Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma. Key Features * Presents the recent progress made in the research on the blood-brain and spinal cord barrier * Contains numerous illustrations of light and electron micrographs * Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro
This book addresses the mapping of soil-landscape parameters in the geospatial domain. It begins by discussing the fundamental concepts, and then explains how machine learning and geomatics can be applied for more efficient mapping and to improve our understanding and management of ‘soil’. The judicious utilization of a piece of land is one of the biggest and most important current challenges, especially in light of the rapid global urbanization, which requires continuous monitoring of resource consumption. The book provides a clear overview of how machine learning can be used to analyze remote sensing data to monitor the key parameters, below, at, and above the surface. It not only offers insights into the approaches, but also allows readers to learn about the challenges and issues associated with the digital mapping of these parameters and to gain a better understanding of the selection of data to represent soil-landscape relationships as well as the complex and interconnected links between soil-landscape parameters under a range of soil and climatic conditions. Lastly, the book sheds light on using the network of satellite-based Earth observations to provide solutions toward smart farming and smart land management.
This is a concise, systematic and complete treatment of the design and construction of pile foundations. Discusses pile behavior under various loadings and types of piles and their installation, including consideration of soil parameters. It provides step-by-step design procedures for piles subject to vertical loading and pullout, lateral, inclined and eccentric loads, or dynamic loads, and for piles in permafrost. Also describes load test procedures and their interpretation and buckling of long, slender piles with and without supported length. The closing chapter presents case histories of prediction and performance of piles and pile groups. Includes numerous solved problems.
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