Presents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis. Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design - The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation; ; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis. -Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production -Focuses on the application of catalytic methods for the synthesis of known APIs -Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more -Includes recent patent literature for completeness Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.
The influence of Cicero is everywhere to be found. His rhetorical and philosophical writings have made an inescapable impact on the history of western culture, impressing figures such as Augustine, Jerome, Petrarch, Erasmus, Martin Luther, John Locke, David Hume, John Adams and Thomas Jefferson. Despite his wide appeal, until now no study has yet offered a comprehensive overview of 'Cicero' as a character in stage plays in the early modern and modern periods. The first book of its kind to discuss Cicero's reception on stage, it includes works by Ben Jonson (1611, Catiline His Conspiracy), Voltaire (1752, Rome sauvée, ou Catilina), Richard Cumberland (1761, The Banishment of Cicero), Henry Bliss (1847, Cicero, A drama) and, most recently, Mike Poulton (Imperium, adapted from the novels of Robert Harris in 2017). Through a chapter-by-chapter account of each play in turn, every oeuvre is placed in its historical and cultural context; the plots are discussed in relation to the ancient sources. These analyses demonstrate how the presentation and assessment of the figure of Cicero develop over time and how this character is exploited for varying political statements. The wealth of material in this book is vital reading for scholars of Classics, drama and literary studies as well as historians of ideas and of the early modern age.
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