“As different artists sculpt different statues from the same block of marble, different environments produce different characters, even in identical twins.” Evelyn, a geneticist and amateur archeologist, makes a formidable discovery in Israel, the consequence of which is the birth of Christopher and José, identical twins raised apart, one in affluent Sydney, the other in the slums of Buenos Aires. The twins, unaware of each other’s existence or their origin, will meet for a moment only, in the Amazon, adversaries in the battle for the forest. Standing by both twins is Lorena, a medical student who under the claws of a dictatorship organizes the student environmental resistance. A novel whose heroes travel to four continents in search of their identity. How can values such as love, faith, forgiveness and freedom change their lives? What are the limits of science and the brain? Can there be consilience between humans and nature?
The Rat Brain in Stereotaxic Coordinates, Second Edition is an atlas of the rat brain based on the convenient flat-skull position that is sufficiently comprehensive and stereotaxically accurate for adult rats. The rat brain is analyzed through stereotaxic localization of discrete brain areas and the subdivisions of many areas of rat brain are mapped using plates and diagrams. Photographs of sufficient magnification are included to permit investigators to judge for themselves the veracity of the atlas delineations. This atlas is based on the study of 130 adult male Wistar rats (with a weight range of 270-310 g). It is suitable for brains of 250-350 g male and female rats and represents all areas of the brain and spinal cord. Brain areas are shown in coronal, sagittal, and horizontal planes. The brain sections shown were taken on average at 0.25 mm intervals and were stained with either cresyl violet or for the demonstration of acetylcholinesterase (AChE). The atlas is based on fresh brains frozen in the skull (using deeply anesthetized rats) in order to overcome distortion produced by fixation and to enhance staining contrast. Structures are delineated on the basis of data on cytoarchitecture, chemoarchitecture, and connectivity. The procedures used for surgery, histology, and photography are also explained. This atlas is intended for use by researchers and graduate students in the neuroscience, as well as senior undergraduates interested in brain anatomy and function.
Work on the human brainstem has been impeded by the unavailability of a comprehensive diagrammatic and photographic atlas. In the authors' preliminary work on the morphology of the human brainstem (The Human Nervous System, 1990), Paxinos et al demonstrated that it is possible to use chemoarchitecture to establish a number of human homologs in structures known to exist in the rat, the most extensively studied species. Now, with the first detailed atlas on the human brainstem in more than forty years, the authors present an accurate, comprehensive, and convenient reference for students, researchers, and pathologists. Key Features * The first detailed atlas on the human brainstem in more than forty years * Delineated as accurately as The Rat Brain in Stereotaxic Coordinates, Second Edition (Paxinos/Watson, 1986), the most cited book in neuroscience * Based on a single brain from a 59-year-old male with no medical history of neurological or psychiatric illness * Represents all areas of the medulla, pons, and midbrain in the plane transverse to the longitudinal axis of the brainstem * Consists of 64 plates and 64 accompanying diagrams with an interplate distance of half a millimeter * The photographs are of Nissl and acetylcholinesterase (AChE) stained sections at alternate levels * Establishes systematically the human homologs to nuclei identified in the brainstem of the rat Reviewed by leading neuroanatomists * An accurate and convenient guide for students, researchers, and pathologists
Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates, Compact Fifth Edition, is the compact version of the most widely used and cited atlas of the mouse brain in print. It emulates in design and accuracy Paxinos and Watson’s The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. The compact edition provides the coronal plates and diagrams of the full mouse atlas in a smaller, more convenient spiral format and at a student friendly price. High resolution digital photographs of the coronal plane of section from the full 5th edition complement the coronal drawings. Unique to the compact, it includes an introduction to the use of the atlas in stereotaxic surgery. Contains 100 coronal diagrams that were fully revised for this new edition Includes 100 coronal photographic plates produced from directly scanned, very high-resolution images of the biological sections (done at the Allen Institute) Provides a beginner's guide with 25 pages on conducting stereotaxic surgery and how to use the atlas Presents surface views of the brain with labels over the major structures Uses the best ontology tree (nomenclature based on the development of the brain) with universal applications across mammals
Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates, Fifth Edition, emulates in design and accuracy Paxinos and Watson's The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. - 100 thoroughly revised coronal diagrams and accompanying photographic plates spaced at approximately 120 μm intervals - 32 thoroughly revised sagittal diagrams and accompanying photographic plates - 30 thoroughly revised horizontal diagrams and accompanying photographic plates - Photographic plates printed from high resolution digital images in color - The most accurate and virtually universally used stereotaxic coordinate system - Over 800 structures identified - Includes the Expert Consult eBook version, compatible with PC, Mac, and most mobile devices and eReaders, which allows readers to browse, search, and interact with content
This atlas provides an accurate and detailed depiction of all brain structures at fetal stage E17.5, Day of birth, and Day 6 postnatal. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs. It is an indispensable guide for the interpretation of nervous system changes in gene knockout and transgenic mice. Contains: 43 photographs and drawings of Nissl-stained coronal sections of the brain of a fetal mouse at E17.5 days, 65 photographs and drawings of Nissl-stained coronal sections of the brain of a mouse on the day of birth, and 73 photographs and drawings of Nissl-stained coronal sections of the brain of a mouse aged 6 days postnatal. The drawings are based on the study of sections stained with Nissl and a range of neuroactive substances. In addition to brain structures, the atlas delineates peripheral nerves, ganglia, arteries, veins, muscles bones and other organs.
