First published in 1989, written with contributions from experts who have critically evaluated the state of the art and the prospects of isolated adults cardiac myocytes in cardiological research, this two-volume publication summarizes the current knowledge of this technology. The methodology, structure, and metabolism of cardiomyocytes are presented, along with metabolism and cation homeostasis and energy metabolism and hypoxic injury. Additionally, cell isolation and culture and the structure and biochemistry of the sarcolemma is explained. Electrophysiology and contractile function with ionic currents and membrane channels is discussed. Also, the electro-physiological effects of transmitters and hormones are presented, with excitation-contraction coupling and the use of cardiomyocytes in drug design and research explained.
Erstmals wird hier die Fulle der englischsprachigen Athiopienliteratur geordnet dargeboten. In 100 Sections fuhrt der Autor alle fur die wissenschaftliche Beschaftigung mit Athiopien wichtigen Buch- und Zeitschriftenbeitrage zum Beispiel zur "Historyof Research", "Archaeology", "Religion", aber auch Fragen der "Sociology", "Agriculture", "Zoology" und "Medical Sciences" auf. Wie im Falle der deutschsprachigen Literatur ("Bibliographia Aethiopica: Die athiopienkundliche Literatur des deutschsprachigenRaumes" = Aethiopistische Forschungen 9 [1982]) berucksichtigt der Autor auch alle ihm zuganglichen Besprechungen, womit bei einer Aufnahme von mehr als 24.000 Titeln eine Art "Bibliographic Enzyclopedia" entstanden ist.
This book provides the tools to maintain and rebuild the interaction between architecture and public space. Despite the best intentions of designers and planners, interactive frontages have dwindled over the past century in Europe and North America. This book demonstrates why even our best intentions for interactive frontages are currently unable to turn a swelling tide of economic and technological evolution, land consolidation, introversion, stratification, and contagious decline. It uses these lessons to offer concrete locational, programming, design, and management strategies to maximize street-level interaction and trust between street-level architecture, its inhabitants, and the city. This book demonstrates that designers, developers, planners, and managers ultimately have to create the right preconditions for inhabitants and passersby to bring frontages to life. These preconditions connect architecture to its urban, social, economical, and technological context. Only the right frontage in the right context, with the right design, the right inhabitation, and the right attitude to the city will become part of the ecosystem of trust and interaction that supports public life. This book empowers the many participants in this ecosystem to build, inhabit, and enjoy truly urbane architecture.
Traditional text types (or genres) are complex linguistic, sociocultural and cognitive phenomena that can only be analysed in flexible interdisciplinary frameworks fusing structural and process-oriented approaches and combining quantitative description with qualitative interpretation and evaluation.The theoretical and methodological implications of the prototypical text type concept which is developed in this book are explored in an exhaustive case study of a representative (ie prototypical) genre: the wedding report, a conventional type of news report published in local English newspapers. The distinctive contextual and textual features situational context, text production processes, function, thematic structure, and form on the macro- and microlevel are analysed synchronically and diachronically. The linguistic findings are integrated into a comprehensive view of the interplay between the genre as a linguistic frame and its sociocultural context.The study puts special emphasis on addressing the methodological problems arising from the inherent fuzziness of traditional text types, and can thus serve as a detailed working model of genre analysis, designed to be adapted to the specific requirements of similar studies.
The volume continues the description of acyclic sulfur - nitrogen compounds with sulfur having the oxidation number II and covers amino-di- and aminopolysulfanes as well as diamino-di- and diamino-polysulfanes. Numerous examples of the class of diamino-disulfanes and their interesting chemical properties are described: N, N'-disulfanediyl-bis(N-heterocycles), for instance, undergo S-S bond scission in a thermal or photochemical radical - dimer equilibrium or react with acetylenes to give thiophenes, and N, N'disulfanediyl-bis(phthalimide) is a sulfur transfer reagent for organic synthesis. The volume completes the series on sulfur - nitrogen compounds which is a unique and comprehensive source of information for this field in chemistry.
