Originally taught mainly in business schools, supply chain management has become a common elective and graduate course in engineering colleges. The increasing demand for engineers with supply chain knowledge has fed this shift. However, supply chain management textbooks that have a reasonable coverage of quantitative analysis techniques are few and
Written with undergraduate students in mind, the new edition of this classic textbook provides a compact introduction to the physiology of nerve and muscle. It gives a straightforward account of the fundamentals accompanied by some of the experimental evidence upon which this understanding is based. It first explores the nature of nerve impulses, clarifying their mechanisms in terms of ion flow through molecular channels in cell membranes. There then follows an account of the synaptic transmission processes by which one excitable cell influences activity in another. Finally, the emphasis turns to the consequences of excitable activity in the activation of contraction in skeletal, cardiac and smooth muscle, highlighting the relationships between cellular structure and function. This fourth edition includes new material on the molecular nature of ion channels, the activation of skeletal muscle and the function of cardiac and smooth muscle, reflecting exciting new developments in these rapidly growing fields.
Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies.
A groundbreaking and superlatively accurate new translation of Laozi’s The Dao De Jing, from the bestselling translator of The Art of War, promising to be the first English edition based on direct translation from the oldest known copies of the ancient Chinese text. One of the most significant and popular books in the history of human thought, and China’s earliest philosophical classic, The Dao De Jing has served for millennia as a brilliant guide to living healthily and happily, to treating the Earth with respect, and to understanding our place in the cosmos. The Dao is as vitally important to today’s world as it was during the Bronze Age, presenting us with clear and unexpectedly sane answers to some of the most pressing questions and challenges of our time. This beloved classic teaches us to become one with nature, with all people, and with the world; with the ultimate intention of illuminating the path to peace and promoting the conditions for harmony—within the self and in the greater world around us. Renowned translator J. H. Huang has spent over two decades researching the Dao, resulting in the most accurate translation to date based on the oldest known transcripts of the text. Huang’s translation is the first to incorporate four major archaeological findings, which have been preserved for millennia in ancient tombs, most of which were only discovered in the late twentieth century: the Guodian Chu slips, the Mawangdui silk texts, the Fu Yi version, and the Peking University bamboo slips. Huang argues that these key source materials “contextualize The Dao De Jing much in the same way the Dead Sea Scrolls illuminate the New Testament.” The result is a groundbreaking translation that offers readers the first opportunity in over two millennia to thoroughly comprehend all of the teachings contained in these eighty-one chapters.
This well-established and acclaimed textbook introducing the rapidly growing field of nerve and muscle function has been completely revised and updated. Written with undergraduate students in mind, it begins with the fundamental principles demonstrated by the pioneering electrophysiological experiments on cell excitability. This leads to more challenging material recounting recent discoveries from applying modern biochemical, genetic, physiological and biophysical, experimental and mathematical analysis. The resulting interdisciplinary approach conveys a unified contemporary understanding of nerve and skeletal, cardiac and smooth muscle function at the molecular, cellular and systems levels. Emphasis on important strategic experiments throughout clarifies the basis for our current scientific views, highlights the excitement and challenge of biomedical discovery, and suggests directions for future advances. These fundamental ideas are then translated into discussions of related disease conditions and their clinical management. Now including colour illustrations, it is an invaluable text for students of physiology, neuroscience, cell biology and biophysics.
With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future
This book was written to provide a clear and systematic sum mary of the principles of gynaecology in synoptic form. It is part of a three volume series, the first two volumes covering topics in undergraduate obstetricE! and neonatal medicine respectively. Where appropriate, fundamentals of related anatomy and physiology are also covered. It is primarily directed at under graduate medical students and midwives, but material useful as reference to doctors revising for further qualifications has been included. Although much of the content is organized in the form of lists, this book differs from the usual 'list' book in that cover age is full and systematic. Thus the text has been organized into the following subheadings, where appropriate: Definitions, Aetiology, Pathophysiology, Clinical features, Differential Diag nosis, Investigations, Treatment, and Prognosis. To avoid rep etition, certain clinical areas including ectopic pregnancy and abortion which have been covered in the earlier volumes are not included. Certain useful diagnostic lists are also provided, and, in pre paring the book, previous examination papers of the Univer sities of Oxford, Cambridge and London, as well as of the Central Midwives Board, were consulted. Illustrations have been specially prepared in the form of explanatory line drawings that are simple, and easy to memorize and reproduce. Although drug dosages were checked with care before going to press, changes in medical practice make it advisable to verify regimes and doses with the latest prescribing information and the pharmacopoeia, before use.
Every trainee in anaesthesia requires a thorough understanding of basic physiology and its application to clinical practice. This comprehensively illustrated textbook bridges the gap between medical school and reference scientific texts. It covers the physiology requirements of the Primary FRCA examination syllabus. Chapters are organised by organ system, with particular emphasis given to the respiratory, cardiovascular and nervous systems. The practical question-and-answer format helps the reader prepare for the oral examination, while 'clinical relevance' boxes translate the physiological concepts to clinical practice. The authors include two medical physiologists and a Specialty Registrar in anaesthesia, and thereby bring a unique blend of expertise. This ensures that the book is up-to-date, accessible, and pitched appropriately for the trainee anaesthetist. Packed with easily understood, up-to-date and clinically relevant material, this convenient volume provides an essential 'one-stop' resource in physiology for junior anaesthetists.
Low-pressure (LP) membrane use has increased dramatically over the last decade in response to more stringent pathogen-related drinking water regulations, water reclamation and the need for more effective reverse osmosis pretreatment, and from dramatically reduced membrane costs. More cost-effective and reliable operation of LP membrane systems is constrained, however, by fouling, in particular fouling by NOM. NOM fouling is poorly understood because of both the complexity and types of NOM that exists in natural sources and wastewater effluent and NOM-membrane interactions. This report is available as a Pay-Per-View item only. NOM exists in three primary forms (allochthonous, autochthonous, and effluent-derived), with a variety of components having differing fouling tendencies. LP membranes comprise hollow fibers of differing polymeric materials, with a range of properties that likewise influence fouling propensity. Fouling management strategies (backwash, air scrub, chemical cleaning) employed with LP membrane systems differ from supplier to supplier. This, combined with a number of the methods used to reduce NOM levels prior to membrane treatment (e.g., coagulation, clarification), further complicate the understanding of NOM fouling. The overall goal of this project was to investigate the specific contributions of the different types of natural organic matter (NOM) to microfiltration/ultrafiltration (MF/UF) fouling. The intent was to develop a surrogate test or index that could be used to predict NOM fouling at low cost through a combination of source water characterization and rapid bench-scale testing. The research incorporated bench-, pilot- and full-scale investigations. Testing was conducted with four source waters, selected to capture the fouling characteristics of the three primary types of NOM. Bench testing use a stirred, cell apparatus and three flat sheet membrane types, representing commercially dominant MF and UF hollow fiber membranes of the same polymer types. Hollow fiber bench testing used two PVDF and two PES membranes operated in both sequential and alternating filtration/backwash mode. Pilot testing included PVDF MF and UF and PES UF systems operated on three of the four source waters and incorporated a host of fouling management strategies. Full-scale investigations captured operating data from several plants having differing levels and types of NOM.
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