This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in diagnostics and prognostics, as well as novel drug targets. The conventional techniques used for miRNA detection including standard PCR, Northern blotting, microarray and clone methods are addressed. Recent emerging strategies in miRNA detection and quantification with superior flexibility and adaptability, such as novel molecular biological techniques and locked nucleic acid (LNA) modified probes, as well as nanotechnology-based approaches, are also included. The book also highlights the latest advances in clinical-related miRNA detection methods in living cells, circulating blood and tissue, such as in situ hybridization (ISH) and molecular imaging techniques, which are useful to elucidate the biogenesis and biological function of miRNAs in vivo. Finally, the respective advantages and drawbacks of various detection techniques in this fast-moving field are discussed, along with the challenges and promising new directions. This book offers a valuable resource for analytical chemists, biologists and physicians involved in miRNA research. Dr. Xueji Zhang and Dr. Haifeng Dong are Professors at the School of Chemistry & Biological Engineering, University of Science & Technology Beijing (USTB), China. Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China.
This book investigates uneven regional development in China – with particular focus on the cases of Guangdong and Zheijiang provinces – which have been at the forefront of debate since Chinese economic reform. Rapid economic growth since the ‘opening-up’ of China has been accompanied by significant disparities in the regional distribution of income: this book represents one of the most recent studies to present a picture of this inequality. Built upon a multi-scale and multi-mechanism framework, it provides systematic examination of both the patterns and mechanisms of regional development and inequality in provincial China, emphasizing the effects of economic transition. Approaching from a geographical perspective, its authors consider the interplay between the local, the state, and the global forces in shaping the landscape of regional inequality in China. Extensive empirical findings will prove useful to those researching other developing countries within the frontier of globalization and economic transition. Regional Inequality in Transitional China will appeal to scholars and students of geography, economics and Chinese studies more broadly.
Advances in Lithium-Ion Batteries for Electric Vehicles: Degradation Mechanism, Health Estimation, and Lifetime Prediction examines the electrochemical nature of lithium-ion batteries, including battery degradation mechanisms and how to manage the battery state of health (SOH) to meet the demand for sustainable development of electric vehicles. With extensive case studies, methods and applications, the book provides practical, step-by-step guidance on battery tests, degradation mechanisms, and modeling and management strategies. The book begins with an overview of Li-ion battery aging and battery aging tests before discussing battery degradation mechanisms and methods for analysis. Further methods are then presented for battery state of health estimation and battery lifetime prediction, providing a range of case studies and techniques. The book concludes with a thorough examination of lifetime management strategies for electric vehicles, making it an essential resource for students, researchers, and engineers needing a range of approaches to tackle battery degradation in electric vehicles. - Evaluates the cause of battery degradation from the material level to the cell level - Explains key battery basic lifetime test methods and strategies - Presents advanced technologies of battery state of health estimation
Liquid crystal (LC) displays dominating in the present market of flat panel displays are generally based on interactions of light and LCs. Recent progress in this field indicates that integrating photochromic molecules into LC materials enables one to photomanipulate unique features such as photoinduced phase transition, photocontrolled alignment,
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