The preceding editions made The Rat Brain in Stereotaxic Coordinates the second most cited book in science. This Fifth Edition is the result of years of research providing the user with the drawings of the completely new set of coronal sections, now from one rat, and with significantly improved resolution by adding a third additional section level as compared to earlier editions. Numerous new nuclei and structures also have been identified. The drawings are presented in two color, providing a much better contrast for use. The Fifth Edition continues the legacy of this major neuroscience publication and is a guide for all students and scientists who study the rat brain. - 161 coronal diagrams based on a single brain. - Delineations drawn entirely new from a new set of sections. - Diagrams spaced at constant 120 μm intervals resulting in the high resolution and convenience of use. - Drawings use blue color lines and black labels to facilitate extraction of information. - The stereotaxic grid was derived using the same techniques that produced the widely praised stereotaxic grid of the previous editions. - Over 1000 structures identified, a number for the first time in this edition.
The fourth edition of Atlas of the Human Brain presents the anatomy of the brain at macroscopic and microscopic levels, featuring different aspects of brain morphology and topography. This greatly enlarged new edition provides the most detailed and accurate delineations of brain structure available. It includes features which assist in the new fields of neuroscience – functional imaging, resting state imaging and tractography. Atlas of the Human Brain is an essential guide to those working with human brain imaging or attempting to relate their observations on experimental animals to humans. Totally new in this edition is the inclusion of Nissl plates with delineation of cortical areas (Brodmann's areas), the first time that these areas have been presented in serial histological sections. - Winner of the 2016 British Medical Association Award for Best Illustrated Text and previous edition winner of the Award of Excellence from the American Association of Publishers - The contents of the Atlas of the brain in MNI stereotaxic space has been extensively expanded from 143 pages, showing 69 levels through the hemisphere, to 314 pages representing 99 levels - In addition to the fiber-stained (myelin) plates, we now provide fifty new (Nissl) plates covering cytoarchitecture. These are interdigitated within the existing myelin plates of the stereotaxic atlas - All photographic plates now represent the complete hemisphere - All photographs of the cell- and fiber-stained sections have been transformed to fit the MNI-space - Major fiber tracts are identified in the fiber-stained sections - In the Nissl plates cortical delineations (Brodmann's areas) are provided for the first time - The number of diagrams increased to 99. They were now generated from the 3D reconstruction of the hemisphere registered to the MNI- stereotaxic space. They can be used for immediate comparison between our atlas and experimental and clinical imaging results - Parts of cortical areas are displayed at high magnification on the facing page of full page Nissl sections. Images selected highlight those areas which are thought to correspond with those published by von Economo and Koskinas (1925) - A novel way of depicting cortical areal pattern is used: The cortical cytoarchitectonic ribbon is unfolded and presented linearly. This linear representation of the cortex enables the comparison of different interpretations of cortecal areas and allows mapping of activation sites - Low magnification diagrams in the horizontal (axial) and sagittal planes are included, calculated from the 3D model of the atlas brain
**Selected for Doody's Core Titles® 2024 in Neuroscience** MRI/DTI Atlas of the Human Brainstem in Transverse and Sagittal Planes presents a detailed view of the human brainstem in DTI/MRI. It is the first ever MRI or histological atlas to present detailed diagrams of sagittal views of the brainstem. Presenting data of unprecedented quality, images are juxtaposed with detailed diagrams in the transverse and sagittal planes. The atlas features a 50 micron resolution for the GRE and 200 microns for the FAC and DWI, 8000 times higher than that seen in a clinical MRI and 1000 times higher than that seen in a clinical DTI scan, all based on one brain. This atlas is important for neuroscientists, neurosurgeons, pathologists, anatomists, neurophysiologists, radiologists, radiotherapists (e.g., for cyberknife guidance), and graduate students in neuroscience. - Presents the first ever detailed MRI-DTI atlas on the human brainstem - Discusses primary data to help researchers identify brainstem structures in their own preparations from neuroanatomical, physiological, neuropharmacological