like Show Business," "The Seven Year Itch," "Let's Make Love," "Peyton Place," "North to Alaska," "The Longest Day," "The Eddy Duchin Story," "Far from the Madding Crowd," "The Man in the Gray Flannel Suit," "The Helen Morgan Story," "A Star Is Born" and "2001: A Space Odyssey.
How does learning transform us biologically? What learning processes do we share with bacteria, jellyfish and monkeys? Is technology impacting on our evolution and what might the future hold for the learning brain? These are just some of the questions Paul Howard-Jones explores on a fascinating journey through 3.5 billion years of brain evolution, and discovers what it all means for how we learn today. Along the way, we discover how the E. coli in our stomachs learn to find food why a little nap can help bees find their way home the many ways that action, emotion and social interaction have shaped our ability to learn the central role of learning in our rise to top predator. An accessible writing style and numerous illustrations make Evolution of the Learning Brain an enthralling combination of biology, neuroscience and educational insight. Howard-Jones provides a fresh perspective on the nature of human learning that is exhaustively researched, exploring the implications of our most distant past for twenty-first-century education.
The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.
Never before has a comprehensive history of the pancreas like History of the Pancreas been published. It not only is a historical review of the science of medicine, it is liberally interspersed with anecdotal vignettes of the researchers who have worked on this organ. Much of it, such as the discovery of the duct of Wirsüng, of the islets of Langerhans, of insulin, gastrin and their tumors, reads like the adverture, which it is. This book, divided into 14 chapters, is written in a narrative style and is easily readable, as glimpses of the investigators, those who failed as well as those who succeeded, adds both perspective and human interest. Each chapter is completely referenced, totaling over 1500 references. As a reference book for students, teachers, investigators, writers, its detailed hjistorical documentation is unique. From the pre-Christian era of Asia Minor, to Greece, Rome, Europe and America, to the explosive progress in Japan, the history is there. History of the Pancreas: Mysteries of a Hidden Organ fills a gap.
Many otherwise strong doctoral students get stuck at the dissertation stage, but this trusty guide takes students from the early planning phase to finishing the final draft. It contains straightforward advice for each stage of the dissertation process: selecting a chair, completing the literature review, developing a hypothesis, selecting a study sample and appropriate measures, managing and analyzing both quantitative and qualitative data, establishing good writing habits, and overcoming obstacles to completing the dissertation on schedule. Practical guidelines, tips and strategies, and action steps checklists in each chapter make this a handy pocket guide for students as well as advisors seeking a comprehensive, unintimidating road map to the social work dissertation.
This book introduces and encourages the concept of evidence-based pati ent care in dermatology. This is a growing area in dermatology, and th is work presents the ideology and methodology of critical thinking and also the available evidence across the field. Evidence-Based Dermatol ogy is aimed at both primary care physicians and dermatologists, encou raging disease management decisions to be based on the highest level o f evidence.
Over 60 great film musicals from Hollywood's major studios are given detailed treatment, while hundreds more are briefly noted in this comprehensive guide to the best of America's vintage movie musical classics that are now available on DVD.
The maJonty of the chapters in this volume are structured to include a balance between literature review, original data, and synthesis. The research approaches taken by the authors are generallyof two kinds. One centers on the long-term, in-depth study of a single species in which many aspects of its natural history are examined in detail. The other is a comparative one which involves investigating particular questions by examining species or by comparing groups of species that may include taxonomic andjor ecological affinities. Most of the chapters concern obvious aspects of breeding behavior including habitat selection, the effects of age on breeding, communication, mating systems, synchrony of breeding activities, development of behavior, prefledging parental care, and postfledging parental care. Of these topics, many relate directly to the advantages and disadvantages of coloniality-a conspicuous behavior pattern in marine birds. As such, they provide para.picuou for the further study of coloniality and the social behaviorof many other animals. Other important areas of marine bird breeding behavior (such as courtship behavior, antipredator behavior, information transfer) have not been included because of space limitations. Since man's encroachment on the seashore and continental shelf poses certain threats to marine birds, a volume elucidating various aspects of their biology has multiple uses. As weil as being of value to ornithologists, the volume should be useful to managers involved with coastal planning.
This publication serves as a guide to medical doctors and dentists in the evaluation and management of problems related to nickel allergy. The chemistry, analysis, and monitoring of nickel is explored. Recent advances in the immunology of nickel are dis-cussed. Additionally, sensitization assays for both humans and animals are presented. The clinical, genetic, and epidemiologic as-pects of nickel sensitization and nickel dermatitis are explained. Social and demographic aspects of nickel contact allergy are dis-cussed, as well as the topic of the nickel dermatitis as a pre-ventable health problem.
In one convenient source, this book provides a broad, detailed, and cohesive overview of seizure disorders and contemporary treatment options. For this Fifth Edition, the editors have replaced or significantly revised approximately 30 to 50 percent of the chapters, and have updated all of them. Dr. Wyllie has invited three new editors: Gregory Cascino, MD, FAAN, at Mayo Clinic, adult epileptologist with special expertise in neuroimaging; Barry Gidal, PharmD, at University of Wisconsin, a pharmacologist with phenomenal expertise in antiepileptic medications; and Howard Goodkin, MD, PhD, a pediatric neurologist at the University of Virginia. A fully searchable companion website will include the full text online and supplementary material such as seizure videos, additional EEG tracings, and more color illustrations.
