Hiroyuki Kitagawa's Books

The Unnormalized Relational Data Model

For Office Form Processor Design

By: Hiroyuki Kitagawa,Tosiyasu L. Kunii

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The Unnormalized Relational Data Model

For Office Form Processor Design

By: Hiroyuki Kitagawa,Tosiyasu L. Kunii

Computer Science Workbench is a monograph series which will provide you with an in-depth working knowledge of current developments in computer technology. Every volume in this series will deal with a topic of importance in computer science and elaborate on how you yourself can build systems related to the main theme. You will be able to develop a variety of systems, including computer software tools, computer graphics, computer animation, database management systems, and computer-aided design and manufacturing systems. Computer Science Workbench represents an important new contribution in the field of practical computer technology. TOSIYASU L. KUNII Preface The evolution of database systems research is itself a story. Long after the emergence of systems derived from practical applications, Codd's relational data model has gradually occupied the theoretical domain of database systems and is moving into the realms of practical use. Certainly, the theoretical foundation makes database design, validation, and testing easier. However, Cod d's model allows only fiat tables to be handled, while most business and engineering data in practice are in nested table forms. Thus, a recent major obstacle in database systems development is the large gap between the theory and the practice.

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Page Count

172

Publisher

Springer Science & Business Media

Published Date

ISBN 10

4431680993

ISBN 13

9784431680994

Fracture Nanomechanics

By: Takayuki Kitamura,Hiroyuki Hirakata,Takashi Sumigawa,Takahiro Shimada

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Fracture Nanomechanics

By: Takayuki Kitamura,Hiroyuki Hirakata,Takashi Sumigawa,Takahiro Shimada

Materials of micro-/nanometer dimensions have aroused remarkable interest, motivated by the diverse utility of unconventional mechanical and electronic properties distinguished from the bulk counterpart and various industrial applications such as electronic/optic devices and MEMS/NEMS. The size of their elements is now, ultimately, approaching nano

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Page Count

329

Publisher

CRC Press

Published Date

ISBN 10

9814669059

ISBN 13

9789814669054

Japanese Dentition: Anthropology And History

By: Eisaku Kanazawa,Hiroyuki Yamada

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Japanese Dentition: Anthropology And History

By: Eisaku Kanazawa,Hiroyuki Yamada

This book introduces the achievements of dental anthropology research in Japan to the people in the world. It starts with the tooth morphology of the people in the Paleolithic Period about 20,000 years ago. Then it goes through Jomon Age and Yayoi Age when the admixture of the people happened. Here the difference of the tooth shape between those two human groups is emphasized. After these ages, Japanese teeth were not the same from age to age influenced by the environment. In the current age of Japan, topics such as third molar agenesis, change of eruption time of the first permanent teeth, mandibular torus, and high canine are discussed. These abnormal conditions in Japan also reflect the characteristic features of Japanese history and culture.

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Page Count

214

Publisher

World Scientific

Published Date

ISBN 10

9811219699

ISBN 13

9789811219696

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

By: Akihiro Hirakawa,Hiroyuki Sato,Takashi Daimon,Shigeyuki Matsui

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Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

By: Akihiro Hirakawa,Hiroyuki Sato,Takashi Daimon,Shigeyuki Matsui

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of adaptive dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with advanced materials for designing, conducting, monitoring, and analyzing adaptive dose-finding trials. The topics in the book are mainly related to cancer clinical trials, but many of those topics are potentially applicable or can be extended to trials for other diseases. The focus is mainly on model-based dose-finding methods for two kinds of phase I trials. One is clinical trials with combinations of two agents. Development of dose-finding methods for two-agent combination trials requires reasonable models that can adequately capture joint toxicity probabilities for two agents, taking into consideration possible interactions of the two agents on toxicity probability such as synergistic or antagonistic effects. Another is clinical trials for evaluating both efficacy and toxicity outcomes in single- and two-agent combination trials. These methods are often applied to the phase I trials including MTAs because the toxicity and efficacy for a MTA does not monotonically increase with dose, but the efficacy often increases initially with the dose and then plateaus. Successful software implementations for several dose-finding methods are introduced in the book, and their operating characteristics in practice are discussed. Recent advance of the adaptive dose-finding methods in drug developments are also provided.

