Hiroyuki Inuzuka's Books

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

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Page Count

119

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3319050265

ISBN 13

9783319050263

Aho-Girl: A Clueless Girl

By: HIROYUKI

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Aho-Girl: A Clueless Girl

By: HIROYUKI

Stupid Is As Stupid Does -- Summer break has arrived, and with it come expanded opportunities for Yoshiko to practice self-expression. Of course, for someone as unburdened of intellect as she is, that self-expression tends to be rather lacking in sophistication. Okay, fine—it’s profoundly stupid. Her friend Akkun might be able to handle her, but will he be able to deal with Ryuichi the delinquent’s pathetic attempts at friendship? And what about Yoshiko’s mother’s increasingly manipulative attempts at setting Akkun up with her daughter? Oh, well. Surely a trip to the beach will sort everything out…

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Page Count

178

Publisher

Kodansha Comics

Published Date

ISBN 10

1682339513

ISBN 13

9781682339510

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

Write a review Read reviews Take a Quiz Solve Book Puzzle

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

119

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3319050265

ISBN 13

9783319050263

Book's by Hiroyuki Inuzuka

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

Aho-Girl: A Clueless Girl

Aho-Girl: A Clueless Girl

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

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