Gideon P. Smith's Books

Animal Models for the Study of Human Disease

Chapter 19. Animal Models of Fibrosis in Human Disease

By: Gideon P. Smith

Write a review Read reviews Take a Quiz Solve Book Puzzle

Animal Models for the Study of Human Disease

Chapter 19. Animal Models of Fibrosis in Human Disease

By: Gideon P. Smith

Although fibrosis can occur as part of normal wound healing, dysregulated fibrosis can affect almost any organ and results in severe dysfunction. Despite the variety of human disease of which this is a feature these diseases remain poorly understood due in part to the slow largely asymptomatic onset. Animal models are our only means to examine the early stages of these diseases. With them we can isolate perturbations in signaling pathways, chemokines and cytokines and study their effects. Here we summarize animal models that have been developed for the study of the most common human fibrotic conditions. We separate models of scleroderma and cirrhosis as the model development for each of these conditions face unique challenges. Although still imperfect, elegant solutions have been developed for modeling fibrosis in each. Indeed, progress in this area is currently rapid, and animal models will likely remain critical in moving forward our scientific understanding of these disease states.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

Publisher

Elsevier Inc. Chapters

Published Date

ISBN 10

0128072091

ISBN 13

9780128072097

Neonatal and Pediatric Clinical Pharmacology, An Issue of Pediatric Clinics

By: John N van den Anker,Max J. Coppes,Gideon Koren

Write a review Read reviews Take a Quiz Solve Book Puzzle

Neonatal and Pediatric Clinical Pharmacology, An Issue of Pediatric Clinics

By: John N van den Anker,Max J. Coppes,Gideon Koren

The need for safe and effective use of medicines in children and WHO's initiative "Make Medicines Child Size" have boosted research and educational activities in the area of pediatric clinical drug research. This issue focuses on both general and specific aspects of neonatal and pediatric clinical pharmacology including ethics, pharmacogenomics, metabolomics, adverse drug reactions, pain medication, pulmonary hypertension and several other hot topics. The editors have been able to find outstanding authors for the different parts on neonatal and pediatric pharmacology.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

255

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

1455747386

ISBN 13

9781455747382

Killer Lymphocytes

By: Gideon Berke,William R. Clark

Write a review Read reviews Take a Quiz Solve Book Puzzle

Killer Lymphocytes

By: Gideon Berke,William R. Clark

This extensively documented, comprehensive survey of cell-mediated cytotoxicity (CMC) traces the history of killer lymphocytes from 1960 to the present, providing a definitive resource for specialists and non-specialists alike. It offers an advanced analysis of CMC, including a comprehensive examination of key papers underlying its evolution, and provides a thorough discussion of the most recent advances in the field.

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

361

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1402032706

ISBN 13

9781402032707

Book's by Gideon P. Smith

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease

Neonatal and Pediatric Clinical Pharmacology, An Issue of Pediatric Clinics

Neonatal and Pediatric Clinical Pharmacology, An Issue of Pediatric Clinics

Killer Lymphocytes

Killer Lymphocytes

Username

Password

Username

Password

Password again

Birthday

Email