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Page Count

100

Publisher

Springer

Published Date

ISBN 10

4431555730

ISBN 13

9784431555735

Protein Targeting with Small Molecules

Chemical Biology Techniques and Applications

By: Hiroyuki Osada

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Protein Targeting with Small Molecules

Chemical Biology Techniques and Applications

By: Hiroyuki Osada

Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides. Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications: Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules

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Page Count

310

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470495006

ISBN 13

9780470495001

Checking Theory and Grammatical Functions in Universal Grammar

By: Hiroyuki Ura

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Checking Theory and Grammatical Functions in Universal Grammar

By: Hiroyuki Ura

Ura demonstrates that his theory of multiple feature-checking, an extension of Chomsky's Agr-less checking theory, gives a natural explanation for a wide range of data drawn from a variety of languages in a very consistent way with a limited set of parameters.

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Page Count

337

Publisher

Oxford University Press

Published Date

ISBN 10

0195353404

ISBN 13

9780195353402

Electrical Phenomena at Interfaces and Biointerfaces

Fundamentals and Applications in Nano-, Bio-, and Environmental Sciences

By: Hiroyuki Ohshima

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Electrical Phenomena at Interfaces and Biointerfaces

Fundamentals and Applications in Nano-, Bio-, and Environmental Sciences

By: Hiroyuki Ohshima

This book bridges three different fields: nanoscience, bioscience, and environmental sciences. It starts with fundamental electrostatics at interfaces and includes a detailed description of fundamental theories dealing with electrical double layers around a charged particle, electrokinetics, and electrical double layer interaction between charged particles. The stated fundamentals are provided as the underpinnings of sections two, three, and four, which address electrokinetic phenomena that occur in nanoscience, bioscience, and environmental science. Applications in nanomaterials, fuel cells, electronic materials, biomaterials, stems cells, microbiology, water purificiaion, and humic substances are discussed.

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Page Count

870

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470582553

ISBN 13

9780470582558

Advances in Liquid Chromatography

35 Years of Column Liquid Chromatography in Japan

By: Toshihiko Hanai,Hiroyuki Hatano

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Advances in Liquid Chromatography

35 Years of Column Liquid Chromatography in Japan

By: Toshihiko Hanai,Hiroyuki Hatano

This book is a contemporary review of selected subjects in liquid chromatography, especially of the technical development, rather than the applications. The subjects are focused in the biomedical and environmental fields. This is also a troubleshooting record. Complex analytical problems such as sensitivity (sensitive detection by chemiluminescence, coulometric detection, laser based detection, necessity of degassing the system for sensitive detection), difficulty (free radical detection by Electron Spin Resonance, Polarimeter for chiral recognition) and reproducibility (packings for chiral separation and stable bonded silica gels) are solved. Theoretically and environmentally important miniaturizations are described. Individual chapters written by specialists provide information beyond what can be found in general textbooks of liquid chromatography.

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Page Count

366

Publisher

World Scientific

Published Date

ISBN 10

9810219067

ISBN 13

9789810219062

Design of Modern Highrise Reinforced Concrete Structures

By: Hiroyuki Aoyama

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Design of Modern Highrise Reinforced Concrete Structures

