This book analyzes the social capital of the growing knowledge economy, from both theoretical and empirical points of view. The theoretical section discusses social capital as an economic concept, developing a theory of the social capital of the enterprise. The empirical section compares aspects of the social capital of three different socio-economic systems: the US, Japan and Sweden. The book discusses a number of issues for further research.
In the emerging new collaborative economic order, innovation is achieved by an integrated process of collaboration between policymakers, business and society. Often, the focus for this collaboration is at a regional level. Creating Collaborative Advantage examines the trends in innovation policy that reflect this new thinking and regional focus. This book develops the view that collaboration is one of many ways of organising a competitive economy. It asks how, when and where collaboration is a meaningful way of organisation. It explores collaboration at business level, business networks between companies, and a wider collaborative coalition between business and public authorities. It is not a manual, a 'how to do it', because there is no single straightforward universal model to replace current orthodoxy on economic development, but it will enable people to learn. The contributors to this unique book have been involved with the implementation of some of the most outstanding examples of collaborative approaches, it therefore gives an outstanding picture of diversity, inbuilt comparisons and contrast, and debate between the cases. The co-authors give their understanding of these issues, but the book tries to establish some common understandings and bring the concept of collaboration to a larger audience, and to increase interest in a field which requires further exploration. Policy makers, advisers and administrators at all levels of government, those involved in research and development, and business leaders and educators, will find this book invaluable, together with readers having an academic interest in the subject of innovation.
Connections define the functions of neurons: information flows along connections, as well as growth factors and viruses, and even neuronal death can progress through connections. Accordingly, knowing how the various parts of the brain are interconnected to form functional systems is a prerequisite for properly understanding data from all fields in the neurosciences. Clinical Neuroanatomy: Brain Circuitry and Its Disorders bridges the gap between neuroanatomy and clinical neurology. It focuses on human and primate data in the context of brain circuitry disorders, which are so common in neurological practice. In addition, numerous clinical cases are presented to demonstrate how normal brain circuitry can be interrupted, and what the effects are. Following an introduction to the organization and vascularization of the human brain and the techniques used to study brain circuitry, the main neurofunctional systems are discussed, including the somatosensory, auditory, visual, motor, autonomic and limbic systems, the cerebral cortex and complex cerebral functions. In this 2nd edition, apart from a general updating, many new illustrations have been added and more emphasis is placed on modern techniques such as diffusion magnetic resonance imaging (dMRI) and network analysis. Moreover, a developmental ontology based on the prosomeric model is applied, resulting in a more modern subdivision of the brain. The new edition of Clinical Neuroanatomy is primarily intended for neurologists, neuroradiologists and neuropathologists, as well as residents in these fields, but will also appeal to (neuro)anatomists and all those whose work involves human brain mapping.
Entrepreneurial Imagination innovatively focuses on entrepreneurial and economic action in time, timing, space and place. Schedules and places of production, working times and working places, are no longer fixed due to the effects of the contemporary economy. The authors expertly bring together a focused and themed book that deals wholly with the subjects of time and space in a phenomenological understanding of entrepreneurial ventures and related business action. They discuss theories and thinking of human action, space, place, timing and time in various entrepreneurial and business arenas, including social entrepreneuring, environmental and corporate social responsibility, network forms of entrepreneuring, urban governance and regional development. Taking a phenomenological approach to enable readers to understand entrepreneurship and related economic action clearly will prove to be inspiring for students, academics and practitioners interested in all areas of entrepreneurship and similar issues.
This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These chapters are abundantly illustrated in colour with carefully chosen clinical case studies with imaging data, and when available, postmortem verification of the developmental disorders involved. In the third edition, more emphasis has been given to the developmental ontology based on the prosomeric approach, and fetal development. Prenatal diagnosis by ultrasound, MRI and DTI, and classifications of developmental disorders have been updated. A number of new Clinical Cases have been included. Several new co-authors participate in various chapters. The book is intended for advanced medical students, and all those clinicians working with children and adults with developmental disorders of the CNS. Unique to the book is the integration of data from human embryology, experimental and molecular findings in mice in particular, imaging and developmental neuropathology.
