George J. Brewer's Books

Wilson’s Disease

A Clinician’s Guide to Recognition, Diagnosis, and Management

By: George J. Brewer

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Wilson’s Disease

A Clinician’s Guide to Recognition, Diagnosis, and Management

By: George J. Brewer

Movement disorder specialists, general neurologists, hepatologists, general gastroenterologists, and psychiatrists are the specialists who will most likely see some Wilson's disease patients during their careers. See them - yes. Recognize and diagnose them - maybe. If you are in one of these specialties, and a patient with tremor, hepatitis, cirrhosis, apparent Parkinsonism, or mood disorder, is referred to you, will you appropriately recognize the possibility that the underlying diagnosis may be Wilson's disease? Wilson's disease is both treatable and reversible, and commonly misdiagnosed. This book aims to change this with comprehensive coverage of every aspect of Wilson's disease, from well-catalogued, easy-to-use clinical diagnostic tools to treatment methods to molecular biology. Dr. Brewer is the world's leading expert on Wilson's disease, seeing and caring for over 300 patients with the disease during the last 20 years. He is a professor of human genetics at the University of Michigan.

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Page Count

222

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461516455

ISBN 13

9781461516453

From Start to Finish

By: George J. Brewer

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From Start to Finish

By: George J. Brewer

From Start to Finish is a series of five autobiographical vignettes of Dr. Brewer’s life. It’s a little different from typical autobiographies in that it doesn’t start in the beginning and chronologically and methodically tell the story of a life. Rather it is divided into five sections that, while they generally proceed in chronological order, are also divided by setting and topics. Thus, the first section, “Tales from Life on the Farm,” while providing information on his childhood, is dominated by his father’s Depression-spawned concept that his boys needed to learn to farm, liberally sprinkled with his other firm belief that by using a little ingenuity, he “could make a million dollars.” Readers should find this group of tales interesting and often humorous. Beyond this they will gain a snapshot of the “rural-poor” in post-Depression America. His father was an avid hunter and fisherman, and as a boy George joined in those activities with great enthusiasm. As with the farm tales, the second part of the book, “Tales from Woods and Waters,” gives a glimpse of something perhaps a little different, a boy’s view of hunting and fishing with his father. As George grew up, he retained an interest in fishing, and a little of that adult interest, with anecdotes mostly about fishing with his dad, are included. As George finished high school, he decided to go to college, even with very little financial resources, stimulated strongly by four older siblings who had gone to college, also in spite of few financial resources. “Tales from Schools and Hospitals,” the third part of the book, is a little about his decision to go to pharmacy school and a little about his college experiences. However, it is much more about his motivations to follow a career path in medicine, about his experiences in medical school, as well as in a residency in internal medicine. Readers will see medical school and medicine from a view they’re not used to, up close and personal, and always with an eye toward the humor in the situation. The fourth part is indeed unique. After residency in internal medicine, Dr. Brewer spent four years in the Stateville Penitentiary, a maximum security prison in Joliet, Illinois. Quickly, it should be said before the reader jumps to the conclusion that they’re reading the words of a convicted felon, that he was a scientist in charge of studies being done there by the University of Chicago, funded by the U.S. Army. The work there involved malaria research, and that work has been a key in the development of antimalarial drugs still used around the world. But what has been done in “Tales from Jail,” besides talk about some fascinating things related to malaria research, is to give the reader a peek inside a prison such as this, and a peek at the inmates who were the project’s nurses, technicians, clerks, and malaria subjects. Dr. Brewer felt he needed one more piece of “tooling” before settling down into the medical research career. He wanted to know more about human genetics. So off to the University of Michigan for a postdoctoral experience in that topic. Finally, all tooled up, he was ready for a real job, and accepted a faculty position at the University of Michigan, where he has been ever since (35 years and counting!). “Tales from the Halls of Science” is the story of his academic medical research career, told in layman’s language. This section provides some perspective on what such a career is like, its up, its downs, the depressing disappointments, the highs of the occasional successes, and what it is that motivates most scientists to work so hard. His career is ending on a series of highs, so those readers who like happy endings should be satisfied. Some of the things a reader can take away from this book are as follows. First, that in this country a very impoverished but determined youngster c

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250

Publisher

Xlibris Corporation

Published Date

ISBN 10

1462838901

ISBN 13

9781462838905

Environmental Causes and Prevention Measures for Alzheimer’s Disease

By: George J. Brewer

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Environmental Causes and Prevention Measures for Alzheimer’s Disease