Merging cognitive science with educational agenda, Gardner makes an eloquent case for restructuring our schools by showing just how ill-suited our minds and natural patterns of learning are to the prevailing modes of education. This reissue includes a new introduction by the author.
A composer and lyricist of enormous innovation and influence, Marc Blitzstein remains one of the most versatile and fascinating figures in the history of American music, his creative output running the gamut from films scores and Broadway operas to art songs and chamber pieces. A prominent leftist and social maverick, Blitzstein constantly pushed the boundaries of convention in mid-century America in both his work and his life. Award-winning music historian Howard Pollack's new biography covers Blitzstein's life in full, from his childhood in Philadelphia to his violent death in Martinique at age 58. The author describes how this student of contemporary luminaries Nadia Boulanger and Arnold Schoenberg became swept up in the stormy political atmosphere of the 1920s and 1930s and throughout his career walked the fine line between his formal training and his populist principles. Indeed, Blitzstein developed a unique sound that drew on everything contemporary, from the high modernism of Stravinsky and Hindemith to jazz and Broadway show tunes. Pollack captures the astonishing breadth of Blitzstein's work--from provocative operas like The Cradle Will Rock, No for an Answer, and Regina, to the wartime Airborne Symphony composed during his years in service, to lesser known ballets, film scores, and stage works. A courageous artist, Blitzstein translated Bertolt Brecht and Kurt Weill's The Threepenny Opera during the heyday of McCarthyism and the red scare, and turned it into an off-Broadway sensation, its "Mack the Knife" becoming one of the era's biggest hits. Beautifully written, drawing on new interviews with friends and family of the composer, and making extensive use of new archival and secondary sources, Marc Blitzstein presents the most complete biography of this important American artist.
The early, organ-specific diagnosis of malignancy continues to be a major unmet medical need. Clearly the ability to establish an early diagnosis of cancer is dependent upon an intimate knowledge of the cancer's biology, which if understood at the molecular level should identify key diagnostic and therapeutic manipulation points. Advances in recombinant gene technology have provided significant understanding of the mechanisms of action of oncogenic viruses, as well as of cancer-associated genomic sequences (onco genes). This text will explore the known molecular genetic, biolog ical, and clinical knowledge of selected human neoplasms that demonstrate association with suspected oncogenic virus and those cytogenetic alterations that either cause or are caused by oncogene activation. The text first reviews the cytogenetics of human cancers link ing classical cytogenetics and molecular genetics. Avery A. Sand berg (Roswell Park Memorial Institute, Buffalo, New York) reviews the leukemias and lymphomas, followed by S. Pathak (M. D. Anderson Hospital and Tumor Institute, Houston, Texas), who reviews solid tumors. Functional consideration of oncogenes is highlighted by Keith C. Robbins and Stuart A. Aaronson (NO, Bethesda, Maryland) through their description of the v-sis locus sis and its gene product p.28 ; a protein that closely resembles human platelet-derived growth factor (PDGF).
This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.
Gathered in this large volume paperback are some of Hollywood's best loved and most famous movies. In addition to the many film classics, however, the author has included a number of equally entertaining films that deserve to be better known. Many of these movies are now available on DVD. Full credits and detailed reviews are provided for over a hundred of these classic films. Over two hundred more movies are represented by short reviews. Many of the reviews contain DVD details. Of course, not all classic movies have surfaced on DVD to date, but they are being issued at the rate of around forty a month! If you love classic movies, this book will provide an invaluable guide to some of the enjoyable films that are now available (and also, of course, some of the disappointing films that you might wisely avoid).
Leading American psychologist and educator Howard Gardner has assembled his most important writings about education. Spanning over thirty years, this collection reveals the thinking, the concepts and the empirical research that have made Gardner one of the most respected and cited educational authorities of our time. Trained originally as a psychologist at Harvard University, Howard Gardner begins with personal sketches and tributes to his major teachers and mentors. He then presents the work for which he is best-known – the theory of multiple intelligences – including a summary of the original theory and accounts of how it has been updated over the years. Other seminal papers featured include: education in the arts the nature of understanding powerful ways in which to assess learning broad statements about the educational enterprise how education is likely to evolve in the globalised world of the twenty-first century.
This book illustrates in detail the range of understandings of the human condition in New Testament times and remedies for ills that prevailed when Jesus and the apostles were spreading the Christian message and launching Christian communities in the Graeco-Roman world.
Based on extensive research, this provocative volume explores how schools are places where racial conflicts often remain hidden at the expense of a healthy school climate and the well-being of other students of colour. Most schools fail to act on racial microaggressions because the stress of negotiating such conflicts is extremely high due to fears of incompetence, public exposure, and accusation. Instead of facing these conflicts head on, schools perpetuate a set of avoidance or coping strategies. The author of this much-needed book uncovers how racial stress undermines student achievement. Students, educators, and social service support staff will find workable strategies to improve their racial literacy skills to read, recast, and resolve racially stressful encounters when they happen. This book features: a model that applies culturally relevant behavioural stress management strategies to problem-solve racial stress in schools; examples demonstrating workable solutions relevant within predominantly White schools for students, parents, teachers, and adminsitrators; measurable outcomes and strategies for developing racial literacy skills that can be integrated into the K - 12 curriculum and teacher professional development; and teaching and leadership skills that will create a more tolerant and supportive school environment for all students.
Nucleotide Sequences 1986/1987, Volume III: Other Vertebrates and Invertebrates presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into three sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences of the U.S National Institutes of Health. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.
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