Guosheng Yin's Books

Clinical Trial Design

Bayesian and Frequentist Adaptive Methods

By: Guosheng Yin

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Clinical Trial Design

Bayesian and Frequentist Adaptive Methods

By: Guosheng Yin

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.

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Page Count

368

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118183320

ISBN 13

9781118183328

Clinical Trial Design

Bayesian and Frequentist Adaptive Methods

By: Guosheng Yin

Write a review Read reviews Take a Quiz Solve Book Puzzle

Clinical Trial Design

Bayesian and Frequentist Adaptive Methods

By: Guosheng Yin

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

368

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118183320

ISBN 13

9781118183328

Non-driven Micromechanical Gyroscopes and Their Applications

By: Fuxue Zhang,Wei Zhang,Guosheng Wang

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Non-driven Micromechanical Gyroscopes and Their Applications

By: Fuxue Zhang,Wei Zhang,Guosheng Wang

This book comprehensively and systematically introduces readers to the theories, structures, performance and applications of non-driven mechanical and non-driven micromechanical gyroscopes. The book is divided into three parts, the first of which mainly addresses mathematic models, precision, performance and operating error in non-driven mechanical gyroscopes. The second part focuses on the operating theory, error, phase shift and performance experiments involving non-driven micromechanical gyroscopes in rotating flight carriers, while the third part shares insights into the application of non-driven micromechanical gyroscopes in control systems for rotating flight carriers. The book offers a unique resource for all researchers and engineers who are interested in the use of inertial devices and automatic control systems for rotating flight carriers. It can also serve as a reference book for undergraduates, graduates and instructors in related fields at colleges and universities.

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Page Count

367

Publisher

Springer

Published Date

ISBN 10

3662540452

ISBN 13

9783662540459

Book's by Guosheng Yin

Clinical Trial Design

Clinical Trial Design

Clinical Trial Design

Clinical Trial Design

Non-driven Micromechanical Gyroscopes and Their Applications

Non-driven Micromechanical Gyroscopes and Their Applications

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