“Jesus Christ” denied that there is a “Last Judgement,” “heaven” or “hell” (to come), (see: Lu 17:20-21). “Religion,” “truths” and “love” etc. are that what one makes others believe according to the credo (of megalomania) a) faith shifts mountains (see: Mt 17:20) and the truths anyway and b) “do not resist the evil” (Mt 5:39). Since the sinners, cannot comply with the notions of god, truths, ethics, love, and religion, they shall adapt those terms corresponding to their depravities. Hence, the only thing that came and always is going to occur is the Christians’ criminal record but no heaven.
Jesus is a cripple (blind in one eye, limping and dwarfish). He did not die on the cross, but gulled Judas Iscariot into dying on the cross in place of him. He laughed up his sleeve at the crucified one. The “official” part of Judas Iscariot as the purported “betrayer” escorting the troops to the delinquent also was screened by another double: Simon of Cyrene. At least two times more he escaped from the death penalty by a stuntman.
The conversion of Lutz Löb and Jenny van Gelder from Judaism to Roman Catholicism dramatically changed the lives of the extended Löb family. This scientific-historical study traces the personal and spiritual journey of Lutz and Jenny from their baptisms in 1907 through the lives of their children. The story benefits from historical documents and pieces of oral history from the only one of their eight children who survived the Nazi era, Paula van Broekhoven-Löb. The abbess of Koningsoord Abbey and the abbot of Koningshoeven Abbey generously provided access to the archives of the monasteries where the seven other Löb children lived as nuns and monks of the Löb family. Each chapter begins with a citation from a significant situation or event, placing the reader immediately within the lived experience of that period. Photos of the time and the family supplement the historical narrative. The secret conversion of Lutz and Jenny and their lifelong witness to their faith created a tear in the fabric of the extended family while later leading to many idealized portrayals of them and their children. It is the intent of this book to offer an accurate and balanced account, situating the Catholic Löb family within their extended Jewish family, and to correct several decades of hagiography, so restoring humanity and dignity to the memories of the Löb family.
This book is an introduction for students and young doctors at thebeginning of their career in diagnostic ultrasonography. It alsopresents the latest in innovations and techniques in gastrointestinalultrasonography. The reader will find basic aspects of ultrasonographyas well as highly advanced technical and research papers.
This is a uniquely well-informed and comprehensive guide to the world of religion in the Graeco-Roman environment of early Christianity. Drawing on the most up-to-date scholarship, the volume paints a carefully nuanced portrait of the Christians' religious context. Besides describing ordinary domestic and civic religion and popular belief (including astrology, divination and 'magic'), there is extended discussion of mystery cults, ruler and emperor cults, the religious dimensions of philosophy, and Gnosticism. A valuable textbook for advanced students, as well as an authoritative reference work for scholars.
The objective of this book is to provide future entrepreneurs in start-up companies, medium-sized enterprises, and corporations with knowledge and a set of tools they can immediately use to develop their entrepreneurial mindset. The book has a clear focus on the needs of engineers; it covers business cases, experiences from entrepreneurs, and examples from industry to optimize the learning benefit.
After considering the aging population in developed countries, it has become clear to physicians and public policy administrators that prevention of cancer must play a more important role in national anti-cancer policy than it has in the past. The recent introduction of an HPV vaccine, coupled with discoveries concerning the relationship of H. pylori and cancer has brought the role of infectious agents in cancer into sharp focus in the medical community. While interest in the subject has grown, no single source existed to bring clinicians up-to-date on developments in disease mechanisms, population-based risk assessment and policy considerations in the field of cancer prevention. In this current and comprehensive text the authors review the basic science and clinical implications of individual infectious agents, while going beyond a mere update of the literature to offer insights on the current emerging prevention possibilities. This prevention perspective is what makes this particular text so valuable to researchers, epidemiologists, health care policy makers and oncologists. The discussion is organized to highlight the vital role of primary cancer prevention, and suggest directions for future research, practice and policy. Since HPV continues to be at the center of interest in the arena of infectious agents and cancer, the authors frame the majority of their discussion on this now-famous virus. The sheer volume of literature related to this virus and its many related cancers, and the burgeoning research on the development and implementation of a prophylactic vaccine necessitates a much fuller review of this infectious agent. Therefore, the book is roughly divided into two equal parts: one part devoted to HPV and another part devoted to five other prominent infectious agents in cancer.
