This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV. Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients. In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices.
This radical, provocative and inspiring book explores a tectonicshift at the very heart of business. A shift that?s making the oldbottom line of corporate profitability the servant of a new master:a new ?person-centric? bottom line of personal profitability orvalue ?in my life?. So what? No bottom line? No more profit? Of course not! Every organization must cover its costs. Everybusiness has to make a profit to survive. The authors of The NewGlobal Line remarkably show that the necessary requirements fordoing so are changing, and why this transformation ? containingimportant elements of both evolution and revolution ? is under way,how it?s undermining the foundations of once-great businesses andbrands, and how its throwing up huge new opportunities.
Each release of DFSMS builds upon the previous version to provide enhanced storage management, data access, device support, program management, and distributed data access for the z/OS® platform in a system-managed storage environment. This IBM® Redbooks® publication provides a summary of the functions and enhancements in z/OS V1R12 DFSMS. It provides you with the information that you need to understand and evaluate the content of this DFSMS release, along with practical implementation hints and tips. Also included are enhancements that were made available through enabling PTFs that have been integrated into z/OS V1R12 DFSMS. This book was written for storage professionals and system programmers who have experience with the components of DFSMS. It provides sufficient information so that you can start prioritizing the implementation of new functions and evaluating their applicability in your DFSMS environment.
With the advice here on everything from tactics for different positions to motivation, you can create a successful training program for yourself or your team that's sure to give you a winning edge on the field.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.