The initial impetus to create a work combining aspects of cel lular immunology with their clinical applications grew from the ed itors' discussions of the area's needs with many of the leaders in the field over a period of time. From the nucleus of ideas that emerged, we have here attempted to create a unified and inte grated coverage of the rapidly growing field of cellular immunology research and to trace out-from what seems at times a genuine plethora of important new findings-the many and often impor tant clinical implications. Because of this approach, the chapters of Clinical Cellular Im munology attempt to be more than critical reviews of research and clinical data, going beyond analysis to synthesize working hypotheses about the functional meaning of cellular immunological phenomena and their likely clinical significance. To accomplish this undertaking, the text begins first with a consid eration of the molecular aspects of antigen recognition (Luderer and Harvey) and of the ensuing regulatory program initiation (Fathman). Then, the functional subsets oflymphocytes as they in teract to produce and control the developing immune response are explored in detail (Sigel et a1.), followed by a unique analytical dis section of the action of immunosuppressive agents on the sundry inductive and regulatory immunologic pathways (Sigel et al.). A majority of the data and conclusions drawn by the authors in the previous chapters arise from work on murine systems, al though wherever appropriate, human data has been introduced.
Mass Violence and the Self explores the earliest visual and textual depictions of personal suffering caused by the French Wars of Religion of 1562–98, the Fronde of 1648–52, the French Revolutionary Terror of 1793–94, and the Paris Commune of 1871. The development of novel media from pamphlets and woodblock printing to colored lithographs, illustrated newspapers, and collodion photography helped to determine cultural, emotional, and psychological responses to these four episodes of mass violence. Howard G. Brown's richly illustrated and conceptually innovative book shows how the increasingly effective communication of the suffering of others combined with interpretive bias to produce what may be understood as collective traumas. Seeing these responses as collective traumas reveals their significance in shaping new social identities that extended beyond the village or neighborhood. Moreover, acquiring a sense of shared identity, whether as Huguenots, Parisian bourgeois, French citizens, or urban proletarians, was less the cause of violent conflict than the consequence of it. Combining neuroscience, art history, and biography studies, Brown explores how collective trauma fostered a growing salience of the self as the key to personal identity. In particular, feeling empathy and compassion in response to depictions of others' emotional suffering intensified imaginative self-reflection. Protestant martyrologies, revolutionary "autodefenses," and personal diaries are examined in the light of cultural trends such as the interiorization of piety, the culture of sensibility, and the birth of urban modernism to reveal how representations of mass violence helped to shape the psychological processes of the self.
Filled with critical insights, Brown's revisionist study utilizes an impressive array of archival sources, some only recently cataloged, to support his thesis that the French Revolution survived until 1802 and the Consulate regime.... This volume should be a priority for all historians and serious students interested in modern French history. Summing Up: Essential."--Choice "What Brown has done is to put all historians of the French Revolution in his debt by the thoroughness with which he explores an important aspect of the complex and interrelated problems posed by any attempt to create a new social and moral order based on principles that could prove to be self-contradictory and were neither understood nor welcomed by a substantial proportion of the population."--English Historical Review "This is one of the most important pieces of scholarship on the French Revolution since the 1989 bicentennial."--David Bell, Johns Hopkins University For two centuries, the early years of the French Revolution have inspired countless democratic movements around the world. Yet little attention has been paid to the problems of violence, justice, and repression between the Reign of Terror and the dictatorship of Napoleon Bonaparte. In Ending the French Revolution, Howard Brown analyzes these years to reveal the true difficulty of founding a liberal democracy in the midst of continual warfare, repeated coups d'état, and endemic civil strife. By highlighting the role played by violence and fear in generating illiberal politics, Brown speaks to the struggles facing democracy in our own age. The result is a fundamentally new understanding of the French Revolution's disappointing outcome. Howard G. Brown, Professor of History at Binghamton University, State University of New York, is the author of War, Revolution, and the Bureaucratic State: Politics and Army Administration in France, 1791-1799 and coeditor of Taking Liberties: Problems of a New Order from the French Revolution to Napoleon. Winner of the American Historical Association's 2006 Leo Gershoy Award and the University of Virginia's 2004 Walker Cowen Memorial Prize for an outstanding work of scholarship in eighteenth-century studies
