An authoritative guide to computer simulation grounded in a multi-disciplinary approach for solving complex problems Simulation and Computational Red Teaming for Problem Solving offers a review of computer simulation that is grounded in a multi-disciplinary approach. The authors present the theoretical foundations of simulation and modeling paradigms from the perspective of an analyst. The book provides the fundamental background information needed for designing and developing consistent and useful simulations. In addition to this basic information, the authors explore several advanced topics. The book’s advanced topics demonstrate how modern artificial intelligence and computational intelligence concepts and techniques can be combined with various simulation paradigms for solving complex and critical problems. Authors examine the concept of Computational Red Teaming to reveal how the combined fundamentals and advanced techniques are used successfully for solving and testing complex real-world problems. This important book: • Demonstrates how computer simulation and Computational Red Teaming support each other for solving complex problems • Describes the main approaches to modeling real-world phenomena and embedding these models into computer simulations • Explores how a number of advanced artificial intelligence and computational intelligence concepts are used in conjunction with the fundamental aspects of simulation Written for researchers and students in the computational modelling and data analysis fields, Simulation and Computational Red Teaming for Problem Solving covers the foundation and the standard elements of the process of building a simulation and explores the simulation topic with a modern research approach.
The 1,150 pages contain more information than any other comparable book. It is not a glossary or dictionary or review because all concepts are explained, not just defined or mentioned.Covers the latest developments, usually missed in textbooks and monographs.The broad range of modern genetics, of cell and molecular biology, biometry, etc. are included without glossing over the classical foundations.The hundreds of simple and clear illustrations are vey useful for classroom purposes because they can be drawn on the blackboard or projected on a screen without taking much time to make the crucial points.The cross-references among the entries tie the contents into an extremely useful comprehensive textbook.The concise style leads the reader to the point without verbiage.The etymology of the terms is explained.The text is not intimidating and it is very easy to read because all the terms are explained within the book. Most of the biometrical procedures are presented by worked-out examples in a plain form, rarely or not found at all in other books.It effectively reaches out to non-geneticists without compromising high scientific standards. Usually the most essential features of a concept are presented at the beginning of the entry, and the reader can go as far as she/he feels needed about the logic.The WEB and e-mail addresses of databases and other sources of detailed information are very helpful.A well selected list of about 1000 references, published mainly in the last couple of years, completes the volume.The moderate price makes it a best buy, and an excellent choice to own for students, teachers, scientists, physicians, lawyers and all educated persons who cannot afford an entire library yet wish to be well informed.
Synthetic Peptides discusses racemization, protecting group techniques, peptide bond-forming methodology, amino acids, and dipeptide syntheses. The book explains solid phase synthesis methods, cyclopeptides, nucleopeptides, chromopeptides of the actinomycin D type, and cites examples of syntheses of peptides of different sizes. The text describes tripeptides, tetrapeptides, pentapeptides, hexapeptides, and also undecapeptides to nonadecapeptides. Riniker and colleagues explain the revised structures (for the human and porcine hormone, Asn for Asp at position 25 and Glu for Gin at position 30) for the 39-unit adrenocorticotropic hormone. A synthesis of the 32-unit human calcitonin M is associated with the fragment condensation approach to complex peptides. The book also reviews cyclodepsipeptide valinomycin based on the possible transport of a potassium ion through biological membranes by this substance and the synthesis of a D-Pro analog. The text describes the cyclic decapeptide antibiotic gramicidin S, belonging to a family of similar substances isolated from Bacillus brevi, that can treat certain eye-threatening infections. The book can prove beneficial for biochemists, micro-biologists, cellular investigators, and researchers involved in physiology, oncology or therapeutics.
This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. It includes approximately 1,800 current databases and web servers. This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.
During the past ten years, several theories have been proposed on the origin of the diversity of antibodies. George P. Smith presents a critical study of these theories in this detailed treatment of immunological problems from the point of view of molecular genetics. Mr. Smith uses a new and simplifying approach to this long-standing controversy. By a comprehensive computerized analysis of antibody amino acid sequences (particularly the myeloma proteins), the author traces their evolution and matches his results against the expectations of the various theories of diversity. He discusses at length the other types of evidence as well. Mr. Smith also deals with the clonal specialization of cells to produce a single antibody, and the relationship of this specialization to the somatic joining of antibody half-genes, which is one of the immune system's most important peculiarities. Introductory material is provided to make this work understandable to molecular geneticists not versed in immunology and to immunologists not versed in molecular genetics. This is a timely book offering a succinct and coherent summary of the various lines of evidence in a confused and controversial field.