and gene expression studies - Accompanies the gold standard reference on the neuroanatomy of the human nervous system for neuroscientists and experimental psychologists - Includes the Expert Consult eBook version that is compatible with PC, Mac and most mobile devices and eReaders, thus allowing readers to browse, search and interact with content
Work on the human brainstem has been impeded by the unavailability of a comprehensive diagrammatic and photographic atlas. In the authors' preliminary work on the morphology of the human brainstem (The Human Nervous System, 1990), Paxinos et al demonstrated that it is possible to use chemoarchitecture to establish a number of human homologs in structures known to exist in the rat, the most extensively studied species. Now, with the first detailed atlas on the human brainstem in more than forty years, the authors present an accurate, comprehensive, and convenient reference for students, researchers, and pathologists. Key Features * The first detailed atlas on the human brainstem in more than forty years * Delineated as accurately as The Rat Brain in Stereotaxic Coordinates, Second Edition (Paxinos/Watson, 1986), the most cited book in neuroscience * Based on a single brain from a 59-year-old male with no medical history of neurological or psychiatric illness * Represents all areas of the medulla, pons, and midbrain in the plane transverse to the longitudinal axis of the brainstem * Consists of 64 plates and 64 accompanying diagrams with an interplate distance of half a millimeter * The photographs are of Nissl and acetylcholinesterase (AChE) stained sections at alternate levels * Establishes systematically the human homologs to nuclei identified in the brainstem of the rat Reviewed by leading neuroanatomists * An accurate and convenient guide for students, researchers, and pathologists
In response to the explosion of research in developmental neurobiology, this new edition of the Atlas of the Developing Rat Brain has been expanded to include all of the plates and diagrams of the previous book, PLUS an additional 95 plates and 95 diagrams delineating the entire rat nervous system. Atlas of the Developing Rat Nervous System features large, high-magnification photographs of serial brain sections of the embryonic and neonatal laboratory rat, with opposing fully labeled diagrams. Complementing the classic atlas by Paxinos and Watson, The Rat Brain in Stereotaxic Coordinates, Second Edition (Academic Press, 1986), this new atlas is the standard reference for developmental neuroscientists. Key Features * Provides section-by-section photographs and accompanying labeled diagrams of the embryonic and neonatal rat brain * Shows brain development at Embryonic Days 14 (Whole embryo), 16, 17, and 19, as well as Postnatal Day 0 * Delineates nerves, ganglia, arteries, veins, bones, and foramina of the head on Embryonic Days 14 and 19 * Depicts 912 brain structures or their primordial counterparts * Large size in an easy-to-use, spiral-bound format * Includes a full list of abbreviations, index of structures, and references * 224 photographs alongside meticulously drawn diagrams depict the central and peripheral nervous system and other body organs * Depicts ages E14, E16, and E19 in the customary coronal and sagittal planes and E17 and P0 in the coronal plane
In response to the explosion of research in developmental neurobiology, this new edition of the Atlas of the Developing Rat Brain has been expanded to include all of the plates and diagrams of the previous book, PLUS an additional 95 plates and 95 diagrams delineating the entire rat nervous system. Atlas of the Developing Rat Nervous System features large, high-magnification photographs of serial brain sections of the embryonic and neonatal laboratory rat, with opposing fully labeled diagrams. Complementing the classic atlas by Paxinos and Watson, The Rat Brain in Stereotaxic Coordinates, Second Edition (Academic Press, 1986), this new atlas is the standard reference for developmental neuroscientists. Key Features * Provides section-by-section photographs and accompanying labeled diagrams of the embryonic and neonatal rat brain * Shows brain development at Embryonic Days 14 (Whole embryo), 16, 17, and 19, as well as Postnatal Day 0 * Delineates nerves, ganglia, arteries, veins, bones, and foramina of the head on Embryonic Days 14 and 19 * Depicts 912 brain structures or their primordial counterparts * Large size in an easy-to-use, spiral-bound format * Includes a full list of abbreviations, index of structures, and references * 224 photographs alongside meticulously drawn diagrams depict the central and peripheral nervous system and other body organs * Depicts ages E14, E16, and E19 in the customary coronal and sagittal planes and E17 and P0 in the coronal plane