Coconut oil and other alternative oils are a hot topic these days in the cooking world, especially after the news of extra-virgin olive oil fraud broke out, as described in Extra Virginity. More and more people are becoming wary of the typical processed and refined cooking oils on the market, and they are beginning to use unprocessed, unrefined alternative oils for their cooking and baking. However, not everyone knows how to effectively incorporate them into their cooking. That's where The Big Book of Healthy Cooking Oils by Lisa Howard, creator of TheCulturedCook.com and renowned culinary speaker and instructor, comes in. This incredible collection of over 85 recipes harnesses the different attributes of each oil's distinct flavor, ideal cooking temperature and beneficial nutrients. Readers will knowledgeably create delicious and healthy meals, snacks and desserts, such as Toasted Wild Rice with Coconut & Brazilian Nut Pesto Chicken using coconut oil, Wild Salmon Cakes with Sun-Dried Tomatoes using avocado oil and Pear, Sage & Cheddar Fritatta using pecan oil. If you are looking for a guide to using healthy oils in your cooking and baking, you will love The Big Book of Healthy Cooking Oils.
Issues relating to the high-K gate dielectric are among the greatest challenges for the evolving International Technology Roadmap for Semiconductors (ITRS). More than just an historical overview, this book will assess previous and present approaches related to scaling the gate dielectric and their impact, along with the creative directions and forthcoming challenges that will define the future of gate dielectric scaling technology. Topics include: an extensive review of Moore's Law, the classical regime for SiO2 gate dielectrics; the transition to silicon oxynitride gate dielectrics; the transition to high-K gate dielectrics (including the drive towards equivalent oxide thickness in the single-digit nanometer regime); and future directions and issues for ultimate technology generation scaling. The vision, wisdom, and experience of the team of authors will make this book a timely, relevant, and interesting, resource focusing on fundamentals of the 45 nm Technology Generation and beyond.
The flaws in today's healthcare systems and practices are well-documented: millions remain far from optimal health due to a variety of psychological and social factors; large numbers of patients do not fully cooperate with medical advice; errors in medical decision-making -- some stemming from flaws in interpersonal relations -- regularly lead to needless suffering and death. Further, the effects of emotions, personality, and motivation on healing are not well incorporated into traditional medical care. The Oxford Handbook of Health Psychology compiles the most relevant scholarship from psychology, medicine, and public health to offer a thorough and authoritative model of the biopsychosocial approach to health. A collection of international contributors addresses all relevant concepts in this model, including its applications to health promotion, health behavior change, and treatment.
Despite what many people might think, a gluten-free diet can be just as unhealthy as the standard American diet (also known as SAD). This is due to the fact that most store-bought gluten-free items—as well as many recipes in gluten-free cookbooks—include refined sugar, starches, fillers, and other nutrient-dead foods. You’re likely familiar with some of these ingredients already: White rice flour Potato starch Xantham gum Cornstarch Tapioca flour Guar gum DIV /divDIVHealthier Gluten-Free is a unique cookbook that educates the reader on how to cook without nutritionally deficient ingredients like xanathan gum and starchy flours and instead prepare recipes and meals that focus on flavorful, health-full, naturally gluten-free ingredients, such as: /div Healthy whole grains (brown rice, quinoa, buckwheat, etc.—all of which are gluten-free) Healthy flours (almond flour, coconut flour, millet flour) Healthy fats and binding agents (coconut oil, nut butters, eggs, avocado) Healthy sweeteners (maple syrup, molasses, honey) An abundance of produce and lean meats DIV/divDIVIt’s clean eating, gluten-free style. /div
Table of Contents: Abraham Lincoln, Adventures of Marco Polo, Affaire Nina B., All Quiet on the Western Front, Anastasia, Anna Boleyn, Assassination of Jesse James, Belle Starr, The Big Knife, Bonnie Prince Charlie, Boys Town, Brigham Young, Butch and Sundance: The Early Days, Captain Fly-By-Night, Carry On Dick, Charge of the Light Brigade, Children of Eve, Cleopatra, The Court Martial of Billy Mitchell, The Cruel Sea, Day of the Locust, Destination Unknown, Disraeli, Divine Lady, The Devil's Brigade, The Devil's Needle, Don't Lose Your Head, Dr. Jekyll and Mr. Hyde, End of the Trail, The Enforcer, Excalibur, Fangs of Destiny, Great Gatsby, Great Dictator, Great Moment, Hawk of the Hills, Helen of Troy, Humanity and Paper Balloons, If I Were King, The Informer, In Old Arizona, In Old Chicago Is Paris Burning?, James Dean Story, The Jayhawkers, Joyeux Noel, King of Kings, The Lady of the Lake, The Law and Outlaw, Lives of a Bengal Lancer, The Lawless Breed, Man with the Green Carnation, Marco Polo, etc. etc.
