Bioethanol has been considered as a green fuel and a valid alternative to reduce the dependence on fossil distillates. The development of an optimal separation process is considered as a key element in the design of an efficient process able to be cost effective and competitive. Despite many separation techniques are today available, distillation is up to now the frontrunner technology in most of the plants. In particular extractive distillation is considered as an energy efficient method to produce pure ethanol overcoming the purity limitations imposed by the water-ethanol azeotrope. The subspace of simple distillation configurations was generated considering the possibility to employ partial or total condensers to transfer the non-product mixtures between the columns, moreover different numbers of columns are considered. Once the most promising sequences are obtained, the complex columns are investigated. The complex column subspace is generated introducing one or more thermal couplings and considering the possibility to intensify the process combining the column sections performing the same separation task. All the configurations considered, simulated by means of Aspen Plus V 7.3, are compared considering the total condenser and reboiler duty as energy index. The capital costs and the solvent consumption are also taken into account in the final selection. Among all the complex configurations considered the two-column sequence can reduce the capital cost above 10% compared to the best simple column sequence. The performances for different solvents are also taken into account in the process alternatives comparison.
The Physiology and Pathology of the Cerebellum was first published in 1958. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions. The development of electrical methods of recording activity in the nervous system has greatly augmented our knowledge of cerebellar physiology. Now, for the first time in a single volume, this new information has been related to facts derived from older methods of investigation. Previously unpublished reports of experiments conducted at the Institute of Physiology, University of Pisa, Italy, also are included. The authors, an American clinical neurologist and an Italian neuro-physiologist, have collaborated to provide a comprehensive review of cerebellar physiology and a survey of the clinical symptomatology of cerebellar disorders and the pathology of the cerebellum. In Part I, devoted to the physiology, the authors review the literature completely and place it in proper relation to the latest developments in this field. There are chapters on this history of cerebellar physiology, ablation experiments, stimulation experiments, electro-physiological experiments, the relations between the cerebellum and other central nervous structures, developmental physiology, and the functions of the cerebellum, considered generally. Part II is devoted to the human cerebellum as studied in the clinic. Where anatomical and physiological observation may shed light upon obscure clinical findings, the laboratory data are related to the clinical investigations. The disorders and diseases affecting the cerebellum are systemically reviewed. The book is illustrated with 61 halftones and 124 line drawings.
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