Engrossing journey through the workings of the universe and minds of today’s scientific thinkers examines an extraordinary range of topics—from the Superconducting Super Collider and the mysteries of the Big Bang, to strange crystals with impossible structures and the quest for the temperature of absolute zero. A richly satisfying work teeming with the drama of scientific research and the thrill of discovery will appeal to scientists and laypeople alike.
PF3, (CH3)3SiCl -> (CH3)3SiF, and RC(O)Cl -> RC(O)F. Others include the conversion of (C6H5)3P into (C6H5)3PF2 and of (R3NC(S)S)2 into R2NCF3, R=alkyl. In organic chemistry, fluorides are easily accessible from alcohols, geminal fluorides RR'CF2 from the respective aldehydes or ketones, and acyl fluorides RC(O)F from carboxylic acides by using DAST. Because DAST is easy to handle and gives clean reactions in syntheses, this Gmelin volume devotes much space to the description of the chemical and physical properties od DAST.
The Weimar period in Germany was a time of radical change, when the traditions and social hierarchies of Imperial Germany crumbled, and a young, deeply conflicted republic emerged. Modernity brought changes that reached deep into the most personal aspects of life, including a loosening of gender roles that opened up new freedoms and opportunities to women. The screen vamps, garçonnes, and New Women in this movie-hungry society came to embody the new image of womanhood: sexually liberated, independent, and—at least to some—deeply threatening. In Gender and the Uncanny in Films of the Weimar Republic, author Anjeana K. Hans examines largely forgotten films of Weimar cinema through the lens of their historical moment, contemporary concerns and critiques, and modern film theory to give a nuanced understanding of their significance and their complex interplay between gender, subjectivity, and cinema. Hans focuses on so-called uncanny films, in which terror lies just under the surface and the emancipated female body becomes the embodiment of a threat repressed. In six chapters she provides a detailed analysis of each film and traces how filmmakers simultaneously celebrate and punish the transgressive women that populate them. Films discussed include The Eyes of the Mummy (Die Augen der Mumie Mâ, Ernst Lubitsch, 1918), Uncanny Tales (Unheimliche Geschichten, Richard Oswald, 1919), Warning Shadows (Schatten: Eine nächtliche Halluzination, Artur Robison, 1923), The Hands of Orlac (Orlacs Hände, Robert Wiene, 1924), A Daughter of Destiny (Alraune, Henrik Galeen,1928), and Daughter of Evil (Alraune, Richard Oswald, 1930). An introduction contextualizes Weimar cinema within its unique and volatile social setting. Hans demonstrates that Weimar Germany’s conflicting emotions, hopes, and fears played out in that most modern of media, the cinema. Scholars of film and German history will appreciate the intriguing study of Gender and the Uncanny in Films of the Weimar Republic.
This mini-encyclopedia contains more than 1,500 alphabetical entries from the entire field of peptide science in one handy volume, as well as the technical terms, acronyms and concepts used in peptide chemistry. It also features the complete sequence of more than 800 peptides, numerous illustrations and numerous cross-references. Areas covered include: - biological peptides and small proteins - peptide hormones - pharmaceutical peptides - peptide antibiotics - peptide inhibitors - peptide reagents - peptide tags - structural classes - synthesis and purification - analytical methods - proteomics and peptidomics. Condensed yet accessible, only essential information is displayed, extensively linked via references to the recent scientific literature for further study.
Strategic thinking rather than strategic planning is the key to sustainable success. Strategy involves a broader look, a deeper analysis and a longer time-frame. Strategic thinking is about considering the consequences of developments and possible developments, of actions and possible actions, on the success, prosperity and continuity of people, organizations or communities. And it is about the kind of success, prosperity and continuity that we seek. This study explores strategic thinking on the basis of strategy literature and cognitive psychology. It reviews studies of how strategic decision-makers operate, including the military. It helps to recognize strategic thinking ability in individuals, to teach strategic thinking and to foster it in those at the helm: directors, executives, commanders and public administrators.