Nucleotide Sequences 1986/1987, Volume V: Bacteria and Bacteriophage presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.
Energy is an enabler of – and a constraint on – military power. Operational Energy provides military officers with knowledge and skills to plan effectively for the operational energy needs of their forces. Operational energy is the energy used to train, move, and sustain military forces and weapons platforms for military operations. Energy has always played a role in battlefield outcomes. Over the twentieth and early twenty-first centuries the importance of energy in warfighting has grown. Today, energy is a critical pillar of national defense and a major factor in military power. In modern warfare, attaining energy superiority over one’s adversaries is a critical condition for success on the battlefield. Operational energy planning is an integral part of all combat and regular operations. Operational Energy is a valuable and extensive resource for students of US Department of Defense courses in military universities, colleges, and academic training programs; scholars of geopolitics, and researchers on US and global energy security. Operational Energy is to date the only textbook on defense energy planning, analysis, and strategy. It examines in detail fuel types, geopolitical issues, energy supply risks, market economic factors, and technology, presenting topics for future research. It also includes chapter summaries, main points for study, and case studies.
The leading reference in the field of geriatric care, Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 8th Edition, provides a contemporary, global perspective on topics of importance to today's gerontologists, internal medicine physicians, and family doctors. An increased focus on frailty, along with coverage of key issues in gerontology, disease-specific geriatrics, and complex syndromes specific to the elderly, makes this 8th Edition the reference you'll turn to in order to meet the unique challenges posed by this growing patient population. - Consistent discussions of clinical manifestations, diagnosis, prevention, treatment, and more make reference quick and easy. - More than 250 figures, including algorithms, photographs, and tables, complement the text and help you find what you need on a given condition. - Clinical relevance of the latest scientific findings helps you easily apply the material to everyday practice. - A new chapter on frailty, plus an emphasis on frailty throughout the book, addresses the complex medical and social issues that affect care, and the specific knowledge and skills essential for meeting your patients' complex needs. - New content brings you up to date with information on gerontechnology, emergency and pre-hospital care, HIV and aging, intensive treatment of older adults, telemedicine, the built environment, and transcultural geriatrics. - New editor Professor John Young brings a fresh perspective and unique expertise to this edition.
In one convenient source, this book provides a broad, detailed, and cohesive overview of seizure disorders and contemporary treatment options. For this Fifth Edition, the editors have replaced or significantly revised approximately 30 to 50 percent of the chapters, and have updated all of them. Dr. Wyllie has invited three new editors: Gregory Cascino, MD, FAAN, at Mayo Clinic, adult epileptologist with special expertise in neuroimaging; Barry Gidal, PharmD, at University of Wisconsin, a pharmacologist with phenomenal expertise in antiepileptic medications; and Howard Goodkin, MD, PhD, a pediatric neurologist at the University of Virginia. A fully searchable companion website will include the full text online and supplementary material such as seizure videos, additional EEG tracings, and more color illustrations.
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