Some of Bill Clinton's most basic foreign policy elements - democratic peace, the post-Cold War peace dividend, geopolitics and state-society relations - are epitomized in the US-Russian Highly Enriched Uranium (HEU) Purchase Agreement. It was one of the most remarkable initiatives of Clinton's presidency, but oddly one of the most obscure that still continues under George W. Bush. This agreement illustrates how successfully the US and Russia could work together to reduce global nuclear fears but also how a series of decisions pitted global designs over American domestic interests. Illustrating one of the most compelling decisions Clinton made as President, this remarkable book elucidates the theory of democratic peace and demonstrates a new and more advanced nuclear restraint regime, from reduction to elimination. The story behind Clinton's decision has repercussions for our understanding of arms control, foreign policy decision making and US-Russian relations. This is a book about the intersection of levels of analysis, international security concerns and domestic political economy, and as such is ideal as a supplementary text for advanced courses in security and foreign policy.
Completely revised and updated to incorporate the latest data in the field, Lewin's CELLS, Second Edition is the ideal resource for advanced undergraduate and graduate students entering the world of cell biology. Redesigned to incorporate new learning tools and elements, this edition continues to provide readers with current coverage of the structure, organization, growth, regulation, movements, and interaction of cells, with an emphasis on eukaryotic cells. Under the direction of three expert lead editors, new chapters on metabolism and general molecular biology have been added by subject specialist. All chapters have been carefully edited to maintain consistent use of terminology and to achieve a homogenous level of detail and rigor. A new design incorporates many new pedagogical elements, including Concept & Reasoning Questions, Methods boxes, Clinical Applications boxes, and more.
This advanced chemistry text has been updated to match the specification for A Level Chemistry from September 2000. The chemical storylines and related data include the latest developments and they are split clearly into AS and A2 units.
Ideal text for undergraduate and graduate students in advanced cell biology courses Extraordinary technological advances in the last century have fundamentally altered the way we ask questions about biology, and undergraduate and graduate students must have the necessary tools to investigate the world of the cell. The ideal text for students in advanced cell biology courses, Lewin's CELLS, Third Edition continues to offer a comprehensive, rigorous overview of the structure, organization, growth, regulation, movements, and interactions of cells, with an emphasis on eukaryotic cells. The text provides students with a solid grounding in the concepts and mechanisms underlying cell structure and function, and will leave them with a firm foundation in cell biology as well as a "big picture" view of the world of the cell. Revised and updated to reflect the most recent research in cell biology, Lewin's CELLS, Third Edition includes expanded chapters on Nuclear Structure and Transport, Chromatin and Chromosomes, Apoptosis, Principles of Cell Signaling, The Extracellular Matrix and Cell Adhesion, Plant Cell Biology, and more. All-new design features and a chapter-by-chapter emphasis on key concepts enhance pedagogy and emphasize retention and application of new skills. Thorough, accessible, and essential, Lewin's CELLS, Third Edition, turns a new and sharper lens on the fundamental units of life
Cancer exacts an incredibly destructive toll on the world's human populations. In recent years we have frequently heard the expression "war on cancer," but compared to the carnage inflicted by cancer, our scientific and medical efforts, to date, would seem more like a minor skirmish. Some comprehension of the cancer problem can be obtained from a look at the current and projected casualty list for the United States. In this country, about 700,000 new cases of cancer will be diagnosed in 1976 and over 1 million known cases will continue to be treated. Over 400,000 of these patients will die from cancer in our bicentennial year. With the incidence of cancer in the United States increasing to 5.2% in 1975, compared to the 1.1 % yearly rate experienced for decades, Dr. F. J. Rauscher, Jr.,338 Director of the National Cancer Institute, has estimated that more than 10 million people will be under treatment for cancer and nearly 4 million will expire from cancer in this decade. At that rate, cancer will appear in nearly two of three families and the necessary medical care will cost some $15-20 billion per year. Thus unless methods for the treatment and control of cancer are markedly improved, about 53 million Americans now alive will eventually be cancer patients. Unfor tunately the major types of human cancer are still beyond curative care by surgical and radiological techniques and because of the paucity of currently available cancer chemotherapeutic drugs with curative potential.
Principles of Proteomics, Second Edition, provides a concise and user-friendly introduction to the diverse technologies used for the large-scale analysis of proteins, as well as their applications, and their impact in areas such as drug discovery, agriculture, and the fight against disease. Proteomics is a fast-advancing field in which researchers seek to capture all the proteins in the cell and characterize them in ever more detail. Principles of Proteomics has been fully updated to reflect the most recent developments in the field without losing its focus on the underlying principles. With worked examples, case studies profiling both established and emerging technologies, and further reading lists for each chapter, Principles of Proteomics is an ideal introduction for students, researchers and those working in the industry.
