Gordon M Shepherd's Books

Neurogastronomy

How the Brain Creates Flavor and Why It Matters

By: Gordon Shepherd

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Neurogastronomy

How the Brain Creates Flavor and Why It Matters

By: Gordon Shepherd

Leading neuroscientist Gordon M. Shepherd embarks on a paradigm-shifting trip through the "human brain flavor system," laying the foundations for a new scientific field: neurogastronomy. Challenging the belief that the sense of smell diminished during human evolution, Shepherd argues that this sense, which constitutes the main component of flavor, is far more powerful and essential than previously believed. Shepherd begins Neurogastronomy with the mechanics of smell, particularly the way it stimulates the nose from the back of the mouth. As we eat, the brain conceptualizes smells as spatial patterns, and from these and the other senses it constructs the perception of flavor. Shepherd then considers the impact of the flavor system on contemporary social, behavioral, and medical issues. He analyzes flavor's engagement with the brain regions that control emotion, food preferences, and cravings, and he even devotes a section to food's role in drug addiction and, building on Marcel Proust's iconic tale of the madeleine, its ability to evoke deep memories. Shepherd connects his research to trends in nutrition, dieting, and obesity, especially the challenges that many face in eating healthily. He concludes with human perceptions of smell and flavor and their relationship to the neural basis of consciousness. Everyone from casual diners and ardent foodies to wine critics, chefs, scholars, and researchers will delight in Shepherd's fascinating, scientific-gastronomic adventures.

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286

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Columbia University Press

Published Date

ISBN 10

0231159110

ISBN 13

9780231159111

Creating Modern Neuroscience: The Revolutionary 1950s

By: Gordon M. Shepherd

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Creating Modern Neuroscience: The Revolutionary 1950s

By: Gordon M. Shepherd

For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the cortical column (Mountcastle), reticular activating system (Morruzzi and Magoun) and REM sleep (Aserinsky), to stress (Selye), learning (Hebb) and memory (HM and Milner). The clinical fields are also covered, from Cushing and Penfield, psychosurgery and brain energy metabolism (Kety), to most of the major psychoactive drugs in use today (beginning with Delay and Deniker), and much more.The material has been the basis for a highly successful advanced undergraduate and graduate course at Yale, with the classic papers organized and accessible on the web. There is interest for a wide range of readers, academic, and lay because there is a focus on the creative process itself, on understanding how the combination of unique personalities, innovative hypotheses, and new methods led to the advances. Insight is given into this process through describing the struggles between male and female, student and mentor, academic and private sector, and the roles of chance and persistence. The book thus provides a new multidisciplinary understanding of the revolution that created the modern field of neuroscience and set the bar for judging current and future advances.

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337

Publisher

Oxford University Press

Published Date

ISBN 10

0195391500

ISBN 13

9780195391503

Neurobiology

By: Gordon M. Shepherd

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Neurobiology

By: Gordon M. Shepherd

The second edition of this highly acclaimed textbook was thoroughly revised to incorporate a multitude of recent research findings in neuroscience. A new chapter on molecular neurobiology was added and the basic concepts of the synapse, impulse, neurotransmitters, and neuromodulators were put on a molecular basis. The author greatly extended the treatment of developmental and memory mechanisms and also introduced the field of neuroimmunology.

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Page Count

689

Publisher

Oxford University Press, USA

Published Date

ISBN 10

0195051726

ISBN 13

9780195051728

Foundations of the Neuron Doctrine

By: Gordon M. Shepherd

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Foundations of the Neuron Doctrine

By: Gordon M. Shepherd

The neuron doctrine, first formulated in 1891, states that the brain is constructed of individual neurons, organized into functioning circuits that mediate behavior. Above all else, this is the main concept that underlies all of modern neuroscience. This 25th Aniversary Edition of The Foundations of the Neuron Doctrine explains how this theory was the product of an explosion of histological studies and vigorous debates near the end of the nineteenth century by an extraordinary group of scientists, most importantly the leading figure of the time, Santiago Ramon y Cajal of Spain, and includes the foremost nervous system investigators of many countries, such as Albrecht Kolliker, Sigmund Freud, Wilhelm His, August Forel, Fritdjof Nansen and Gustav Retzius.