In its fully revised and updated second edition, Musculoskeletal Imaging covers every aspect of musculoskeletal radiology. This medical reference book incorporates the latest diagnostic modalities and interventional techniques, as well as must-read topics such as hip, groin and cartilage imaging; newly described impingements; and new concepts in the hip including teres ligament pathology. This publication is a key title in the popular Expert Radiology Series, which delivers evidence-based expert guidance from around the globe. Fully understand each topic with a format that delivers essential background information. Streamline the decision-making process with integrated protocols, classic signs, and ACR guidelines, as well as a design that structures every chapter consistently to include pathophysiology, imaging techniques, imaging findings, differential diagnosis, and treatment options. Write the most comprehensive reports possible with help from boxes highlighting what the referring physician needs to know, as well as suggestions for treatment and future imaging studies. Access in-depth case studies, valuable appendices, and additional chapters covering all of the most important musculoskeletal procedures performed today. Quickly locate important information with a full-color design that includes color-coded tables and bulleted lists highlighting key concepts, as well as color artwork that lets you easily find critical anatomic views of diseases and injuries. Engage with more than 40 brand-new videos, including arthroscopic videos. Easily comprehend complicated topics with over 5,000 images and new animations. Explore integrated clinical perspectives on the newest modalities such as PET-CT in cancer, diffusion MR, as well as ultrasonography, fusion imaging, multi-slice CT and nuclear medicine. Learn from team of international experts provides a variety of evidence-based guidance, including the pros and cons of each modality, to help you overcome difficult challenges. Consult this title on your favorite e-reader.
Pathology and Pathobiology of Rheumatic Diseases glows with the uncommon precision of the pathologist, the clarity of the tea cher, and the unswerving commitment of the investigator. Fass bender has produced a major contribution to the literature of rheumatic diseases. The practical experience and wisdom brought together in this book, substantiated by excellent exam ples of histopathology, produce a landmark for all who have made the study of rheumatic diseases their profession. The enor mous achievements made in molecular biology, genetics, struc tural biochemistry, and clinical science have been assembled in this book to interact in a meaningful way with the anatomical histology of the rheumatic diseases. It is not easy for any single investigator to paint the picture of a disease process, from its clinical description to its mechanisms, and then to a defined hypothesis, and finally an understanding. Nonetheless, Fassbender has done this in a clear and convincing way that integrates our current knowledge of this group of dis eases. Scientific discovery in medicine moves from the bedside to the bench, back to the bedside, and then back to the bench, etc. It is this iterative process of new observation and new discovery that has given us the achievements in medicine over the past century.
In September, 1976, the International Federation for Cell Biology held its first congress in Boston. On this occasion Berlin was chosen as the site for the next congress. This meant an acknowledgement and at the same time a heavy burden for the still young European Cell Biology Organization, which repre sents a junction of European societies and groups for cell biology. In practical terms, this meant that the members of the young and, compared to the Ame rican Society for Cell Biology, small German Society for Cell Biology had to do a good deal of the organizing of the Cell Biology Congress. This is an op portunity for me, as Chairman of the Organizing Committee, and also on be half of the German Society for Cell Biology, to express my gratitude to all those who have actively participated in the preparations for this Cell Biology Congress. The success of the Congress in Berlin was to a significant extent due to their work. In particular, I would like to especially thank the Secretary General ofECBO Werner Franke, Heidelberg, as well as the Chairman of the Local Organizing Committee, Peter Giesbrecht, Berlin, for the excellent job they did. The Congress in Berlin proved to be significantly larger than that in Boston in 1976. The number of abstracts increased from 1200 to more than 1800. They have been published in the European Journal of Cell Biology. In a simi lar way the number of symposia and workshops expanded.
This unique dictionary covers all the major German idioms and is probably the richest source of contemporary German idioms available, with 33,000 headwords. Within each entry the user is provided with: English equivalents; variants; contexts and precise guidance on the degree of currency/rarity of an idiomatic expression. This dictionary is an essential reference for achieving fluency in the language. It will be invaluable for all serious learners and users of German. Not for sale in Germany, Austria and Switzerland.