An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.
This book contributes to re cent developments on the statistical analysis of multiple time series in the presence of regime shifts. Markov-switching models have become popular for modelling non-linearities and regime shifts, mainly, in univariate eco nomic time series. This study is intended to provide a systematic and operational ap proach to the econometric modelling of dynamic systems subject to shifts in regime, based on the Markov-switching vector autoregressive model. The study presents a comprehensive analysis of the theoretical properties of Markov-switching vector autoregressive processes and the related statistical methods. The statistical concepts are illustrated with applications to empirical business cyde research. This monograph is a revised version of my dissertation which has been accepted by the Economics Department of the Humboldt-University of Berlin in 1996. It con sists mainly of unpublished material which has been presented during the last years at conferences and in seminars. The major parts of this study were written while I was supported by the Deutsche Forschungsgemeinschajt (DFG), Berliner Graduier tenkolleg Angewandte Mikroökonomik and Sondeiforschungsbereich 373 at the Free University and Humboldt-University of Berlin. Work was finally completed in the project The Econometrics of Macroeconomic Forecasting founded by the Economic and Social Research Council (ESRC) at the Institute of Economies and Statistics, University of Oxford. It is a pleasure to record my thanks to these institutions for their support of my research embodied in this study.
The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry itself. Depending on the maturity of the technology, the chapters address in turn the expression system, basic process design, key factors affecting process economics, plant and bioreactor design, and regulatory aspects.
Over the past 50 years, scientists have made incredible progress in the application of genetic research to human health care and disease treatment. Innovative tools and techniques, including gene therapy and CRISPR-Cas9 editing, can treat inherited disorders that were previously untreatable, or prevent them from happening in the first place. You can take a DNA test to learn where your ancestors are from. Police officers can use genetic evidence to identify criminals—or innocents. And some doctors are using new medical techniques for unprecedented procedures. Genomics: A Revolution in Health and Disease Discovery delves into the history, science, and ethics behind recent breakthroughs in genetic research. Authors Whitney Stewart and Hans Andersson, MD, present fascinating case studies that show how real people have benefitted from genetic research. Though the genome remains full of mysteries, researchers and doctors are working hard to uncover its secrets and find the best ways to treat patients and cure diseases. The discoveries to come will inform how we target disease treatment, how we understand our health, and how we define our very identities.
Usually, the first edition of a book still contains a multiplicity of typographic, con ceptional, and computational errors even if one believes the opposite at the time of publication. As this book did not represent a counterexample to this rule, the current second edition offers a chance to remove at least the known shortcomings. The book has been partly re-organized. The previously rather long Chapter 4 has been split into two separate chapters dealing with discrete-time and continuous time approaches to nonlinear economic dynamics. The short summary of basic properties of linear dynamical systems has been banned to an appendix because the line of thought in the chapter seems to have been unnecessarily interrupted by these technical details and because the book concentrates on nonlinear systems. This appendix, which mainly deals with special formal properties of dynamical sys tems, also contains some new material on invariant subspaces and center-manifold reductions. A brief introduction into the theory of lags and operators is followed by a few remarks on the relation between the 'true' properties of dynamical systems and their behavior observable in numerical experiments. Additional changes in the main part of the book include a re-consideration of Popper's determinism vs. inde terminism discussion in the light of chaotic properties of deterministic, nonlinear systems in Chapter 1. An investigation of a simultaneous price-quantity adjustment process, a more detailed inquiry into the uniqueness property of limit cycles, and a short presentation of relaxation oscillations are included in Chapter 2.