By: Hiroyuki Aoyama

This book presents the results of a Japanese national research project carried out in 1988-1993, usually referred to as the New RC Project. Developing advanced reinforced concrete building structures with high strength and high quality materials under its auspices, the project aimed at promoting construction of highrise reinforced concrete buildings in highly seismic areas such as Japan. The project covered all the aspects of reinforced concrete structures, namely materials, structural elements, structural design, construction, and feasibility studies. In addition to presenting these results, the book includes two chapters giving an elementary explanation of modern analytical techniques, i.e. finite element analysis and earthquake response analysis. Contents: RC Highrise Buildings in Seismic Areas (H Aoyama); The New RC Project (H Hiraishi); New RC Materials (M Abe & H Shiohara); New RC Structural Elements (T Kaminosono); Finite Element Analysis (H Noguchi); Structural Design Principles (M Teshigawara); Earthquake Response Analysis (T Kabeyasawa); Construction of New RC Structures (Y Masuda); Feasibility Studies and Example Buildings (H Fujitani). Readership: Civil, ocean and marine engineers.

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Page Count

462

Publisher

World Scientific

Published Date

ISBN 10

1848161670

ISBN 13

9781848161672

Statistical Inference

The Minimum Distance Approach

By: Ayanendranath Basu,Hiroyuki Shioya,Chanseok Park

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Statistical Inference

The Minimum Distance Approach

By: Ayanendranath Basu,Hiroyuki Shioya,Chanseok Park

In many ways, estimation by an appropriate minimum distance method is one of the most natural ideas in statistics. However, there are many different ways of constructing an appropriate distance between the data and the model: the scope of study referred to by "Minimum Distance Estimation" is literally huge. Filling a statistical resource gap, Stati

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Page Count

424

Publisher

CRC Press

Published Date

ISBN 10

1420099663

ISBN 13

9781420099669

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

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Page Count

119

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3319050265

ISBN 13

9783319050263

What Annually Laminated Sediments Reveal About the History of Environment and Civilization

By: Yoshinori Yasuda,Hiroyuki Kitagawa,Kazuyoshi Yamada,Mitsuru Okuno,Manabu Takahashi

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What Annually Laminated Sediments Reveal About the History of Environment and Civilization

By: Yoshinori Yasuda,Hiroyuki Kitagawa,Kazuyoshi Yamada,Mitsuru Okuno,Manabu Takahashi

This monograph presents a proposal for interdisciplinary and international research that uses varve as an essential tool. The discovery and subsequent palaeoenvironmental studies of the annually laminated sediments of Lake Suigetsu (Japan) revealed the directionality of a new discipline in the traditional field of historical science. The historical evidence of environmental changes and natural disasters provided by annually laminated sediments promote an integration of human and natural histories on a common time scale. To explore the impact of climatic changes and natural disasters on civilized society in the present and past, we simply open this door and enter a new phase in world history. The high resolution data about environmental history like climate, sea level, vegetation changes and natural disasters under the most reliable varve chronology will be discussed in relation to the development of human history and the rise and fall of civilizations. The book shows the direction of a new world history and new cosmology of the future civilization in relation to the environmental changes.

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Springer

Published Date

ISBN 10

4431550623

ISBN 13

9784431550624

Book's by Hiroyuki Kitagawa

The Unnormalized Relational Data Model

The Unnormalized Relational Data Model

Fracture Nanomechanics

Fracture Nanomechanics

Japanese Dentition: Anthropology And History

Japanese Dentition: Anthropology And History

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

Protein Targeting with Small Molecules

Protein Targeting with Small Molecules

Checking Theory and Grammatical Functions in Universal Grammar

Checking Theory and Grammatical Functions in Universal Grammar

Electrical Phenomena at Interfaces and Biointerfaces

Electrical Phenomena at Interfaces and Biointerfaces

Advances in Liquid Chromatography

Advances in Liquid Chromatography

Design of Modern Highrise Reinforced Concrete Structures

Design of Modern Highrise Reinforced Concrete Structures

Statistical Inference

Statistical Inference

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

What Annually Laminated Sediments Reveal About the History of Environment and Civilization

What Annually Laminated Sediments Reveal About the History of Environment and Civilization

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