Read this book and the world's most famous image will never look the same again. For the world's greatest cultural icon still has secrets to reveal - not the silly secrets that the 'Leonardo loonies' continue to advance, but previously unknown facts about the lives of Leonardo, his father, Lisa Gherardini, the subject of the portrait, and her husband Francesco del Giocondo. From this factual beginning we see how the painting metamorphosed into a 'universal picture' that became the prime vehicle for Leonardo's prodigious knowledge of the human and natural worlds. We learn about the new money of the ambitious merchant who married into the old gentry of Lisa's family. We discover Lisa's life as a wife and mother, her association with sexual scandals, and her later life in a convent. We meet, for the first time, previously undiscovered members of Leonardo's immediate family and discover new information about his early life. The tiny hill town of Vinci is placed before us, with its widespread poverty. We find out about the career and possessions of his father, a notable lawyer in Florence. The meaning of the portrait that resulted from these human circumstances is vividly illuminated though Renaissance love poetry and verses specifically dedicated to Leonardo. We come to understand how Leonardo's sciences of optics, psychology, anatomy and geology are embraced in his poetic science of art. Recent scientific examinations of the painting disclose how it evolved to assume its present appearance in Leonardo's experimental hands. Above all, we cut through the suppositions and the myths to show that the portrait is a product of real people in a real place at a real time. This is the book that brings back a sense of reality into the creation of the portrait of Lisa del Giocondo. And the actual Mona Lisa, it turns out, is even more astonishing and transcendent than the Mona Lisa of legend.
This book offers a comprehensive review of innovative measurement and monitoring solutions based on time domain reflectometry (TDR). This technique has numerous applications in several fields, ranging from the characterization of electronic devices to quality control of vegetable oils. However, most of the well-established TDR-based monitoring solutions rely on local or punctual probes; therefore, typically, to monitor large areas/volumes, a high number of probes must be employed, with the consequent maintenance and management requirements. On such bases, in the last few years, the authors have carried out extensive research on the use of diffused wire-like sensing elements to be used as probes for TDR measurements. The basic idea has been to extend the principles of punctual TDR-based monitoring to multi-purpose networks of diffused, sensing elements (SE's), embedded permanently within the systems to be monitored (STBM's). These SEs can be tens of meters long, and can follow any desired path inside the STBM.; in fact, they are inactive inside the STBM. Additionally, these SE's are passive (i.e., they do not require batteries) and their sensing ability is activated, by the TDR signal, when they are connected to the measurement instrument. In addition to this, these SE's are completely maintenance-free. Starting from these considerations, this book addresses the use of low-cost, passive, flexible, wire-like SE's to be used in conjunction with TDR. This book also provides several application test cases, with hints for practical implementation of the described monitoring systems.
Spatial Microeconometrics introduces the reader to the basic concepts of spatial statistics, spatial econometrics and the spatial behavior of economic agents at the microeconomic level. Incorporating useful examples and presenting real data and datasets on real firms, the book takes the reader through the key topics in a systematic way. The book outlines the specificities of data that represent a set of interacting individuals with respect to traditional econometrics that treat their locational choices as exogenous and their economic behavior as independent. In particular, the authors address the consequences of neglecting such important sources of information on statistical inference and how to improve the model predictive performances. The book presents the theory, clarifies the concepts and instructs the readers on how to perform their own analyses, describing in detail the codes which are necessary when using the statistical language R. The book is written by leading figures in the field and is completely up to date with the very latest research. It will be invaluable for graduate students and researchers in economic geography, regional science, spatial econometrics, spatial statistics and urban economics.
This book revolves around the concept of financial risk tolerance and its role in financial markets. Bridging different literatures and reviewing in detail the impact of European regulation on the evolution of risk tolerance assessment, this book discusses the intersection of scholarly research, practitioner experience and current and likely normative developments. In particular, the book focuses on the evolution of the debate on the suitability questionnaire – a key tool introduced with the Markets in Financial Instruments Directive (MiFID) and further developed with MiFID’s successor - comparing it with empirical evidence on financial risk tolerance determinants, spanning from sociodemographic to behavioral components and life events. The book also looks at the future evolution of the normative framework post MiFID2 addressing in detail two key trends that are already affecting the way in which risk tolerance is dealt with in European financial markets – sustainable development and fintech and roboadvisory. The book includes an original survey run with financial market experts to assess the perceptions regarding these two trends and includes commentaries by a professional financial advisor on the key topics discussed.
Legends of the Sibilline Mountains" is a small book about an obscure corner of Italy and an equally obscure backwater of world literature. And yet the subjects it touches upon--amongst them, the roots of literature in popular consciousness, the intimations of Christian existentialism, the absorption of pagan traditions into Christianity--reach far and wide. Goddess worship, necromantic rites, the death of Pontius Pilate, Benevenuto Cellini, Goethe's "Faust," Wagner's "Tannhauser"...they all connect here in a real place of strange geological formations and magical beauty. The Sibilline Mountains, dividing Le Marche from Umbria, were "celebrated in the 14th and 15th centuries throughout all Europe for magical fairy tales and necromantic initiations," according to the author, Giuseppe Santarelli. In the most famous of these tales a mysterious Sibyl inhabits a grotto devoted to the pleasures of the flesh, luring knights to eternal damnation. Another legend concerns the Lago di Pilato, a mountaintop lake where Pontius Pilate's body had been cast that later became a destination for demonic rituals. In a witty and personal tone Santarelli, director of the Sanctuary of Loreto, discusses the origins of the myths in folklore, their literary transformations through the centuries, and the archeological traces they left behind.
