A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Highlights recent advances in opioid addiction Includes Neurocircuitry, Cellular and Molecular neurobiological mechanisms of opioid addiction Defines opioid abuse and addiction potential, including biological tolerance
Introduction to Addiction, Volume One in the series, introduces the reader to the study of neurobiology of addiction by clearly defining addiction and its neuroadaptational views. This volume includes thorough descriptions of the various animal models applicable to the study of addiction, including Animal Models of the Binge-Intoxication Stage of the Addiction Cycle and Animal Models of Vulnerability to Addiction. The book's authors also include a section on numerous neurobiological theories that aid in the understanding of addiction, including dopamine, prefrontal cortex and relapse. Provides neurobiological theories on how addiction works Explains addiction cycle stages of binge, withdrawal and anticipation Reviews the role of dopamine and the frontal cortex in addiction Discusses the neurocircuitry of reward and stress Includes animal models and neuroadaptational views on addiction
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction are detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Psychostimulants, Volume 2 in the series, explores the molecular and cellular systems in the brain responsible for psychostimulant addiction, including both direct/indirect sympathomimetics and nonsympathomimetics. This volume introduces the readers to the history of psychostimulant use. The authors clearly differentiate the neurobiological effects into three distinct stages of the addiction cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Highlights recent advances in psychostimulant addiction Includes neurocircuitry, cellular and molecular neurobiological mechanisms of psychostimulant addiction Defines the abuse and addiction potentials of both direct and indirect sympathomimetics and nonsympathomimetics
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol
The anthology "Impulse Control Disorders" brings together diverse authors and works to highlight key components of a variety of disorders, and gives students a unique view of impulse control disorders from the perspective of self-regulation failure and addiction. The book explores impulsivity and impulse control disorders in pathology in order to understand how such pathology evolves to form elements of some of the most severe disorders of our time. Chapters 1 and 2 address the social psychology domain, exploring many of the principles of self-regulation failure in the social arena. Chapters 3, 4, and 5 deal with the addiction domain. The impulse control disorders discussed in Chapters 6 through 15 are explored within the contexts of self-regulation failure and addiction. Chapters 16 through 18 examine the transition from impulse control disorders to compulsive disorders, and well-documented psychiatric disorders. The brain mechanisms that drive self-regulation failure are explored throughout the text, but a specific focus on regulation failure and stress is provided in Chapter 20. "Impulse Control Disorders" provides essential background reading for a complete course. It can also be used in courses on drugs, addiction, and pharmacology. In addition, the material is very helpful to professionals in the field who wish to compare and evaluate disorders. George F. Koob, Ph.D. is a Professor, and Chair of the Committee on the Neurobiology of Addictive Disorders at The Scripps Research Institute. Dr. Koob is also an Adjunct Professor in the Departments of Pharmacy and Pharmaceutical Sciences at the University of California, San Diego where he has taught upper division and graduate level courses on drugs, addiction and pharmacology. Dr. Koob has published over 700 scientific papers and received continuous funding for his research from the National Institute of Health. He has been honored as a Highly Cited Researcher by the Institute for Scientific Information, and received the Daniel Efron Award for excellence in research from the American College of Neuropsychopharmacology. In addition, he received the Distinguished Investigator Award from the Research Society on Alcoholism, and the Mark Keller Award from the National Institute on Alcohol Abuse and Alcoholism.
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle Actual data figures from original sources illustrating key concepts and findings Introduction to basic neuropharmacology terms and concepts Introduction to numerous animal models used to study diverse aspects of drug use. Thorough review of extant work on the neurobiology of addiction
The key to escape addiction is to deconstruct the intense pleasure memories linked to it and to create new memories of happiness with others. This book presents helpful tools to accomplish this mission. The goal is to motivate patients to change their operating mode, give hope to their families and improve the work of those taking care of them"--
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
It has been over 50 years since Hans Selye formulated his concept of stress. This came after the isolation of epinephrine and norepinephrine and after the sympathetic system was associated with Walter Cannon's "fight or flight" response. The intervening years have witnessed a number of dis coveries that have furthered our understanding of the mechanisms of the stress response. The isolation, identification and manufacture of gluco corticoids, the identification and synthesis of ACTH and vasopressin, and the demonstration of hypothalamic regulation of ACTH secretion were pivotal discoveries. The recent identification and synthesis of CRR by Willie Vale and his colleagues gave new impetus to stress research. Several new concepts of stress have developed as a result of advances in bench research. These include the concept of an integrated "stress sys tem", the realization that there are bi-directional effects between stress and the immune system, the suggestion that a number of common psychiatric disorders represent dysregulation of systems responding to stress, and the epidemiologic association of stress with the major scourges of humanity.