This comprehensive publication draws together the important aspects of carcinogen-cell interaction. This interesting work describes the regulation of normal cell proliferation, cellular responses to carcinogen damage, the biologic consequences of cellular DNA modification, the structural and genomic changes resulting from carcinogen insult, and the possible involvement of such changes in the conversion of normal human fibroblasts to malignant cells. It presents current reviews with up-to-date literature references and provides critical information from leading investigators that is essential in understanding the biology of human cell transformation. This volume is especially useful to advanced students in genetic toxicology, molecular biologists, and all who are interested in the molecular and macromolecular changes in human cells leading to neoplasia.
The fields of molecular biology and genetics are faced with an enormous accumulation of information: DNA sequencing, associated sequences of amino acids in proteins, genetics, macromolecular structures and other sets have created a quantitative backlog of data which needs to be organized and analyzed. Moreover, the rate of data acquisitions is accelerating as improved technologies are used and as organized programs such as the Human Genome Initiative are established. Because of this data's importance, molecular biologists have turned to computational scientists for help in processing this mass of information.The Santa Fe Institute organized a workshop on "The Interface Between Computational Science and DNA Sequencing" in 1998 to address this information crisis. Approximately one hundred molecular biologists, computer scientists, mathematicians, and other scientists in diverse fields met to discuss how computational science can best keep pace with molecular biology. The papers presented at that meeting and included in this volume serve as a comprehensive introduction to the field and as a discussion of research on some of the current problems.
Until recently, plant breeders have depended primarily on classicaltools to develop new and improved products for producers andconsumers. However, with the advent of biotechnology, breeders areincreasingly incorporating molecular tools in their breeding work.In recognition of the current state of methods and theirapplication, this text introduces both classical and moleculartools for plant breeding. Topics such as biotechnology in plant breeding, intellectualproperty, risks, emerging concepts (decentralized breeding, organicbreeding), and more are addressed in this state of the art text.The final 8 chapters provide a useful reference on breeding thelargest and most common crops. In addition, over 25 plant breedersshare their professional experiences while illustrating concepts inthe text. Features include: Comprehensive presentation of both classical and molecularplant breeding tools Industry highlight essays from over 25 professional plantbreeders Chapter introductions, summaries and discussion questions Easy reference glossary Reference chapters on breeding 8 of the largest and most commoncrops Artwork from the book is available to instructors online at ahref="http://www.blackwellpublishing.com/acquaah"www.blackwellpublishing.com/acquaah/a.An Instructor manual CD-ROM for this title is available. Pleasecontact our Higher Education team at ahref="mailto:HigherEducation@wiley.com"HigherEducation@wiley.com/afor more information.
Focuses on the fundamental aspects of molecular structure and funciton by reviewing key features, and along the way, capsulizing them as a series of concise concepts. Users are encouraged to place the essential knowledge of molecular biology into broad contexts and develop both academic and personal meaning for this discipline.
Nuclear disarmament is firmly back on the international agenda. But almost all current thinking on the subject is focused on the process of reducing the number of weapons from thousands to hundreds. This rigorous analysis examines the challenges that exist to abolishing nuclear weapons completely, and suggests what can be done now to start overcoming them. The paper argues that the difficulties of 'getting to zero' must not preclude many steps being taken in that direction. It thus begins by examining steps that nuclear-armed states could take in cooperation with others to move towards a world in which the task of prohibiting nuclear weapons could be realistically envisaged. The remainder of the paper focuses on the more distant prospect of prohibiting nuclear weapons, beginning with the challenge of verifying the transition from low numbers to zero. It moves on to examine how the civilian nuclear industry could be managed in a nuclear-weapons-free world so as to prevent rearmament. The paper then considers what political-security conditions would be required to make a nuclear-weapons ban enforceable and explores how enforcement might work in practice. Finally, it addresses the latent capability to produce nuclear weapons that would inevitably exist after abolition, and asks whether this is a barrier to disarmament, or whether it can be managed to meet the security needs of a world newly free of the bomb.
Drawn from presentations made at the Hoover Institution's October 2007 conference, this collection of essays examines the practical steps necessary to address the current security challenges of nuclear weapons and to move toward the Reykjavik goal of eliminating all nuclear weapons. The distinguished group of contributors includes former officials of the past six administrations—Republican and Democratic—along with senior scholar and scientific experts on nuclear issues.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
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