Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.
Pitcairn Island is arguably the most isolated inhabited spot on Earth. Yet despite tricky ocean currents, often lethal surf and sudden gales, the island's standing as the home of the descendants of Fletcher Christian and his mutineer cohorts from H.M.S. Bounty has drawn thousands of ships to its shores. This maritime history of the island chronicles every ship that has called at Pitcairn from the time of the arrival of the mutineers in 1790 to December 2010. The ship's log format lists the date of each call, the ship's name and particulars, and brief reports of activities during the call, which often include matters of love, murder, survival, intrigue, shipwreck, romance, and much more. Since Pitcairn remains totally dependent on ships for its survival, this work offers the most thorough historical record of the island and its people.
Margery Kempe's text draws on her maternal, female body to illuminate her relationship to the divine. A unique narrative of sin, sex and salvation, The Book of Margery Kempe comprises a text which has continued to perplex and fascinate contemporary audiences since its discovery in the library of an English country house in1934. Simultaneously exasperating, endearing, vulnerable and eccentric, Margery Kempe, mother of fourteen children and wife to a bemused John Kempe, provides us with an autobiographical account of her own singular brand of affective piety - excessive weeping, lack of bodily control, compulsive travelling, visionary meditations - and the growth of what she regarded as an individual and privileged mystical relationship with Christ. This new excerpted, thematically organised translation of the challenging text focuses on passages which will contextualise for the reader its author's reliance upon the experiences of her own maternal and sexualised body in an attempt to gain spiritual and literary authority. With detailed introduction and challenging interpretive essay, this volume uncovers in particular the importance of motherhood, sexuality and female orality to the inception and expression of Margery Kempe's singular mystical experiences and adds to contemporary debate regarding the agency of holy women during the later middle ages. LIZ HERBERT McAVOY is Lecturer in Medieval Language and Literature, University of Leicester.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.