The Rat Brain in Stereotaxic Coordinates provides an atlas of the rat brain. The main features of this atlas are: (1) It is based on the flat-skull position, and bregma, lambda, or the midpoint of the interaural line can be used as a reference point. (2) The atlas is based on the study of 130 adult male Wistar rats (with a weight range of 270-310 g). It is suitable for brains of 250-350 g male rats. (3) It represents all areas of the brain and spinal cord, and brain areas are shown in coronal, sagittal, and horizontal planes. The brain sections shown were taken at 0.5 mm intervals and were stained with either cresyl violet or for the demonstration of acetylcholinesterase (AChE). (4) It is based on fresh brains frozen in the skull (using deeply anaesthetized rats) in order to overcome distortion produced by fixation and to enhance staining contrast. (5) Structures are delineated on the basis of data on cytoarchitecture, connectivity, histochemistry, and development. The book is intended for researchers and graduate students in the neurosciences. Senior undergraduates should also find the atlas a useful adjunct to readings and lectures in brain anatomy and function.
The complement to The Rat Brain in Stereotaxic Coordinates, Chemoarchitectonic Atlas of the Rat Brain, Third Edition, features a single brain series of high-quality plates stained with eight different markers, extensively annotated and labelled throughout. Plates from the previous edition of Chemoarchitectonic Atlas of the Rat Brain have been re-scanned at high resolution and are shown in color. Labeled structures have been revised, corrected, and updated, providing users with a streamlined, up-to-date, and highly accurate compendium of chemical markers. Researchers with a need to understand the detailed organization of the rat brain as well as structure/function relationships will need this atlas and its array of stains. - Provides an archive of chemical markers in the rat brain used in many areas of research - Discusses primary data to help researchers identify structures in their own preparations from neuroanatomical, physiological, neuropharmacological, and gene expression studies - Accompanies the gold standard reference on the neuroanatomy of the nervous system of the most important model animal in neuroscience and experimental psychology - Covers both the rat forebrain and the rat brainstem - Thoroughly revised identification of structures following the new data from The Rat Brain in Stereotaxic Coordinates 7th edition and the Chick Brain in Stereotaxic Coordinates 2nd edition - Includes the Expert Consult eBook version, compatible with PC, Mac, and most mobile devices and eReaders, which allows readers to browse, search, and interact with content
The complement to The Rat Brain in Stereotaxic Coordinates, Chemoarchitectonic Atlas of the Rat Brain, Third Edition, features a single brain series of high-quality plates stained with eight different markers, extensively annotated and labelled throughout. Plates from the previous edition of Chemoarchitectonic Atlas of the Rat Brain have been re-scanned at high resolution and are shown in color. Labeled structures have been revised, corrected, and updated, providing users with a streamlined, up-to-date, and highly accurate compendium of chemical markers. Researchers with a need to understand the detailed organization of the rat brain as well as structure/function relationships will need this atlas and its array of stains. - Provides an archive of chemical markers in the rat brain used in many areas of research - Discusses primary data to help researchers identify structures in their own preparations from neuroanatomical, physiological, neuropharmacological, and gene expression studies - Accompanies the gold standard reference on the neuroanatomy of the nervous system of the most important model animal in neuroscience and experimental psychology - Covers both the rat forebrain and the rat brainstem - Thoroughly revised identification of structures following the new data from The Rat Brain in Stereotaxic Coordinates 7th edition and the Chick Brain in Stereotaxic Coordinates 2nd edition - Includes the Expert Consult eBook version, compatible with PC, Mac, and most mobile devices and eReaders, which allows readers to browse, search, and interact with content
Atlas of the Developing Mouse Brain, Second Edition builds on the features of successful first edition, providing a comprehensive and convenient reference for all areas of the mouse brain at Fetal-Day 17.5 (E17.5), Day-of-Birth (P0), and Day-Six postnatal (P6). The book also delineates the parts of the eye, features of the skull, ganglia, nerves, arteries, veins, bones and foramina. This atlas is an essential tool for researchers and students who study the development of the mouse brain, or for those who interpret findings from genetic manipulation. - Contains 176 high-resolution color scans of Nissl-stained coronal sections of the brain and skull of the fetal (E17.5), day-of-birth (P0), and day-six postnatal mouse (P6) - Includes diagrams that delineate all structures of the brain, as well as peripheral nerves, ganglia, muscles, bones, veins and arteries of the head - Presents approximately 5000 corrections and updates from the first edition - Includes color codes of the veins, arteries, nerves and ganglions of the skull in diagrams