Insightful interviews of horror legends George Romero, John Landis, Joe Dante, Brian Yuzna, and more, by former editor-in-chief of Rue Morgue, Dave Alexander, about the scariest horror movies never made! Take a behind-the-scenes look into development hell to find the most frightening horror movies that never were, from unmade Re-Animator sequels to alternate takes on legendary franchises like Frankenstein and Dracula! Features art, scripts, and other production material from unmade films that still might make you scream--with insights from dozens of directors, screenwriters, and producers with decades of experience. Featured Interviews With: George A. Romero John Landis Joe Dante Vincenzo Natali Brian Yuzna William Lustig William Malone Buddy Giovinazzo Tim Sullivan Richard Raaphorst Ruggero Deodato Jim Shooter Bob Layton David J. Skal
This excellent book is a concise yet thorough examination of the important and emerging field of the study of biological risk factors in drug abuse. Historically, drug abuse research has concentrated on the contributions of environmental and behavioral factors as the major influences on addiction. The revelatory studies in this volume examine the genetic contributions to drug taking behavior through the use of animal models, cellular experiments and human clinical studies. Behavioral and Biochemical Issues in Substance Abuse provides for the first time in one volume, up-to-date, easily digested reviews of topics concerning biological and genetic factors in drug abuse. Medical researchers in all areas of alcoholism and drug abuse, researchers in pharmacology, psychology, psychiatry and neuroscience, and clinicians interested in biological approaches to alcoholism and drug abuse problems will benefit greatly from this valuable resource. Authoritative contributors clearly demonstrate the capability of genetic factors to modulate the reinforcing or rewarding effects of drugs, thereby altering their addictive potential. In addition to gaining comprehension of the biological factors affecting addiction, a greater understanding of genetics related to drug abuse will enable future research to control biological factors, leading to more accurate studies of behavioral and environmental influences on drug and alcohol abuse.
Psychology is of interest to academics from many fields, as well as to the thousands of academic and clinical psychologists and general public who can't help but be interested in learning more about why humans think and behave as they do. This award-winning twelve-volume reference covers every aspect of the ever-fascinating discipline of psychology and represents the most current knowledge in the field. This ten-year revision now covers discoveries based in neuroscience, clinical psychology's new interest in evidence-based practice and mindfulness, and new findings in social, developmental, and forensic psychology.
This long-awaited update of the classic, The Human Nervous System, stands as an impressive survey of our knowledge of the brain, spinal cord, and peripheral nervous system. The book has been completely redone and brought up-to-date. An impressive and respected cast of international authors have contributed 37 chapters on topics ranging from Brain Evolution, all phases of Brain Development, to all areas of the adult brain and peripheral pathways, along with careful descriptions of the spinal cord and peripheral nervous system, brainstem and cerebellum. The Human Nervous System, Second Edition will again serve as the gold standard, providing a one-stop source of up-to-date information about our knowledge of the human nervous system. This second edition of the standard reference on the human nervous system is extensively and completely revised and updated from the 1990 first edition. Written by the leading researchers, many chapters have been completely rewritten, new chapters have been added. A new section on Evolution and Development provides a broader perspective, and all chapters include references and perspectives to neurological disease.
