Metabolic syndrome (MetS) is a clustering of metabolic complications representing a pre-morbid condition that is a substantial public health burden. Animal models provide an opportunity to examine correlations among different metabolic parameters to understand why metabolic complications sometimes cluster and sometimes do not. This chapter provides an overview of animal models of MetS that are used to understand etiology and pathophysiology, with a focus on methods of identifying and testing candidate genes with the aim of translating results to human studies. Genetic, epigenetic, environmental, and gene by environmental methods and results are discussed along with important lessons learned. Rodent models are the most frequently used, however other animal models including dogs, pigs, sheep, and non-human primates have contributed to our understanding of MetS and each are discussed. Additionally, animal models used to test physiological hypotheses are reviewed along with their potential to illuminate DNA sequence–metabolic function relationships to inform therapies.
Thrilling and illuminating."—LA Times "A hypnotic psychological thriller." —People A chance encounter sparks an unrelenting web of lies in this new gripping and complex psychological thriller from the New York Times bestselling author of The Good Girl and the upcoming page-turner Don't You Cry, Mary Kubica She sees the teenage girl on the train platform, standing in the pouring rain, clutching an infant in her arms. She boards a train and is whisked away. But she can't get the girl out of her head… Heidi Wood has always been a charitable woman: she works for a nonprofit, takes in stray cats. Still, her husband and daughter are horrified when Heidi returns home one day with a young woman named Willow and her four-month-old baby in tow. Disheveled and apparently homeless, this girl could be a criminal—or worse. But despite her family's objections, Heidi invites Willow and the baby to take refuge in their home. Heidi spends the next few days helping Willow get back on her feet, but as clues into Willow's past begin to surface, Heidi is forced to decide how far she's willing to go to help a stranger. What starts as an act of kindness quickly spirals into a story far more twisted than anyone could have anticipated. More Praise: "Hypnotic and anything but predictable." —Kirkus, starred review "A superb psychological thriller…stunning."—Publishers Weekly, starred review Read the New York Times bestselling novel that everyone is talking about, The Good Girl, by Mary Kubica! Look for Mary's latest complex and addictive tale of deceit and obsession, Don't You Cry. Order your copies today!
This book examines the relationship between imperial governance and political economy in eighteenth-century Britain, particularly in Canada and Ireland. It is concerned with the way economic ideology and party politics were mutually constitutive; and with the way extra-parliamentary interests both facilitated, and were co-opted into, strategies of governance and commercial regulation. Rather than treat political economy as a pre-existing intellectual orthodoxy that shaped imperial policymaking, it focuses on the ways in which economic thought was generated in moments of imperial crisis – especially those where politicians, commercial interest groups, and pamphleteer economists were forced to wrestle with the tensions between economic growth, political authority, and social stability. By rooting economic discourse and debate in specific problems of imperial commerce and administration, and by highlighting the many different actors and negotiations that produced economic policy, it argues that the transition from mercantilism to liberalism – the shift from protectionism to free trade – is a flawed description of eighteenth-century developments in economic thought.
The BRAND NEW gritty gangland thriller from Heather Atkinson!To survive, they’ll need to stick together... After the defeat of the rival Gordon and Thompson families, the Blood Brothers' reputations as feared lieutenants of the McVay clan are firmly established. The Gallowburn has become an untouchable stronghold in their capable hands. However, danger rears its head in another form - Jamie’s deadliest foe, Cameron Abernethy. Still fighting to be released from prison, Cameron decides to use the Lawson family, the Blood Brothers’ biggest rivals, to discover his daughter's whereabouts. With his enemies getting closer, and the police on his tail too, Jamie has some impossible choices to make. This is his last chance to live the life he's dreamed of with the woman he loves, but first he’s got to make sure he's not caught or killed... If you love Kimberley Chambers, and Jessie Keane, you’ll love Blood Pact. Discover the bestselling gangland author Heather Atkinson and you'll never look back... What readers are saying about Heather Atkinson: 'Another brilliant book from Heather...she really is one the best in the business. ' 'I have read ALL Heather Atkinson's books. They are all fantastic.' 'All Heather's books are action packed and have you on edge.' 'I stumbled upon Heather's books and I'm so glad I did, characters excellent and storylines are great , I find myself searching the book stores for more of them to read the minute I finish one.
