Glenn T. Lines's Books

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

By: Aslak Tveito,Glenn T. Lines

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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

By: Aslak Tveito,Glenn T. Lines

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.

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Page Count

279

Publisher

Springer

Published Date

ISBN 10

331930030X

ISBN 13

9783319300306

Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

By: Glenn Walker,Jack Shostak

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Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

By: Glenn Walker,Jack Shostak

Glenn Walker and Jack Shostak's Common Statistical Methods for Clinical Research with SAS Examples, Third Edition, is a thoroughly updated edition of the popular introductory statistics book for clinical researchers. This new edition has been extensively updated to include the use of ODS graphics in numerous examples as well as a new emphasis on PROC MIXED. Straightforward and easy to use as either a text or a reference, the book is full of practical examples from clinical research to illustrate both statistical and SAS methodology. Each example is worked out completely, step by step, from the raw data. Common Statistical Methods for Clinical Research with SAS Examples, Third Edition, is an applications book with minimal theory. Each section begins with an overview helpful to nonstatisticians and then drills down into details that will be valuable to statistical analysts and programmers. Further details, as well as bonus information and a guide to further reading, are presented in the extensive appendices. This text is a one-source guide for statisticians that documents the use of the tests used most often in clinical research, with assumptions, details, and some tricks--all in one place. This book is part of the SAS Press program.

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553

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SAS Institute

Published Date

ISBN 10

1607644258

ISBN 13

9781607644255

Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

By: Glenn A. Walker,Jack Shostak

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Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

By: Glenn A. Walker,Jack Shostak

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552

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SAS Institute

Published Date

ISBN 10

1629590312

ISBN 13

9781629590318

Great American Hypocrites

Toppling the Big Myths of Republican Politics

By: Glenn Greenwald

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Great American Hypocrites

Toppling the Big Myths of Republican Politics

By: Glenn Greenwald

A takedown of the GOP’s deceitful propaganda machine from the blogger of Salon’s Unclaimed Territory and the author of the New York Times bestsellers How Would a Patriot Act? and A Tragic Legacy. Ever since the cowboy image of Ronald Reagan was sold to Americans, the Republican Party has used the same John Wayne imagery to support its candidates and take elections. We all know how they govern, but the right-wing propaganda machine is very adept at hijacking debate and marketing their candidates as effectively as the Marlboro Man. For example: Myth: The Republican nominee is an upstanding, regular guy who shares the values of the common man. Reality: He divorced his first wife in order to marry a young multimillionaire heiress whose family then funded his political career. Myth: Republicans are strong on defense and will keep us safe. Reality: They prey on fears, and their endless wars make America far less secure. Myth: Republicans are the party of fiscal restraint and small, limited government. Reality: Soaring deficits, unchecked presidential power, and an increasingly invasive surveillance state are par for their course. The ﬁrst book to dissect the Republican Cult of Personality and leave it openly exposed in its unabashed, shameful depravity, Great American Hypocrites is a deeply necessary call-out to Democrats to attack the GOP with their competitor’s very own weapons. Praise for Great American Hypocrites “Intelligent, insightful.” —Daily Kos “Glenn Greenwald has done it again.” —Alan Colmes “Glenn Greenwald is a treasure.” —BuzzFlash

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306

Publisher

Crown

Published Date

ISBN 10

0307408663

ISBN 13

9780307408662

Book's by Glenn T. Lines

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

Great American Hypocrites

Great American Hypocrites

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