This book carries out a comprehensive analysis of the María Luz incident, a truly significant episode in Japanese and world history, from a legal perspective. In July 1872, the María Luz, a barque flying the Peruvian flag, carried Chinese indentured servants from Macau to Peru. After the ship stopped for repairs in Kanagawa Bay, a number of legal issues arose that were destined to change the perception and use of the law in Japan forever. The case had a tremendous impact on the collective imagination, both Japanese and international: it is one of the first occurrences in which an Asian country decided to resist the pressure of a Western nation, and responded using the most refined tools of domestic and international law. Moreover, the final outcome of the case (arbitration in front of the Czar of Russia) marks the debut of Japan on the stage of international arbitration. While historians have written widely on the subject, the legal importance of this event has been relatively neglected. This book uses the case to explore the technical legal issues Japan was facing in its transition from pre-modernity to modernity. These include unequal treaties, extraterritoriality clauses, the need to establish an updated judicial system, and a delicate balance between asserting sovereignty and resorting to diplomacy in solving disputes involving foreigners. Based on original documents, this book is an invaluable resource for researchers and academics in the fields of legal history, dispute resolution, international law, Japanese history and Asian studies.
Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects translating molecular mechanisms into clinical trials structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.
This book combines concise descriptions of the various andrological surgical interventions in the adolescent and adult with detailed analysis of the pre- and postoperative psychosexual counseling of the patient and his family that is appropriate to each procedure. It offers a multidisciplinary approach to the candidate for andrological surgery that reflects the everyday experiences of an andro-sexology team. Each chapter focuses on a particular surgical procedure. Succinct description of the disease and its epidemiology, diagnosis, and treatment is followed by extensive discussion of all aspects of psychosexual relevance and the required counseling. Topics addressed include, for example, the impact of diagnosis, body image issues, fears relating to the surgical procedure and its outcome, the risk of excessive expectations and consequent disillusionment, relationship issues and communication problems, and the role of the sexologist. The analysis and guidance offered in this book will be of particular value to the less experienced andrologist and will assist in achieving postoperative patient satisfaction.
Il CIRS – Centro Internazionale per la Ricerca Sociale nella scienza della salute presenta un nuovo volume sulle fondazioni italiane che si occupano di sanità: un’opera particolarmente innovativa, non trovandosi nulla di simile nel paesaggio scientifico italiano. Il libro contiene una prefazione del Magnifico Rettore dell’Università UniCamillus di Roma, Gianni Profita, una postfazione del Presidente dell’Ordine dei Medici di Roma, Antonio Magi, e risulta arricchita da un saggio critico del professor Ugo Giorgio Pacifici Noja. Per ogni fondazione sono indicati elementi quali l’anno di fondazione, i fondatori, la mission, gli organi istituzionali e il partenariato. Sono presenti l’indice analitico, dei nomi, delle fondazioni, dei luoghi e un siglario diretto a decriptare acronimi spesso misteriosi.
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