Gordon S. Rule's Books

Fundamentals of Protein NMR Spectroscopy

By: Gordon S. Rule,T. Kevin Hitchens

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Fundamentals of Protein NMR Spectroscopy

By: Gordon S. Rule,T. Kevin Hitchens

NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.

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Page Count

543

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1402035004

ISBN 13

9781402035005

Outsiders

Five Women Writers Who Changed the World

By: Lyndall Gordon

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Outsiders

Five Women Writers Who Changed the World

By: Lyndall Gordon

Prodigy, visionary, 'outlaw,' orator and explorer. As society's outsiders, the exceptional subjects of this study inspired a new breed of women—and one another. Finalist of the PROSE Award for Best Book in Literature by the Association of American Publishers Mary Shelley, Emily Brontë, George Eliot, Olive Schreiner and Virginia Woolf: they all wrote dazzling books that forever changed the way we see history. In Outsiders, award-winning biographer Lyndall Gordon shows how these five novelists shared more than talent. In a time when a woman's reputation was her security, each of these women lost hers. They were unconstrained by convention, writing against the grain of their contemporaries, prophetically imagining a different future. We have long known the individual greatness of each of these writers, but in linking their creativity to their lives as outcasts, Gordon throws new light on the genius they share. All five lost their mothers in childbirth or at a young age. With no female role model present, they learned from books—and sometimes from an enlightened mentor. Crucially, each had to imagine what a woman could be in order to invent a voice of her own. The passion in their own lives infused their fiction. Writing with passionate intelligence of her own, Gordon reveals that these renegade writers inspired a new breed of women who wished to change a world locked in war, violence, exploitation, and sexual abuse. Gordon's biographies have always shown the indelible connection between life and art: an intuitive, exciting and revealing approach that has been highly praised. In Outsiders, she crafts nuanced portraits of Shelley, Brontë, Eliot, Schreiner and Woolf, naming each of these writers as prodigy, visionary, 'outlaw,' orator, and explorer, and shows how they came, they saw, and they left us changed. Today, following the tsunami of women's protest at widespread abuse, we do more than read them; we listen and live with their astonishing bravery and eloquence.

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