In this book Hans-Josef Klauck provides a comprehensive introduction to the apocryphal gospels - the biblical and related writings which do not form part of the accepted canon of Scripture.Klauck classifies the material in various helpful ways: Agrapha (isolated sayings if Jesus), Fragments, Jewish Christian Gospels, Two Gospels of the Egyptians, Infancy Gospels, Gospels about Jesus' Death and Resurrection, Gospels from Nag Hammadi, Conversations with the Risen Jesus, Dialogues of Jesus with No Location, Legends about the Death of Mary, Lost Gospels, the Toledot Jeshu (an anti-gospel) . Each section is accompanied by a carefully related bibliography. This highly readable introduction takes account of all the latest international scholarship on the apocrypha and will be an invaluable resource for all scholars and students in the field.
This study discusses the history of the central limit theorem and related probabilistic limit theorems from about 1810 through 1950. In this context the book also describes the historical development of analytical probability theory and its tools, such as characteristic functions or moments. The central limit theorem was originally deduced by Laplace as a statement about approximations for the distributions of sums of independent random variables within the framework of classical probability, which focused upon specific problems and applications. Making this theorem an autonomous mathematical object was very important for the development of modern probability theory.
The general theory of relativity is a theory of manifolds equipped with Lorentz metrics and fields which describe the matter content. Einstein's equations equate the Einstein tensor (a curvature quantity associated with the Lorentz metric) with the stress energy tensor (an object constructed using the matter fields). In addition, there are equations describing the evolution of the matter. Using symmetry as a guiding principle, one is naturally led to the Schwarzschild and Friedmann-Lemaitre-Robertson-Walker solutions, modelling an isolated system and the entire universe respectively. In a different approach, formulating Einstein's equations as an initial value problem allows a closer study of their solutions. This book first provides a definition of the concept of initial data and a proof of the correspondence between initial data and development. It turns out that some initial data allow non-isometric maximal developments, complicating the uniqueness issue. The second half of the book is concerned with this and related problems, such as strong cosmic censorship. The book presents complete proofs of several classical results that play a central role in mathematical relativity but are not easily accessible to those without prior background in the subject. Prerequisites are a good knowledge of basic measure and integration theory as well as the fundamentals of Lorentz geometry. The necessary background from the theory of partial differential equations and Lorentz geometry is included.
This book explains the basic concepts of Selective Decontamination of the Digestive tract (SDD) to help those involved in treating critically ill patients to improve outcomes and the quality of care. SDD has led to major changes in our understanding, the treatment and prevention of infections in critically ill patients over the past 40 years. It is the most studied intervention in intensive care medicine and is the subject of 73 randomized controlled trials, including over 15000 patients and 15 meta-analyses. SDD reduces morbidity and mortality, is cost-effective and safe as SDD does not increase antimicrobial resistance. Correct application of the SDD strategy enables ICU teams to control infections – even in ICUs with endemic antibiotic resistant microorganisms such as methicillin resistant S. aureus (MRSA). Describing the concept and application of SDD, and presenting case studies and microbiological flow charts, this practical guide will appeal to intensivists, critical care practitioners, junior doctors, microbiologists and ICU-nurses as well as infection control specialists and pharmacists.
This volume treats the acyclic sulfur(II)-nitrogen compounds with one-coordinate and two-coordinate sulfur. Sulfur imide (S=NH) and N-organyl-sulfur imides (S=NR) are unstable compounds which can be stabilized by coordination to transition metals or trapped, for example, by Ä2 + 4Ü cycloaddition with 1,3-butadiene. Among dithionitryl (1+) salts, only ÄS=N=SÜ+AsF6- has been studied extensively. Cycloaddition with alkenes and triple bond compounds produce 1,3,2-dithiazolium salts. Thiohydroxylamine, HSNH2, has been detected in the gas phase. Numerous examples of N, N-diorganyl-amino-halogeno-sulfanes (XSNR2, X = F, Cl, Br, I; R = organyl) and salts of the cation (XS)2N+ (X = Cl, Br) are known. N, N-Diorganyl-amino-chloro-sulfanes are important synthetic reagents.
