What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l
What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l
(Dulcimer). Music of the World for Mountain Dulcimer contains 38 beautiful songs from around the globe, all specially arranged for mountain dulcimer. This unique songbook features standard notation and tablature, song notes, a variety of tunings and styles, plus audio tracks with demonstrations of all the songs in the book.
Melanchthon and Calvin were late medieval people, stemming from a world of order and unity, and at the same time they fully lived in the early modern world, in which everything was changing. In this new world they committedly, enthusiastically, and restlessly sought to introduce some order, in theory as well as practice. The sixteenth-century church was governed by multiple coercive constructions and systems. Did the two Reformers really succeed in disconnecting themselves from them, and to what extent did they connect to, for example, the existing forms of eucharistic piety?The established church had come under serious criticism, and people were massively turning their backs on the less than attractive ecclesiastical practices—something connecting that era to ours. In these highly turbulent and suspenseful 1520s, when it was not yet clear whether the ten-year-old evangelical movement in Germany was still viable, Melanchthon tried to introduce at least some order into the chaos by means of a confession accompanied by a church order. As it turned out, the new doctrine on 'Christian freedom' and 'justification by faith alone' was easily interpreted in a one-sided manner. Through a careful analysis of the sources, Herman A. Speelman examines Melanchthon's church visitations in 1527 and Calvin's five attempts to shape the modernisation of ecclesiastical life. In addition to the gospel, also penance and the preaching of the law received a place in the Protestant liturgy and spirituality.Melanchthon's and Calvin's contributions were not only to have an enormous impact on the theological evolutions in the evangelical movement in Europe, but they also proved to be of eminent importance for the way in which the new doctrine was given meaning in practice. Their instructions continue to be highly influential in large parts of Europe today.
This text provides the most comprehensive, future-oriented overview of psychological theories and how they impact people decisions in today′s workplace with integrated coverage of technology, strategy, globalization, and social responsibility.
This richly illustrated book presents in detail the sanctuaries built during the reign of Antiochus I of Commagene (ca. 75-36 BCE), including the three large tombs and ten cult places, and discusses Antiochus’ rule in the context of his religious program and cult of the divine ruler. This book is the final publication of the results of the International Nemrud Daği Project 2001–2003.
This publication, "Viruses, Immunity and Immunodeficiency," is based on the first symposium in a series of International Biomedical Symposia sponsored by the College of Medicine of the University of South Florida in Tampa, Florida. There is an explosive interest concerning the effects of viruses on the immune response, especially the immunosuppressive effects of viral infection. This has come about because of the recognition that the Acquired Immunodeficiency Syndrome, which has taken biomedical scientists and the public in general by surprise, is just one of the many examples that viruses can influence the immune response system and, under appropriate circumstances, alter immunity in such a way that an infected individual becomes hi~lly susceptible to a variety of other organisms to which normal individuals would be resistant. This symposium series, sponsored by the University of South Florida College of Medicine, brings to the biomedical con®unity topics of current interest. We thank the members of the faculty of various departments of the College of Medicine and the administration of the College for their support and encouragement in having these symposiaat this medical school. This volume, based or. this symposium onviruses and immunity is a good exam ple of the interdisciplinary nature of modern irrJ!1I1nobiology and modern biomedical science in general. Many investigators with many different back grounds and training experiences, including microbiologists, immunologists, biochemists, oncologists, and physicians, are interested in how and why viruses influence the immune response system.
Figures of the Unconscious, No. 8Sigmund Freud, in his search for the origins of the sense of guilt in individual life and culture, regularly speaks of "reading a dark trace," thus referring to the Oedipus myth as a myth about the problem of human guilt. In Freud's view, this sense of guilt is a trace, a path, that leads deep into the individual's mental state, into childhood memories, and into the prehistory of culture and religion. Herman Westerink follows this trace and analyzes Freud's thought on the sense of guilt as a central issue in his work, from the earliest studies on the moral and "guilty" characters of the hysterics, via later complex differentiations within the concept of the sense of guilt, and finally to Freud's conception of civilization's discontents and Jewish sense of guilt. The sense of guilt is a key issue in Freudian psychoanalysis, not only in relation to other key concepts in psychoanalytic theory but also in relation to Freud's debates with other psychoanalysts, including Carl Jung and Melanie Klein.
Willem Marinus Dudok (1884-1974) is regarded internationally as one of the most important Dutch architects. As director of Public Works and City Architect to Hilversum, Dudok realized in that municipality not only his world-famous City Hall but also a welter of smaller projects including public baths, a library, housing, schools, a sports park and a cemetery. It was in this period that Dudok developed his own idiom, marked by compositions of cubic volumes. Besides his Hilversum buildings, others he built in Rotterdam, Paris and Velsen have been the subject of great interest. They are regarded as exemplifying an architecture that appeals not only to the professional world but also to the public at large. This compact though lavishly illustrated volume gives a complete overview of the major works by this architect who succeeded in striking a unique balance between modernism and tradition.
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