H. Grunicke's Books

P.J. Pearson, P.M. Vanhoutte: Vasodilator and Vasoconstrictor Substances Produced by the Endothelium. L. Dux: Muscle Relaxation and Sarcoplasmic Reticulum Function in Different Muscle Types. C.C. Ashley, P.J. Griffith, T.J. Lea, I.P. Mulligan, R.e. Palmer, and S.J. Simnett: Barnacle Muscle: Ca2+ Activation and Mechanics.

In this volume of Reviews of Physiology, Biochemistry and Pharmacology there a contributions by M.D. Swope, E. Lolis, F.Hofmann, L. Lacinova, N. Klugbauer, M. Hermann, P. Berger, S.S. Shen, J.S. Kim, M.E. Weksler, M. Hirsch-Kauffmann and M.Schweiger.

W. Ulbricht: Effects of veratridine on sodium currents and fluxes. W. Meyerhof: The elucidation of somatostatin receptor functions: a current view.M. Leist, F. Gantner, g. Künstle and A. Wendel: Cytokine-mediated hepatic apoptosis.

With contributions by numerous experts

This special volume provides up-to-date information on research dealing with the regulation of the biosynthesis and degradation of cyclic GMP and with the regulation of physiological systems by cyclic GMP. The publication of this volume could not have come at a more appropriate time, with significant work in this area having led to our current understanding of the role of nitric oxide in signal transduction, and the 1998 Nobel Prize in Medicine and Physiology for Furchgott, Murad and Ignarro. Moreover, the introduction in early 1998 of sildenafil (Viagra), a selective inhibitor of a cyclic GMP phosphodiesterase, for the treatment of erectile dysfunction in men represents the first successful therapeutic application of an agent designed to alter the activity of a molecular target in a cyclic GMP pathway.

The objectives in this special issue are (1) to critically review current information on the mechanisms coupling extracellular regulatory signals to regulation of cross-bridge cycling and proliferation in smooth muscle, and (2) identify significant gaps or unresolved issues that are important topics for future research. The experimental and analytical difficulties discussed above are increasingly recognized and surmounted. Elucidation of the molecular and cellular events underlying the biologal properties of smooth muscle is in the midst of a period of rapid progress. While the reviews reveal many gaps to be filled and illustrate areas of contention, they also capture the excitement of new discoveries.

Book's by H. Grunicke

Reviews of Physiology, Biochemistry and Pharmacology

Reviews of Physiology, Biochemistry and Pharmacology

Reviews of Physiology, Biochemistry and Pharmacology 139

Reviews of Physiology, Biochemistry and Pharmacology 139

Reviews of Physiology, Biochemistry and Pharmacology

Reviews of Physiology, Biochemistry and Pharmacology

Reviews of Physiology, Biochemistry and Pharmacology 149

Reviews of Physiology, Biochemistry and Pharmacology 149

Reviews of Physiology, Biochemistry and Pharmacology

Reviews of Physiology, Biochemistry and Pharmacology

Reviews of Physiology Biochemistry and Pharmacology

Reviews of Physiology Biochemistry and Pharmacology

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