PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.
The maturing of the baby boomers has heralded the age of the bionic man, who is literally composed of various replacement organs or biomechanical parts. This book provides a comprehensive and up-to-date scientific source of biomedical engineering principles of ?replacement parts and assist devices? for the bionic man. It contains topics ranging from biomechanical, biochemical, rehabilitation, and tissue engineering principles, to applications in cardiovascular, visual, auditory, and neurological systems, as well as recent advances in transplant, gene therapy, and stem cell research.
Entrepreneurship is changing. Technology and social networks create a smaller world, but widen the opportunity horizon. Today's entrepreneurs build organisations and create value in entirely new ways and with entirely new tools. Rather than just exploit new ideas, innovative entrepreneurs design organisations to make sense of unlikely opportunities. The time has come to overhaul what we know about entrepreneurship and business models. Models of Opportunity links scholarly research on business models and organisational design to the reality of building entrepreneurial firms. It provides actionable advice based on a deeper understanding of how business models function and change. The six insights extend corporate strategy and entrepreneurship in a completely new direction. Case studies of innovative companies across industries demonstrate how visionary entrepreneurs achieve unexpected results. The insights, tools and cases, provide a fresh perspective on emerging trends in entrepreneurship, organisational change and high-growth firms.
Ophthalmic Surgery, edited by Drs. George Spaeth, Helen Danesh-Meyer, Ivan Goldberg, and Anselm Kampik, provides the detailed, full-color, step-by-step guidance you need to master essential ophthalmic surgery procedures. The international team of expert editors and contributors present coverage of the latest surgical developments and video demonstrations of key techniques across subspecialties, including cataract, cornea, refractive, glaucoma, oculoplastic, extra-ocular muscle, vitreoretinal, and ocular tumor procedures. What’s more, the fully searchable text, procedural videos, and a downloadable image gallery are all online at www.expertconsult.com, making this multimedia resource the key to performing confidently in the operating room. Refer to the most important steps in each procedure quickly and easily with an appendix of step-by-step hand notes. Perform a wide variety of procedures with confidence using the focused coverage that pinpoints essential information and avoids extraneous details. Get comprehensive coverage across key subspecialties—oculoplastic, strabismus, cornea, refractive, cataract, glaucoma, ocular tumors, and vitreoretinal—and master the basics for every common procedure. Access the fully searchable contents online at www.expertconsult.com, along with procedural videos and a downloadable image gallery. Apply the latest advances in laser surgery that have become standard practice with the new section on refractive surgery. Master key techniques thanks to more than four hours of narrated online videos that demonstrate procedures across eight subspecialties. Gain a more nuanced visual understanding through a new full-color art program with over 800 illustrations, updated and revised drawings, color images, and step-by-step illustrated procedures. Tap into the expertise of leading authorities in the field with a brand new editorial team from North America, Europe, and Australasia, as well as international contributors who provide global perspectives across all subspecialties in ophthalmic surgery.
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