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Page Count

385

Publisher

Oxford University Press, USA

Published Date

ISBN 10

0190259388

ISBN 13

9780190259389

Creating Modern Neuroscience: The Revolutionary 1950s

By: Gordon M. Shepherd

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Creating Modern Neuroscience: The Revolutionary 1950s

By: Gordon M. Shepherd

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337

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Oxford University Press

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ISBN 10

0195391500

ISBN 13

9780195391503

Foundations of the Neuron Doctrine

By: Gordon M. Shepherd

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Foundations of the Neuron Doctrine

By: Gordon M. Shepherd

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385

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Oxford University Press, USA

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ISBN 10

0190259388

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9780190259389

Neurogastronomy

How the Brain Creates Flavor and Why It Matters

By: Gordon Shepherd

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Neurogastronomy

How the Brain Creates Flavor and Why It Matters

By: Gordon Shepherd

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286

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Columbia University Press

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ISBN 10

0231159110

ISBN 13

9780231159111

Angelo Mosso's Circulation of Blood in the Human Brain

By: Marcus E. Raichle,Gordon M. Shepherd

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Angelo Mosso's Circulation of Blood in the Human Brain

By: Marcus E. Raichle,Gordon M. Shepherd

Modern brain imaging is revolutionizing the study of brain function in health and disease. However, few realize that its origins began in the nineteenth century with Dr. Angelo Mosso's pioneering experiments. A foremost Italian physiologist and scientist, Angelo Mosso studied several patients brought to him with head injuries that exposed their live brains to direct, long-term observation. He took advantage of these rare opportunities to document, for the first time, changes in cerebral blood flow in response to different stimuli, behaviors, and emotions, the very same changes that are now the basis for the measurements underlying modern functional brain imaging. Mosso was widely recognized by his contemporaries for his highly original studies, published both in Italian in 1878 and in German in 1881. Yet there has never been a translation through which this groundbreaking work could be appreciated by the English-speaking world. Indeed, Angelo Mosso's sophisticated experiments were to neuroscience what surgeon William Beaumont's in vivo observations were to gastric physiology fifty years earlier. This unique monograph establishes Mosso's rightful role as the pioneer of brain imaging. Through it, the modern reader, whether expert neuroscientist or interested student, can gain a new perspective on the author's remarkable insights: how behaviors as subtle as thinking about a subject or feeling an emotion produce the changes in pulsations of the brain that he observed and recorded for posterity. Special features of this volume include first a brief summary of Mosso's life. Two pioneers of modern brain imaging, Marcus E. Raichle (winner of the Kavli Prize for Neuroscience) and Gordon M. Shepherd (Yale University Professor of Neurobiology) then review Mosso's work and provide extensive commentary to explain its relevance to modern brain science. The authors not only emphasize Mosso's pioneering role in brain imaging, but also his fundamental contribution to the rise of cognitive neuroscience. The English translation (by historian of medicine Christiane Nockels Fabbri) follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience, now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public.

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241

Publisher

Oxford University Press

Published Date

ISBN 10

0199359008

ISBN 13

9780199359004

How to Use Evidence-Based Dental Practices to Improve Clinical Decision-Making

By: American Dental Association,Alonso Carrasco-Labra,Romina Brignardello-Petersen,,Michael Glick,Amir Azarpazhooh,Gordon Guyatt

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How to Use Evidence-Based Dental Practices to Improve Clinical Decision-Making

By: American Dental Association,Alonso Carrasco-Labra,Romina Brignardello-Petersen,,Michael Glick,Amir Azarpazhooh,Gordon Guyatt

This book is a one-stop resource for learning how to harness the power of the latest scientific information and optimize patient care. How to Use Evidence-Based Dental Practices to Improve Your Clinical Decision-Making is the definitive resource for dental students and practitioners who want to learn from leaders in the field of evidence-based dentistry (EBD); quickly conduct searches for the latest research; master the skill of critically appraising clinical studies; confidently apply the latest research to patient care; teach others how to inform their practice with the latest clinical evidence; and access everything they need to become an EBD all-star. The ADA Center for Evidence-Based Dentistry oversaw the development of this publication. Dental teams and educators alike will find it a useful resource for incorporating the most up-to-date scientific evidence in clinical decisions and instilling others with the curious mindset needed to provide evidence-based health care. Includes link to e-book.

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Page Count

437

Publisher

American Dental Association

Published Date

ISBN 10

1684470625

ISBN 13

9781684470624

Organic Bionics

By: Gordon G. Wallace,Simon E. Moulton,Robert M.I. Kapsa,Michael Higgins

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Organic Bionics

By: Gordon G. Wallace,Simon E. Moulton,Robert M.I. Kapsa,Michael Higgins

The first reference on this emerging interdisciplinary research area at the interface between materials science and biomedicine is written by pioneers in the field, who address the requirements, current status and future challenges. Focusing on inherently conducting polymers, carbon nanotubes and graphene, they adopt a systematic approach, covering all relevant aspects and concepts: synthesis and fabrication, properties, introduction of biological function, components of bionic devices and materials requirements. Established bionic devices, such as the bionic ear are examined, as are emerging areas of application, including use of organic bionic materials as conduits for bone re-growth, spinal cord injury repair and muscle regeneration. The whole is rounded off with a look at future prospects in sustainable energy generation and storage. Invaluable reading for materials scientists, polymer chemists, electrotechnicians, chemists, biologists, and bioengineers.