This issue of Cardiac Electrophysiology Clinics--edited by Drs. Luigi Padeletti and Giuseppe Bagliani--will focus on Clinical Arrhythmias: Bradicardias, Complex Tachycardias and Particular Situations. Topics include Introduction to Bradicardias; Sick sinus syndrome; AV nodal conduction disease; Intraventricular delay and Blocks; How to interpret pacemaker, AICD and CRT electrocardiograms; Ectopic beats; Advanced ep mechanisms in the electrogenesis of re-entry svt; Atrial fibrillation and ablation: ecg in the pre and post procedure; Ventricular tachycardias: detailed electrocardiographic aspects; Ventricular Tachicardia Ablation: the role of the Electrocardiogram; J Syndromes; Congenital and acquired long QT syndromes; Clinical approach to the patient with Syncope; Clinical approach to the patient with palpitations; Neonatal and Pediatric Arrhythmias; and Imaging in patients with cardiac arrhythmias.
Morphology of Blood Disorders, 2nd edition is an outstanding atlas with over 800 high-quality digital images, covering the whole spectrum of blood and bone marrow morphology, with particular emphasis on malignant haematology. Originally written in the Italian language by two world leaders in the field, the book has been expertly translated by the renowned haematologist and teacher, Barbara Bain. This book explores the major topics of haematological pathology, blending classical teaching with up-to-date WHO classification and terminology. Each image in this book is derived from material obtained for diagnostic purposes from patients with serious haematological conditions. Morphological details are supplemented by detailed descriptions of the output and role of automated instruments in disorders of the blood. Morphology of Blood Disorders, 2nd edition is an essential reference source for diagnosis in the haematology laboratory, designed to be the go-to guide for anyone with an interest in blood cell morphology.
This book moves from a thorough investigation of human capabilities during movements and interactions with objects and environment and translates those principles into the design planning and control of innovative mechatronic systems, providing significant advancements in the fields of human–robot interaction, autonomous robots, prosthetics and assistive devices. The work presented in this monograph is characterized by a significant paradigmatic shift with respect to typical approaches, as it always place the human at the center of the technology developed, and the human represents the starting point and the actual beneficiary of the developed solutions. The content of this book is targeted to robotics and neuroscience enthusiasts, researchers and makers, students and simple lovers of the matter.
Survival of patients with metastatic cancer has increased over the past two decades as a result of a progressive improvement of regional and systemic therapies. However, oncologists' estimates of patients' predicted overall survival in metastatic cancer are imprecise. The purpose of this book is to systematize the evidence regarding the prognostic factors of metastatic gastrointestinal tumors, separating the findings with the highest level of evidence among those available for each disease by selecting studies with the highest scientific evidence level.
Building on their long-lasting scientific partnership, Civitarese and Ferro offer an array of thought-provoking writings bolstered by extensive clinical material, attesting to their shared interpretation of psychoanalysis not only as a treatment for psychic suffering but also as inherently pleasurable and vitalizing. In chapters that reflect inclinations, fantasies and obsessions that are both shared and personal, and by engaging with topics various enough to include dreams, ethics, emotions and aesthetics, the authors demonstrate how the practice of psychoanalysis might no longer be an insidiously moralistic or ideological exercise but rather a practice aimed at opening up and liberating the mind. By providing detailed engagement with the work of Bion and Ogden, as well as insights from their own substantial expertise, the authors explore how the synonymous concepts of playing and vitality can meaningfully inform and change clinical psychoanalytic practice. With rich clinical material and a strong foundation in established theory, this book will appeal to psychoanalysts, psychoanalytic therapists and postgraduate students hoping to make more room in the psychoanalytic lexicon for words like pleasure, dreaming, creativity, hospitality and growth.
This study presents a new regional history of the middle Tiber valley as a lens through which to view the emergence and transformation of the city of Rome from 1000 BC to AD 1000. Setting the ancient city within the context of its immediate territory, the authors reveal the diverse and enduring links between the metropolis and its hinterland.
Defined as red blood cell break down and the release of hemoglobin and intracellular contents into the plasma, hemolysis can seriously impact patient care as well as the laboratory's reputation through its affect on test results. Therefore, the European Preanalytical Scientific Committee, in collaboration with the International Federation of Clinical Chemistry Working Group on Patient Safety, have designed a questionnaire to collect data on prevalence and management of hemolytic specimens referred to the clinical laboratories for clinical chemistry testing. This book will help identify the areas where hemolysis occurs most frequently, which can, in turn, guide further analysis about why it is occurring. Once these elements are known, practices and procedures can be implemented to dramatically reduce hemolysis and avoid erroneous laboratory results affecting patient care and increasing laboratory costs.
The ESC Textbook of Heart Failure is the latest addition to the European Society of Cardiology (ESC) publications portfolio and is fully supported by the European Heart Failure Association. The textbook brings together internationally renowned experts in the field of heart failure to present an up-to-date understanding of all aspects of this chronic condition that worsens with time. It is estimated that the worldwide population of patients suffering from heart failure is approximately 26 million. This clinically oriented work reflects contemporary European guidelines from the ESC and the European Heart Failure Association and summarizes the latest evidence from clinical trials. Made up of eighteen different sections the textbook covers the epidemiology, etiology, prevention, pathophysiology, and clinical phenotypes of heart failure. The assessment and management of chronic, acute, and advance heart failure are all discussed in detail. As well as chapters dedicated to self-care and patient education, the multidisciplinary approach to heart failure management, and clinical trial design and interpretation. The future direction of the field is discussed throughout with separate chapters on digital health, big data, and telemedicine/remote monitoring in heart failure also included. A must read for cardiovascular healthcare specialists in Europe and across the world it should also appeal to those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, and specialist nurses too.
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