This new edition differs from the preceding ones in that there has been extensive revision of most chapters. Recent advances in research gained by immunohistochemical, molecular biological, and cytogenetic methods are included, as far as they are applicable for daily diagnostic work. The chapter on neoplasms, in particular, has been greatly expanded in accordance with the new WHO International Histological Classification of genital tract tumors, covering all pertinent differential diagnostic aspects. The chapter on malignant lymphomas and hematopoetic neoplasms involving the endometrium is a new contribution to this edition (F. D. , Ulm). We have revised the chapter on gestational diseases, incorpor- ing recent advances in the differential diagnosis of gestational trophoblastic tumors. New discoveries and experiences in correlating structure and function in infertility and in h- mone replacement therapy of peri- and postmenopausal patients are also included. Many new microphotographs have been added to illustrate the advances in tumor research and in immunohistochemical detection methods. We have updated the list of references including recent relevant publications. To the correspondents and consultants who have contributed valuable observations and suggestions, bringing thereby to our attention omissions in the second edition, we acknowledge our cordial thanks. We thank Dr. Wolfram Klapper, Director of the L- phom Register of the University of Kiel, for case material for making the micropho- graphic illustrations of lymphomas. The staff of Springer-Verlag has earned our gratitude for their skill in preparing this new edition.
Reevaluation of tumor classification, differential diagnosis and differential therapy based on modern knowledge. Revision of all chapters to incorporate new facts based on recent discoveries.
The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology, tumor virology, and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in op- mizing clinical management and prognosis. A new chapter on immunohistochemistry has been added, which includes refined detection methods, e. g., the overexpression of INK4a p16 as a molecular marker in the early differential diagnosis of premalignant - sions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cel- lar and nuclear deregulation at the molecular level. All chapters have been revised to - clude the newest advances and relevant experiences in how to interpret and manage cervical disease; they are supported by the addition of 35 new microphotographic ill- trations. The tumor nomenclature is adapted to the latest edition of the WHO classi- cation; the morphology code of the international classification of diseases for oncology (ICD-O) has been added. We have also updated the list of references by adding recent relevant publications. Again, the staff of Springer-Verlag deserve our thanks for their patience and skill in preparing the manuscript and in reproducing the microphotographs. Heidelberg, February 2005 Gisela Dallenbach-Hellweg, Magnus von Knebel Doeberitz, and Marcus J. Trunk Heading2 Preface to the First Edition During the past decade our understanding of the histopathology of the cervix uteri has changed greatly.
Der Atlas gibt einen umfassenden Überblick über den diagnostischen Aussagewert der Phasenkontrastmikroskopie für die gynäkologische Sprechstundenzytologie am Frischpräparat. Nach einer Einführung in die Anwendungsbereiche der gynäkologischen Vitalzytologie verhelfen technische Erläuterungen zur präzisen Handhabung der Methode und des Phasenkontrastmikroskops. Der anschlie€ende Textteil vermittelt eine straff gegliederte Zusammenfassung der wesentlichen Erkennungsmerkmale der Einzelzellen und des Gesamtzellbildes unter physiologischer hormoneller Stimulation und deren endogen oder iatrogen ausgelösten Abweichungen, unter bakterieller Besiedelung und im Laufe der Karzinogenese. Es folgen Beschreibungen von Nebenbefunden, sekundären Zellveränderungen und Artefakten. In gleicher Reihenfolge sind im angeschlossenen Bildteil 143 meist gro€formatige Mikroskopaufnahmen typischer Zellen und Zellverbände dargestellt. This atlas provides a comprehensive overview of the diagnostic value of phase-contrast microscopy in the cytologic examination of smears taken in the gynecological practice. The range of applications and methods are fully described. The text summarizes distinguishing factors of single cell and the overall clinical picture. The atlas section contains large-format photomicrographs of cells and cell clusters.
An atlas covering the normal and pathologic histology of the uterine cervix. Differential diagnosis is given in detail yet related to clinical aspects, so that a functional de- scription of benefit in daily practice is achieved.
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