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241

Publisher

John Wiley & Sons

Published Date

ISBN 10

3527328823

ISBN 13

9783527328826

Neuroenology

How the Brain Creates the Taste of Wine

By: Gordon M. Shepherd

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Neuroenology

How the Brain Creates the Taste of Wine

By: Gordon M. Shepherd

In his new book, Gordon M. Shepherd expands on the startling discovery that the brain creates the taste of wine. This approach to understanding wine's sensory experience draws on findings in neuroscience, biomechanics, human physiology, and traditional enology. Shepherd shows, just as he did in Neurogastronomy: How the Brain Creates Flavor and Why It Matters, that creating the taste of wine engages more of the brain than does any other human behavior. He clearly illustrates the scientific underpinnings of this process, along the way enhancing our enjoyment of wine. Neuroenology is the first book on wine tasting by a neuroscientist. It begins with the movements of wine through the mouth and then consults recent research to explain the function of retronasal smell and its extraordinary power in creating wine taste. Shepherd comprehensively explains how the specific sensory pathways in the cerebral cortex create the memory of wine and how language is used to identify and imprint wine characteristics. Intended for a broad audience of readers—from amateur wine drinkers to sommeliers, from casual foodies to seasoned chefs—Neuroenology shows how the emotion of pleasure is the final judge of the wine experience. It includes practical tips for a scientifically informed wine tasting and closes with a delightful account of Shepherd's experience tasting classic Bordeaux vintages with French winemaker Jean-Claude Berrouet of the Chateau Petrus and Dominus Estate.

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297

Publisher

Columbia University Press

Published Date

ISBN 10

0231542879

ISBN 13

9780231542876

Of Bens, Glens and Rambling Auld Men

By: Robert Scott,Gordon Nicol

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Of Bens, Glens and Rambling Auld Men

By: Robert Scott,Gordon Nicol

This starts with the early post WWII years when Robert and Gordon, as young men, were first attracted to the outdoors. They hiked and climbed in the mountains of the Scottish Highlands and often slept in caves, barns, bothies and tents in both summer and winter. They made friends and climbed with many of the emerging group of mainly working class rock climbers who were pioneering ascents of the cliffs and gullies in Glencoe and Ben Nevis at that time. Their week-end adventures had them ranging across the wild moors, glens and mountains in all seasons and in all weathers. As the years passed, their lives changed. One became a youth hostel warden in N.W. Scotland, later becoming a gamekeeper and ghillie on an estate in Assynt. The other went overseas as a teacher, first to Algeria then to Saudi Arabia and finally Brunei S.E. Asia, where he stayed for nearly thirty years. The two men lost touch with each other for over forty years. At that point they met again and, while re-calling their youthful ramblings and catching up on one another’s later adventures, came to realise the uniqueness of their lives. From these two kinds of rambling comes this fascinating book.

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376

Publisher

Troubador Publishing Ltd

Published Date

ISBN 10

1784623733

ISBN 13

9781784623739

Crofton and Douglas's Respiratory Diseases

By: Anthony Seaton,A. Gordon Leitch,Douglas Seaton

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Crofton and Douglas's Respiratory Diseases

By: Anthony Seaton,A. Gordon Leitch,Douglas Seaton

Now in its Fifth Edition, Crofton and Douglas's Respiratory Diseases has firmly established itself as the leading clinical textbook on diseases of the chest. Presented, for the first time, as a two-volume set, this classic text has been completely rewritten and greatly expanded. Extensive revisions ensure that these volumes present an up-to-date review of all aspects of lung disease . The contributions of some 18 leading authorities ensure that each area is comprehensively covered and new to this edition are chapters on the genetics of lung disease, smoking, air pollution, sleep apnoea, diving, lung transplantation and medico-legal aspects. The changes in content reflect the pace of change in the areas concerned not only in terms of understanding of the disease processes but also their treatment. The single chapter on asthma that appeared in previous editions, has now been expanded into three chapters covering epidemiology, mechanisms and management, reflecting the enormous research effort currently underway following a marked increase in the incidence of this disease in recent years. This new edition continues to provide an excellent reference both for the trainee and specialist in respiratory medicine, as well as the general physician. It will be extremely useful on the ward and in the office, where clinical problems arise and questions are asked which need clear answers.

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Page Count

1614

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470695242

ISBN 13

9780470695241

Handbook of Brain Microcircuits

By: Gordon Shepherd,Sten Grillner

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Handbook of Brain Microcircuits

By: Gordon Shepherd,Sten Grillner

Microcircuits are the specific arrangements of cells and their connections that carry out the operations unique to each brain region. This resource summarizes succinctly these circuits in over 40 regions - enabling comparisons of principles across both vertebrates and invertebrates. It provides a new foundation for understanding brain function that will be of interest to all neuroscientists. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.