The administration of psychological care to persons with brain disorders requires a series of skills that integrate the knowledge of clinical neuropsychology with developmental psychology, psychotherapy, rehabilitation, and the study of the humanities. In Clinical Neuropsychology and the Psychological Care of Persons with Brain Disorders, Dr. Prigatano describes his approach to this complex topic. He reviews some of the defining characteristics of human nature, and blends that discussion with an understanding of how the brain normally develops and declines with age. The psychological struggles of people at each stage of development are further described as different brain disorders occur at different times in development.
Australian mathematician Christos studies neural networks, memory and learning, and adaptive systems. He presents a theory of how memory is stored, processed, retrieved, and manipulated; proposes ideas of how the brain can generate novel information and creative ideas; contemplates what the brain may be doing during dreaming; and delivers his theory about the cause of sudden infant syndrome. He tries to keep the discussion accessible to general readers, but hopes scientists may also find interest in it.
This reference series will provide all researchers using laboratory animals with comprehensive practical information on the various species. Each title in the series is devoted to a particular species, and draws together all available data in a "one-stop", easily accessible source. Each has similar format, with sections on the strains available, their husbandry, and special diets. Also included are sections on gross anatomy, endocrinology, and reproduction, followed by more detailed sections on neuroanatomy, vasculature, cell biology, and histology of particular organs and structures, and a section on molecular biology. High quality illustrations are included throughout and a color plate section is provided. A glossary, list of equipment suppliers, and "Quick Reference Section" are added features. The "Quick Reference Section" brings together all tables from the text, allowing readers to find data swiftly. The first volume in The Handbook of Experimental Animals Series, The Laboratory Rat, provides researchers in academia and industry using laboratory animals with comprehensive, practical information on the species. The Laboratory Rat has been divided into eight sections dealing with:* Strains and their selection for research* Housing and maintenance* Pathogens and diseases* Breeding and reproduction* Anatomy* Physiology* Procedures, including experimental surgery* Emerging techniques, including genetic engineering and molecular technologyKey Features* Provides a valuable, comprehensive reference source for anybody working with the laboratory rat* Formatted in a two-color, user-friendly layout* Includes high-quality illustrations throughout as well as a color plate section* Glossary* Tables in the text are also arranged into one Quick Reference Section for ease of access to the data* Appendix of equipment suppliers
Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates, Fifth Edition, emulates in design and accuracy Paxinos and Watson's The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. - 100 thoroughly revised coronal diagrams and accompanying photographic plates spaced at approximately 120 μm intervals - 32 thoroughly revised sagittal diagrams and accompanying photographic plates - 30 thoroughly revised horizontal diagrams and accompanying photographic plates - Photographic plates printed from high resolution digital images in color - The most accurate and virtually universally used stereotaxic coordinate system - Over 800 structures identified - Includes the Expert Consult eBook version, compatible with PC, Mac, and most mobile devices and eReaders, which allows readers to browse, search, and interact with content