The serial optical data format has attracted attention for decades now, because of its promise to reduce the number of active components in a communication system. Indeed, historically increasing the serial bit rate by a factor of 4, reduced the cost per bit by 40%. Going beyond the available electronic bandwidth (roughly 100GHz today) can be obtained using optical time division multiplexing (OTDM), and symbol rates up to 1.28Tbaud per polarization have been demonstrated. As most optical signal processing devices operate on a per channel basis, it is advantageous to aggregate the data in a serial format, since this allows for optical signal processing of many bits in a single device. This chapter gives an overview of the state-of-the-art of OTDM systems to reach multi-Tbit/s serial data and means to handle these ultra-high bit rate signals using for instance nonlinear silicon waveguides for e.g. serial-to-parallel conversion.
This book is unique in that it provides the reader with the most up-to-date terminology used to describe the human nervous system (central and peripheral) and the related sensory organs, i.e., the Terminologia Neuroanatomica (TNA), the official terminology of the IFAA (International Federation of Associations of Anatomists). The book provides a succinct but detailed review of the neuroanatomical structures of the human body and will greatly benefit not only various specialists such as (neuro)anatomists, neurologists and neuroscientists, but also students taking neuroanatomy and neuroscience courses. The book offers a high yield, combined presentation of neuroanatomical illustrations and text and provides the reader a ‘one-stop source’ for studying the intricacies of the human nervous system and its sensory organs. It includes an alphabetical list of official English terms and synonyms with the official Latin terms and synonyms from the TNA. With regard to the entries, the name of the item in standardized English is provided, followed by synonyms and the official TNA Latin term, Latin synonyms and eponyms, a short description and in many cases one or more illustrations. To facilitate the use of illustrations, certain entries such as the gyri or sulci of the cerebral cortex are presented together with extensive cross-references. Terms that form part of a certain structure (such as the amygdaloid body, the thalamus and the hypothalamus) are listed under the respective structure. Segments and branches of arteries are discussed under the main artery, for example the A1–A5 segments under the anterior cerebral artery. Most nerves can be found following their origin from the brachial, cervical and lumbosacral plexuses. However, the major nerves of the limbs are discussed separately, as are the cranial nerves. Nuclei can be found by their English name or under Nuclei by their eponym.
Joining insights from social science and philosophy, this book offers a nuanced view on the discourse of evil, which has been on the rise in the West in recent years. Exploring the famous ‘Pear Theft’ episode in St Augustine’s Confessions, it looks beyond the theological implications of the event to focus instead on the secular insights that it offers when the event is placed in the context of social thought. With attention to Augustine’s lengthy reflections on a seemingly marginal episode, the author contends that it is possible to discern the elements of a convincing account of intentional evil action, the Pear Theft representing a case of joint radical improvisation that lacks collective deliberation. As such, a new perspective emerges on familiar and more intuitive forms of evil in joint action that involve group identification and institutional action. Evil in Joint Action will appeal to scholars of sociology, social theory and philosophy with interests in ethics, collective action and concepts of evil.
This comprehensive reference is clearly destined to become the definitive anatomical basis for all molecular neuroscience research. The three volumes provide a complete overview and comparison of the structural organisation of all vertebrate groups, ranging from amphioxus and lamprey through fishes, amphibians and birds to mammals. This thus allows a systematic treatment of the concepts and methodology found in modern comparative neuroscience. Neuroscientists, comparative morphologists and anatomists will all benefit from: * 1,200 detailed and standardised neuroanatomical drawings * the illustrations were painstakingly hand-drawn by a team of graphic designers, specially commissioned by the authors, over a period of 25 years * functional correlations of vertebrate brains * concepts and methodology of modern comparative neuroscience * five full-colour posters giving an overview of the central nervous system of the vertebrates, ideal for mounting and display This monumental work is, and will remain, unique; the only source of such brilliant illustrations at both the macroscopic and microscopic levels.
This book analyzes the social capital of the growing knowledge economy, from both theoretical and empirical points of view. The theoretical section discusses social capital as an economic concept, developing a theory of the social capital of the enterprise. The empirical section compares aspects of the social capital of three different socio-economic systems: the US, Japan and Sweden. The book discusses a number of issues for further research.
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