Fam's Musculoskeletal Examination and Joint Injection Techniques provides cutting-edge content and clear, clinical advice on joint injection techniques and performing the musculoskeletal exam. George V. Lawry, Hans J. Kreder, Gillian Hawker, and Dana Jerome present full-color photographs and illustrations demonstrating musculoskeletal (MSK) exam and joint injection techniques for step-by-step guidance...in print and online. - Master applied anatomy through discussions of basic biology, anatomy, and functions of the musculoskeletal system. - Apply anatomy skills in aspiration/injection techniques of both the joint and periarticular structures. - Perform and interpret the physical exam thanks to step-by-step how-to guidance. - Visualize anatomic landmarks in precise detail using the rich, full-color photographs and illustrations. - Find up-to-date material on common abnormal conditions for every joint and easily identify each one. Access information easily with coverage of examination and injection techniques, organized by body region. - Tap into multidisciplinary viewpoints from rheumatology, orthopaedics, and other health professions including physical therapy and chiropractice. - Perform exams more effectively with evidence-based findings throughout the text. - Apply cutting-edge knowledge on injection techniques to your practice. - See physicians performing injections and parts of the musculoskeletal exam in full-color "action" shots. - View videos of injection procedures online at expertconsult.com that reinforce concepts from the text.
Stress in Health and Disease presents the principal pathways mediating the response to a stressor. It discusses the clinical background of cross-resistance and treatment with stress-hormones. It addresses the diseases of adaptation or stress diseases, diagnostic indicators, and functional changes. Some of the topics covered in the book are the concept of heterostasis; stressors and conditioning agents; morphology of frostbite; characteristics manifestations of stress; catecholamines and their derivatives; various hormones and hormone-like substances; FFA, triglycerides and lipoproteins; morphologic changes; and hypothalamo-hypophyseal system . The gastrointestinal diseases of adaptation are covered. The schizophrenia and related psychoses is discussed. The text describes the manic-depressive disease and senile psychosis. A study of the experimental cardiovascular diseases and neuropsychiatric diseases is presented. A chapter is devoted to the diseases of adaptation in animals. Another section focuses on the shift in adenohypophyseal activity and catatoxic hormones. The book can provide useful information to scientists, doctors, students, and researchers.
Serving as a general introduction to surface and interface science, this book focuses on essential concepts rather than specific details, on intuitive understanding rather than learning facts. The text reflects the fact that the physics and chemistry of surfaces is a diverse field of research and shows this in its Interdisciplinary conceptual design. Once the most important techniques and methods have been introduced, readers will be able to apply simple models to their own scientific problems. Furthermore, manifold high-end technological applications from surface technology, biotechnology, or microelectronics illustrate the basic scientific treatment. The authors address advanced students of chemistry, physics, materials science, chemical engineering and related subjects with a basic knowledge of natural sciences and mathematics, since the mathematical calculations are thoroughly explained and made comprehensible for the reader. As such, non-specialists in surface science who want to learn more about this important subject will also benefit from the book.
The present volume is the first of a series describing acyclic sulfur-nitrogen compounds with sulfur of oxidation number IV. The acyclic sw-N compounds are arranged according to the coordination number of the sulfur. Neutral compounds are described before ions and complex compounds. The preceding series "Sulfur-Nitrogen Compounds" Parts 2, 3, and 4 covers the cyclic sw-N compounds. In this volume, the first section deals with sulfur-nitrogen compounds with 1-coordinate sulfur and begins with the sulfur nitride {thiazyl) radical, SN. This transient molecule was observed in its electronic ground state and several electronically excited states. The descrip tions of the sulfur nitride (thiazyl) ions SN+ and SW follow. The SN+ ionwas studied in the gas phase as weil as in the solid state where it forms salts. Thionitrosyl complexes containing the SN Iigand as a terminal linear unit are described at the end of the first section. The second section concerns Sulfur-nitrogen compounds with 2-coordinate sulfur and starts with the description of poly(sulfur nitride), (SNlx· The preparation, crystal structure, and metallic and superconducting properties of (SN)x, which were extensively studied, fill a !arge part of the volume. Halogen-modified poly(sulfur nitride) such as the widely studied (SNBr )x 04 and Na-modified poly(sulfur nitride) are dealt with in the following chapters.
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