The Rat Brain in Stereotaxic Coordinates Compact, Seventh Edition is a smaller sized (8.5 x 11inch), abridged version of the most referenced work in neuroscience (over 35,000 citations). The compact edition provides the coronal plates and diagrams of the current seventh edition in a smaller, more convenient spiral format and at a student friendly price. This book includes an introduction on current concepts in neuroanatomy, such as neuromeres and brain development. Students and seasoned researchers will find the first major unified nomenclature ontology tree based on development that features coronal photographic plates and juxtaposed diagrams. - Features 161 coronal diagrams and accompanying photographic plates spaced at constant 120 micron intervals - Includes a simplified mini-atlas for beginning neuroscientists, and for teaching purposes - Covers the most accurate and widely used stereotaxic coordinate system - Presents diagrams that are identical to those in the full Seventh Edition - Includes the Expert Consult eBook version, compatible with PC, Mac, and most mobile devices and eReaders, which allows readers to browse, search, and interact with content
No state in the entire Nation is richer in Indian names, or in fact, in Indian history than Pennsylvania. These Indian names of Pennsylvania are full of music, but, of far greater importance, they are full of history. A History of the Indian Villages and Place Names in Pennsylvania, which was first published in 1928, is the only major book of the 20th century that traces Pennsylvania’s Indian place and names for their correct form, origin and history. Its pages are filled with the most incredible collection of information ever assembled on the Indian villages of Pennsylvania and their Indian place names and is an Indian history scholar’s delight. In preparing his book, Dr. Donehoo researched every available source of printed material about Indian place names in Pennsylvania. He also walked nearly every Indian trail, from the Delaware to the Ohio, using early trader’s journals and maps as his guide, to seek out the places the Indians lived. Each Indian name comes complete with historical notes by the author. The book includes a list of all the sources used to authenticate each Indian place name. An excellent bibliography follows at the conclusion of the work along with appendixes listing: the Indian villages of New York destroyed by General Sullivan’s army in 1779, prehistoric works in Pennsylvania by county, and an alphabetical listing of all Indian named places in each county.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Highlights recent advances in opioid addiction - Includes Neurocircuitry, Cellular and Molecular neurobiological mechanisms of opioid addiction - Defines opioid abuse and addiction potential, including biological tolerance
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction are detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Psychostimulants, Volume 2 in the series, explores the molecular and cellular systems in the brain responsible for psychostimulant addiction, including both direct/indirect sympathomimetics and nonsympathomimetics. This volume introduces the readers to the history of psychostimulant use. The authors clearly differentiate the neurobiological effects into three distinct stages of the addiction cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Highlights recent advances in psychostimulant addiction - Includes neurocircuitry, cellular and molecular neurobiological mechanisms of psychostimulant addiction - Defines the abuse and addiction potentials of both direct and indirect sympathomimetics and nonsympathomimetics
Interest in the human mind is a centuries-old fascination, dating back to Plato, Aristotle, and Descartes. While the theories proposed about the human mind have since advanced and evolved, the fascination remains. Growing Minds is a unique and interdisciplinary work that guides the reader through an examination of the human mind's nature, performance, lifespan, and variations. The book sets out to answer a variety of questions: What are the cognitive processes underlying intelligence? What is general and what is specific in intelligence? What is stable and what is changing in intelligence as children grow older? Why do individuals differ in intelligence, and are differences genetically determined? How is intelligence and intellectual development related to the genome and the brain? How is intelligence related to personality? Can intelligence be enhanced by specific interventions? The text is organised into three parts: the first provides a summary and evaluation of research conducted on the human mind by experimental cognitive psychology, differential psychology, and developmental psychology. The second presents an overarching theory of the growing mind, showing how mind and intelligence are at the crossroads of nature and nurture; and the third assesses the relationship between education and intelligence. This book is the result of decades of extensive research and culminates in the proposal of a new overarching and integrated theory of the developing mind. For the first time, research is gathered and combined to form a comprehensive concept and fulfil the need for a fresh, integrative paradigm which both asks and answers questions about the human mind from a multi-faceted perspective.
