ROG. Of course he's nuts, but just how dangerous is he? ABEL. He just wants to know one thing: when does friendship end and kidnapping begin? DAN. Fun is fun, but is he the only one who has noticed that everything is getting out of hand? JOHNNY. The dreams come frequently, but what do they mean and why can he get the blood off of his hands? THE DEATH VALLEY KIDS. THEY'RE ALL GROWN UP WITH NOTHING TO DO…
Overgrowth Syndromes is a comprehensive clinical guide to the well-defined genetic disorders (and others that are less well-defined) for which somatic overgrowth is a major manifestation. It details the unique characteristics and known causative genes for this class of disorders, offering clinicians an expert resource for both clinical diagnosis and laboratory confirmation. Assembled by the world's leading experts on overgrowth, this volume maximizes clinical utility without sacrificing nuance or rigor. It codifies the last decade's sweeping advances in understanding general and segmental overgrowth, including the latter's mosaic nature and phenotypic variability. It is an essential resource for clinicians navigating this set of conditions from clinical presentation all the way to counseling and anticipatory management.
The transformation of the dominant model of centralized energy production from fossil fuels to renewable energies is at the center of the public and scientific debate, as well as the subject of national and European policies, as it is connected to highly topical issues such as climate change, emissions reduction and natural disasters, security of supply and sustainability of the current economic development model. Up to now this topic has been mainly addressed by the economic and engineering sciences, with a research focus on the hardware rather than on the human and social software. However, energy systems, and the possibilities of change, are not only economic or technological but involve also patterns of social life, representations, organizational models and relational structures. In order to generate the social preconditions for the transition to a low-emission society, focused on a growing production of energy from renewable sources and on a greater sustainability of consumption, it is therefore urgent to reaffirm the centrality of a sociological approach to energy. This book focused on three core research areas which are crucial to understand what is at stake with the energy transition: conflicts over the construction and location of renewable energy production plants; collective action on renewable sources that promote a new model of energy system in which consumers are also producers; and the social-territorial impact of energy policies.
This issue of Dermatologic Clinics, guest edited by Jane M. Grant-Kels, Giovanni Pellacani, and Caterina Longo, is devoted to Confocal Microscopy. Articles in this timely issue include: Basics of Confocal Microscopy and the Complexity of Diagnosing Skin Tumors: New Imaging Tools in Clinical Practice, Diagnostic Workflows, Cost-estimate and New Trends; Opening a Window Into Living Tissue: Histopathologic Features of Confocal Microscopic Findings in Skin Tumors; Addressing the Issue of Discriminating Nevi from Early Melanomas: Dues and Pitfalls; Melanoma Types and Melanoma Progression: The Different Faces; Lentigo Maligna, Macules of the Face and Lesions on Sun-damaged Skin: Confocal makes the Difference; Glowing in the dark: use of confocal microscopy in dark pigmented lesions; Enlightening the Pink: Use of Confocal Microscopy in Pink Lesions; Shining into the White: The Spectrum of Epithelial Tumors from Actinic Keratosis to SCC; Application of Wide-probe and Handy-probe for Skin Cancer Diagnosis: Pros and Cons; Confocal Microscopy for Special Sites and Special Uses; Confocal Algorithms for Inflammatory Skin Diseases and Hair Diseases; In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs’ Surgeons; Telediagnosis with Confocal Microscopy: A Reality or a Dream?; “Well-aging": Early Detection of Skin Aging Signs; The Role of Confocal Microscopy in Clinical Trials for Treatment Monitoring; and Fluorescence (multiwave) Confocal Microscopy.
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