Many homeowners look at decorating as a do-it-yourself proposition. Others seek out the advice of an expert. Bursting with more than 500 photographs and drawings, this sourcebook contains all the ideas a potential decorator needs to transform his house into a showcase.
Brimming with visual inspiration for every room in the house--and outdoor areas too--this book is packed with hundreds of full-color photos that inspire readers with ways to solve problems and improve their homes.
Discover the gripping Gallowburn series from bestselling author Heather Atkinson Martina Cole, Kimberley Chambers, and Jessie Keane This boxset contains the complete Gallowburns series Blood Brothers Bad Blood Blood Ties Blood Pact Blood Brothers Gangs rule the streets of the rough Gallowburn Estate in Glasgow, but the deepest rivalry of all is between Jamie Gray and his friends, known as the Blood Brothers, and their enemies, the Lawsons. The two gangs clash frequently, but when a phone containing incriminating evidence disappears after a particularly brutal run-in, the stakes are higher than ever. Bad Blood Glasgow gangster Jamie Gray and his fellow Blood Brothers rule the Gallowburn Estate with an iron fist. No one messes around on their turf without consequences. But when Jamie’s erstwhile dad, Jason Gray, reappears after many years away - some of them spent behind bars - the Blood Brothers are drawn into the murky and dangerous world of the toughest gangster of them all – The Queen of Glasgow, Toni McVay. Blood Ties The Queen of Glasgow, Toni McVay, is no ordinary crime boss. For one thing, she likes to discipline disappointing employees by scooping out their eyeballs and keeping them as souvenirs. Jamie Gray and his gang the Blood Brothers are happy to do her dirty work in return for lessons in the ways of the local underworld, but are in no doubt that they need to keep Toni sweet to keep themselves safe. Rival families The Gordons and The Thompsons are ready for a turf war, keen to take over the lucrative Gallowburn estate, and weaken Toni’s grip on the city. But can the old enemies really trust each other enough to join forces? And will their assumption that the Blood Brothers are the weak link in the McVay empire, prove to be their greatest mistake? Blood Pact The Blood Brothers' reputations as feared lieutenants of the McVay clan are firmly established. The Gallowburn has become an untouchable stronghold in their capable hands, but strongholds invite attacks. With his enemies getting closer, and the police on his tail too, Jamie has some impossible choices to make. This is his last chance to live the life he's dreamed of with the woman he loves, but first he’s got to make sure he's not caught or killed...
When you’re running the streets, loyalty is everything... Gangs rule the streets of the rough Gallowburn Estate in Glasgow, but the deepest rivalry of all is between Jamie Gray and his friends, known as the Blood Brothers, and their enemies, the Lawsons. The two gangs clash frequently, but when a phone containing incriminating evidence disappears after a particularly brutal run-in, the stakes are higher than ever. Jamie’s mother Jackie is as hard as nails and is not going to let anyone hurt her boy – even if she has to roll up her sleeves and get stuck in. What she wants more than anything though, is to see Jamie turn his back on the street life. And when he meets spoilt rich-girl Allegra, who has a penchant for shoplifting, Jackie thinks she could be Jamie’s way out. But with the Lawsons closing in, and everyone taking sides, there is only one way out for Jamie, and to triumph he must take out his biggest enemy... If you love Martina Cole, Kimberley Chambers, and Jessie Keane, you’ll love Heather Atkinson. Discover the bestselling author Heather Atkinson, her crackling plots, unforgettable characters and page-turning pace and you'll never look back... What readers are saying about Heather Atkinson: 'Another brilliant book from Heather...she really is one the best in the business. ' 'I have read ALL Heather Atkinson's books. They are all fantastic.' 'All Heather's books are action packed and have you on edge.' 'I stumbled upon Heather's books and I'm so glad I did , characters excellent and storylines are great , I find myself searching the book stores for more of them to read the minute I finish one.
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