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature.· Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
Introduction to Addiction, Volume One in the series, introduces the reader to the study of neurobiology of addiction by clearly defining addiction and its neuroadaptational views. This volume includes thorough descriptions of the various animal models applicable to the study of addiction, including Animal Models of the Binge-Intoxication Stage of the Addiction Cycle and Animal Models of Vulnerability to Addiction. The book's authors also include a section on numerous neurobiological theories that aid in the understanding of addiction, including dopamine, prefrontal cortex and relapse. - Provides neurobiological theories on how addiction works - Explains addiction cycle stages of binge, withdrawal and anticipation - Reviews the role of dopamine and the frontal cortex in addiction - Discusses the neurocircuitry of reward and stress - Includes animal models and neuroadaptational views on addiction
Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. - Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle - Actual data figures from original sources illustrating key concepts and findings - Introduction to basic neuropharmacology terms and concepts - Introduction to numerous animal models used to study diverse aspects of drug use. - Thorough review of extant work on the neurobiology of addiction
On the surface, John and George Esseff seem to have traveled very different paths in life: George as a successful scientist, entrepreneur, and philanthropist with a wife, children, and grandchildren; John as a celibate priest whose life has been spent mostly with the poor. But from their humble beginnings in Depression-era Wilkes-Barre, PA to this day, the Esseff brothers' lives have been very much intertwined. Their shared story takes us from the poorest places on the planet to the bastions of wealth and power, with these remarkable men touching and changing lives all along the way. Gripping and inspirational, this book is the story of faith made real in the lives of two men who are BROTHERS & FATHERS.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction - Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle - Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol
The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain. The fourth edition of this classic book is a complete revision featuring many improvements and upgrades. Constructed by the established leaders in neuroanatomical atlas development, the new edition will continue to be the indispensable resource for all scientists working on the primate nervous system. - 141 completely revised coronal diagrams and accompanying colour photographic plates spaced at approximately 120 μm intervals - 60 colour photographic coronal plates of SMI immunoreactivity with completely revised delineations - Includes MR images at approximately the same levels as the coronal diagrams - Follows the same nomenclature and abbreviations as the mouse, rat, chicken, marmoset and human brain atlases, with indications of correspondence to alternative macaque nomenclatures - This atlas was used for the delineation and nomenclature of MRI-based macaque brain atlases for neuroimaging analyses, including the SARM
Human Brainstem: Cytoarchitecture, Chemoarchitecture, Myeloarchitecture explores how the human brainstem has been impeded by the unavailability of an up-to-date, comprehensive, diagrammatic and photographic atlas. Now, with the first detailed atlas on the human brainstem in more than twenty years, this book presents an accurate, comprehensive and convenient reference for students, researchers and pathologists. - Presents the first detailed atlas on the human brainstem in more than twenty years - Represents all areas of the medulla, pons and midbrain in the plane transverse to the longitudinal axis of the brainstem - Consists of 63 plates and 63 accompanying diagrams with an interplate distance of one millimeter - Includes photographs of Nissl and acetylcholinesterase (AChE) stained sections at alternate levels - Provides an accurate and convenient guide for students, researchers and pathologists
This atlas – and its accompanying text - is the most comprehensive work on avian neuroanatomy available so far. It identifies more than 900 hundred structures (versus ca. 250 in previous avian atlases), 180 of them for the first time. It correlates avian and mammalian neuroanatomy on the basis of homologies and applies mammalian terms to homologous avian structures. This is the first atlas that represents the fundamental histogenetic domains of the vertebrate neuroaxis on the basis of sound fate-mapping and gene expression data. This results in a substantial increase in accuracy of delineations. Developmental molecular biologists will find it easier to extrapolate early neural tube patterns into mature structures. The modern trend to shift avian neuroanatomical nomenclature toward mammalian terminology by reference to postulated homologies has been expanded to the entire brain, but is not yet complete. This creates a new standard for comparative cross-reference, which can also be applied to reptilian-mammalian comparisons. - Color photographs and matching diagrams of 65 coronal, 23 sagittal and 9 horizontal 140 micron-thick sections reacted histochemically for acetylcholinesterase (AChE). - Thoroughly revised drawings. Updated view of the pallium, including the new concept of homology between the lateral pallium and the mammalian claustro-insular complex. - Extensive introductory text and bibliography, presenting the background information, methodology and justification of delineations. - For the first time in any species, this atlas depicts the fate-mapped natural embryonic boundaries in the postnatal brain. For the first time, we present color images of all the 6 histological stains (AChE, Nissl, TH, calbindin, calretinin and parvalbumin) on which delineations are based (accompanying Expert Consult eBook). - Includes the Expert Consult eBook version, compatible with PC, Mac, and most mobile devices and eReaders, which allows readers to browse, search, and interact with content. - The eBook also contains annotatable AI files of diagrams for use by researchers.
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