Hans Clevers's Books

Stem Cells

Scientific Facts and Fiction

By: Christine L. Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers

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Stem Cells

Scientific Facts and Fiction

By: Christine L. Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers

The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. - Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy - Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice - Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice

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Page Count

446

Publisher

Academic Press

Published Date

ISBN 10

0124115675

ISBN 13

9780124115675

Immunological Aspects of Neoplasia — The Role of the Thymus

By: Bela Bodey,Stuart E. Siegel,Hans E. Kaiser

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Immunological Aspects of Neoplasia — The Role of the Thymus

By: Bela Bodey,Stuart E. Siegel,Hans E. Kaiser

Our work began where the greatest classical morphologists left off; their best work was the start of ours. As our work progressed, the rigidity of basic, previous embryological principles was broken down as scientific knowledge advanced. At the same time, the molecular, biological characterization of the cell surface receptor systems progressed enormously with the invention of NUMEROUS monoclonal antibodies. Thus, thymology became once again very important because the thymus is the first and central organ of the human immunological system. Then, the question of immuno-neuroendocrine regulation arose and has only been partially answered. Our book seeks to explore what has not been explored. The topic of thymic epithelial cells is a unique one and has never been explored in any previous book as it is explored in this one. Only a handful of great thymologists remain in the world today, especially after the great loss the medical community suffered with the passing of Dr. Good, the list includes but is not limited to: Dr. Ritter and Dr. Kendall in England, Dr. Savino in Brazil, Dr. Dardenne in France, Dr. von Gaudecker in Germany, a few others in Belgium and Holland, and it is our hope that Dr. Bodey is among them. Nonetheless, a book on the thymus has not been written in the last five years and a book such as this one has never been. This book is based on a 30-year period of research and includes references from a broad range of sources spanning the globe and all sources, even those that were the beginning of thymic research. The book, thus, is uniquely well rounded, more so that previous works.

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Page Count

212

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1402021852

ISBN 13

9781402021855

Primary Immunodeficiency Diseases

A Molecular & Cellular Approach

By: Hans D. Ochs,C. I. Edward Smith,Jennifer M. Puck

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Primary Immunodeficiency Diseases

A Molecular & Cellular Approach

By: Hans D. Ochs,C. I. Edward Smith,Jennifer M. Puck

The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.

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Page Count

745

Publisher

Oxford University Press

Published Date

ISBN 10

0199747962

ISBN 13

9780199747962

Clinical Neuroembryology

Development and Developmental Disorders of the Human Central Nervous System

By: Hans J. ten Donkelaar,Martin Lammens,Akira Hori

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Clinical Neuroembryology

Development and Developmental Disorders of the Human Central Nervous System

By: Hans J. ten Donkelaar,Martin Lammens,Akira Hori

This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These chapters are abundantly illustrated in colour with carefully chosen clinical case studies with imaging data, and when available, postmortem verification of the developmental disorders involved. In the third edition, more emphasis has been given to the developmental ontology based on the prosomeric approach, and fetal development. Prenatal diagnosis by ultrasound, MRI and DTI, and classifications of developmental disorders have been updated. A number of new Clinical Cases have been included. Several new co-authors participate in various chapters. The book is intended for advanced medical students, and all those clinicians working with children and adults with developmental disorders of the CNS. Unique to the book is the integration of data from human embryology, experimental and molecular findings in mice in particular, imaging and developmental neuropathology.

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Page Count

926

Publisher

Springer Nature

Published Date

ISBN 10

3031260988

ISBN 13

9783031260988

Stem Cells

Scientific Facts and Fiction

By: Christine L. Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers

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Stem Cells

Scientific Facts and Fiction

By: Christine L. Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers

Stem Cells: Scientific Facts and Fiction, Third Edition, provides a state-of-the-art overview on the field of stem cells and their current applications. The book incorporates the history and firsthand commentaries in the field from clinical and research leaders, covering interesting topics of note, including the first clinical trials to treat Parkinson disease, macular degeneration, and corneal replacement, the cloning of monkeys, the organoid field, and CRISPR-edited genomics. In addition, coverage of adult, embryonic stem cells and iPS cells is included. This new edition distinguishes itself from the multiplicity of websites about stem cells with a broad view of the field. - Explains, in a straightforward, nonspecialist language, the basic biology of stem cells and their applications in modern medicine and future therapy - Provides new and expanded coverage of cloning, organoids, "synthetic embryos, and much more - Includes detailed illustrations to assist users with learning on how research is done

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Page Count

423

Publisher

Academic Press

Published Date

ISBN 10

0128226773

ISBN 13

9780128226773

Book's by Hans Clevers

Stem Cells

Stem Cells

Immunological Aspects of Neoplasia — The Role of the Thymus

Immunological Aspects of Neoplasia — The Role of the Thymus

Primary Immunodeficiency Diseases

Primary Immunodeficiency Diseases

Clinical Neuroembryology

Clinical Neuroembryology

Stem Cells

Stem Cells

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