Stay on top of the rapid changes sweeping endocrinology today with the latest information on important selected topics in The Handbook of Endocrinology. This extensive two-volume text provides an impressive breadth and depth of coverage difficult to find in other sources. After a broad survey of the functions of major endocrine glands, the book launches into detailed reviews of both established and hot, new research areas. Selected topics include:
Introduction to Addiction, Volume One in the series, introduces the reader to the study of neurobiology of addiction by clearly defining addiction and its neuroadaptational views. This volume includes thorough descriptions of the various animal models applicable to the study of addiction, including Animal Models of the Binge-Intoxication Stage of the Addiction Cycle and Animal Models of Vulnerability to Addiction. The book's authors also include a section on numerous neurobiological theories that aid in the understanding of addiction, including dopamine, prefrontal cortex and relapse. Provides neurobiological theories on how addiction works Explains addiction cycle stages of binge, withdrawal and anticipation Reviews the role of dopamine and the frontal cortex in addiction Discusses the neurocircuitry of reward and stress Includes animal models and neuroadaptational views on addiction
The Disordered Mind, Third Edition, is a wide-ranging introduction to the philosophy of mental disorder or illness. It examines and explains, from a philosophical standpoint, what mental disorder is: Its reality, causes, consequences, compassionate treatment, and more. Revised and updated throughout, the third edition includes enhanced discussions of the distinction between mental health and illness, selfhood and delusions about the self, impairments of basic psychological capacities in mental disorder, and the distinct roles that mental causation and neural mechanisms play in mental illness. The book is organized around four questions: • What is a mental disorder or illness? • What makes mental disorder something bad? • What are various mental disorders and what do they tell us about the mind? • What is mental health and how may it be restored? Numerous disorders are discussed, including addiction, agoraphobia, delusion, depression, dissociative identity disorder, obsession-compulsion, schizophrenia, and religious scrupulosity, among others. Several neurological disorders are examined. Various problems associated with DSM-5 and with psychiatric diagnosis are explored. Including chapter summaries and suggestions for further reading, The Disordered Mind is an ideal text for courses in philosophy and should appeal to not just philosophers, but to readers in cognitive science, psychology, psychiatry, and related mental health professions.
This book contains the papers delivered at the 1996 Copper Scroll Symposium which was organized by the Manchester-Sheffield Centre for Dead Sea Scrolls Research to mark the 40th Anniversary of the opening of this enigmatic scroll in Manchester. The papers cover the history of the Scroll's interpretation (P. Muchowski, P. Davies, B. Segal, M. Wise); how it should be conserved, restored and read (N. Cacoudre, M. Lundberg, E. Puech); how it was produced (P. Kyle McCarter); the meaning of its technical terms (J.F. Elwolde, A. Lange, J. Lefkovits, J. Lubbe, L. Schiffman); its genre (M. Bar-Ilan, R. Fidler, T. Lim); its geography (P.S. Alexander); its correlation with archaeological remains (H. Eshel); and not least who wrote it, when and why (S. Goranson, I Knohl, H. Stegemann, B. Thierine, A. Wolters) with an Introduction by G. Brooke. This is volume 40 in the Journal for the Study of Pseudepigrapha Supplement series.
With a subtle yet penetrating understanding of the intricate interplay of gender, race, and class, Sheba George examines an unusual immigration pattern to analyze what happens when women who migrate before men become the breadwinners in the family. Focusing on a group of female nurses who moved from India to the United States before their husbands, she shows that this story of economic mobility and professional achievement conceals underlying conditions of upheaval not only in the families and immigrant community but also in the sending community in India. This richly textured and impeccably researched study deftly illustrates the complex reconfigurations of gender and class relations concealed behind a quintessential American success story. When Women Come First explains how men who lost social status in the immigration process attempted to reclaim ground by creating new roles for themselves in their church. Ironically, they were stigmatized by other upper class immigrants as men who needed to "play in the church" because the "nurses were the bosses" in their homes. At the same time, the nurses were stigmatized as lower class, sexually loose women with too much independence. George's absorbing story of how these women and men negotiate this complicated network provides a groundbreaking perspective on the shifting interactions of two nations and two cultures.
Thoroughly updated for its Sixth Edition, Handbook of Psychiatric Drug Therapy is one of the most popular guides to the essential facts about all drugs used to treat anxiety, depression, bipolar disorders, psychotic disorders, substance abuse disorders, sleep disorders, dementia, and attention deficit disorder. Coverage of each drug includes mechanisms of action, indications, side effects, interactions, method of use, and caveats regarding special populations such as pregnant and elderly patients. The book gives specific prescribing recommendations—including dosage and duration of use—for individual drugs. Tables provide at-a-glance information and a disease-specific table of contents directs readers quickly to relevant drug chapters.
Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.
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