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535

Publisher

Oxford University Press

Published Date

ISBN 10

0199780331

ISBN 13

9780199780334

The Pyrazines, Volume 41

By: Gordon Bruce Barlin

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The Pyrazines, Volume 41

By: Gordon Bruce Barlin

Complete coverage of chemical literature on simple pyrazines recorded in Beilstein to 1929, and Chemical Abstracts through 1978 (volume 89), together with selected references to 1980. Describes their history, occurrence, biological activity and uses, and nomenclature. Classified primary syntheses of pyrazines according to the starting materials employed. Treats primary syntheses of pyrazine N-oxides. Details syntheses, properties and reactions of alkyl, halogeno, hydroxy, mercapto, amino and carboxy pyrazines and their derivative and related compounds. Extensive table lists known simple pyrazines, physical data such as melting points and boiling points, and references.

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Page Count

714

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470188693

ISBN 13

9780470188699

Spectral Imaging of the Atmosphere

By: Gordon G. Shepherd

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Spectral Imaging of the Atmosphere

By: Gordon G. Shepherd

Optical instruments are routinely employed to obtain a wealth of information about the atmosphere, including its composition, temperature, and winds. A bewildering variety of optical instruments have been proposed over the years, making it difficult to decide which instrument should be chosen to make a specific measurement. Spectral Imaging of the Atmosphere traces the historical development of both spectral and imaging methods and places them in a unified framework relevant to observations of the troposphere, stratosphere, mesosphere and thermosphere. The underlying concepts of various measurement methodologies are presented and paired with appropriate applications. A selection of specific spectral imaging instruments, appropriate to illustrate each conceptual type, is described in detail.Shepherd's work provides both scientists and engineers with an in-depth understanding of the fundamental concepts they need to know in order to plan a program of atmospheric measurements. Expected future methods and developments are also presented. Problems designed to test and enhance the reader's understanding of the material are included in each chapter.Provides a unique and unifed approach to the methodology of optical atmospheric observations from the troposphere through the thermosphere, which allows the practitioner to choose the best instrument for a given measurement.Describes state-of-the-art atmospheric observing instruments with an eye to future developments.Includes problems designed to test and enhance students' unerstanding of the material presented in each chapter.Contains concise descriptions of selected current and planned spectral imagers, including the Fabry-Perot spectrometer, the Michelson interferometer and the diffraction grating spectrometer.Written from a scientific perspective in an engineering framework, this work is accessible to atmospheric scientists and instrumentation engineers alike.

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Page Count

340

Publisher

Elsevier

Published Date

ISBN 10

008051751X

ISBN 13

9780080517513

Synapses, Circuits, and the Beginnings of Memory

By: Gary Lynch,Gordon M. Shepherd,Ira B. Black,Herbert P. Killackey

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Synapses, Circuits, and the Beginnings of Memory

By: Gary Lynch,Gordon M. Shepherd,Ira B. Black,Herbert P. Killackey

with commentaries by Gordon M. Shepherd, Ira B. Black, and Herbert P. Killackey For years memory research focused on the neuron as the basic element of the brain, but developments in cognitive science now challenge the neurobiologist to understand the function of neural networks, perhaps one of the most difficult problems of the mind. This monograph articulates the ways in which neurobiologic discoveries can be interpreted in terms of psychological memory. The brain mechanisms of learning and memory have been extensively studied by both neuroscientists and psychologists in recent years. Here Gary Lynch outlines the main issues in this dialogue: using the olfactory cortex and related hippocampus as examples, he discusses the physiological and chemical process involved in producing long-term memory and the anatomical organization of the neuronal circuitries in which they are stored. Then, combining these arguments, Lynch arrives at a series of postulates about the dynamics of the formation, association, and recall of memory representations in cortical networks. An evolutionary theme concerning the origins of the hypothesized organizations and processes runs throughout the monograph. Commenting on some of these ideas, Gordon Shepherd (Yale University) takes up the ways particular aspects of cortical cells, the apical dendrites of pyramidal cells, can be active in storing information. Ira Black (Cornell University Medical College) discusses the biochemical mutability of individual neurons and how this must be taken into account in modeling the way neural cells support mnemonic processes. A general discussion of cortical morphology and memory is provided by Herbert Killackey (University of California, Irvine). Gary Lynch is at the Center for the Neurobiology of Learning and Memory, University of California, Irvine. Synapses, Circuits, and the Beginnings of Memoryinaugurates The Cognitive Science Institute Monographs Series, edited by Michael A. Gazzaniga. A Bradford Book.

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Page Count

124

Publisher

MIT Press (MA)

Published Date

ISBN 10

026212114X

ISBN 13

9780262121149

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