By: George J. Brewer

Environmental Causes and Prevention Measures for Alzheimer’s Disease examines the increased incidence of the disease in developed countries and aims to educate neuroscientists, medical practitioners and other educated individuals on new insights into environmental causation, primarily metals. This book looks into the web of evidence around the hypothesis of copper toxicity and the additional role that a high fat diet plays in disease progression and cognition loss. The data and its implications are discussed, along with potential prevention measures. This book will generate excitement and interest among neuroscientists, medical practitioners and other biomedical researchers. Emphasizes the history and epidemiology of Alzheimer’s disease, highlighting its epidemic proportions in developed countries Discusses data on new environmental factors in developed countries Provides prevention measures to potentially reduce Alzheimer’s rates through diet

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156

Publisher

Academic Press

Published Date

ISBN 10

0128111631

ISBN 13

9780128111635

The H Campus

By: George J. Brewer

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The H Campus

By: George J. Brewer

When Scott Jordan, a well trained physician took a neurology training fellowship with a famous neurologist, Sven Aldred, he had ulterior motives. Scotts mother had worked for Aldred as a live in maid prior to and a short time after Scotts birth. She became afraid Aldred was experimenting on Scotts brain and hid him with relatives. Shortly thereafter she died a mysterious death. Now Scott, an unknown to Aldred, had returned to investigate his mothers death, as well as Aldreds very mysterious scientific activities. In the process, Scott runs into a situation of multiple murders, extreme exploitation, and selfish greed that threaten to engulf and destroy Scott and others around him.

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230

Publisher

Xlibris Corporation

Published Date

ISBN 10

146283891X

ISBN 13

9781462838912

The Death Gene

By: George J. Brewer

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The Death Gene

By: George J. Brewer

As most everyone who reads the newspapers these days will be aware, DNA technology and cloning genes (isolating and obtaining the DNA for a specific gene) is on the cutting edge of science. Almost every week a new gene is cloned, its DNA sequence determined, and its function discovered. Discoveries of genes that cause specific diseases, even some cancers (such as breast cancer), are being made on a regular basis. The gene that is discovered in the present story is, at present, fictional. It is a gene that promotes the aging process, and therefore, it promotes death. The flip side of the gene is that if its action is turned off by a new drug, as it is in the story, it stops aging and allows an unlimited life-span. Neither the discovery of such a gene, or its manipulation by a drug, are at all far-fetched. In fact, it can be anticipated that such a gene probably will be discovered sooner or later. This is a story about what happens when such a gene, and a way to turn it off, are discovered. Story Line It all started with something seemingly trivial, the interruption of the usual behavior of the pet mice in Dr. Al Grogans laboratory. A world-class physician-scientist in his mid-fifties, Grogan has been spending long evenings in his lab and office trying to solve a riddle. Why had one of his discoveries, a promising new long-acting contraceptive called DNA-C129, quit working? The unusual squeaks and sounds of protest from the mice interrupted Grogans concentration. The reason the mice are disturbed is obvious. Maria, Grogans new lab assistant, an attractive lady in her late thirties, has disturbed the mice by peering closely at them. Initially disgruntled at the interruption, Grogan nevertheless demonstrates to Maria a trick he had taught the mice. Maria asks about the age of the mice and Grogan says theyre maybe four years old, since they were part of the original DNA-C129 experiments. Maria, who has had considerable experience studying mouse aging, contradicts her boss, saying that mice of this strain simply dont live that long. In human terms, they would be the equivalent of two-hundred years old! Grogan, who now realizes he isnt very well-informed about mouse life-span, tells Maria he was probably mistaken about the age of the mice. But he knows they are really about four years old, and his mind starts churning excitedly about some of the possible effects of DNA-C129, and about the reason it may have stopped working. With this new clue, things begin to snap into place in Grogans mind. DNA-C129 had quit working when he had lost his junior partner, a younger man named Bowdler, who had been carrying out the actual experiments under Grogans general supervision. Bowdler had been killed in an auto accident. Grogan now realizes that DNA-C129 has antiaging properties, and probably owes its long-lasting effects to Bowdler doing an outlaw experiment, namely using an illegal vector (the viral-like particle that delivers the therapy DNA), one that had not been authorized by Grogan. The keys to DNA-C129 effects, including its antiaging effects, no doubt lay not only in its own innate properties, but in the vector Bowdler had used. With Bowdlers death, and with Grogan now using the standard vector, DNA-C129 had lost its properties in Grogans experiments. During the next four months the Grogan lab becomes a beehive of activity as Grogan sets out to test these ideas. As the work goes on, a romance develops between Grogan and Maria. However, Grogan is very secretive about the purpose of the experiments, even with Maria. He works for a modest-sized biotech company, in Madison, Wisconsin, called DNA Unlimited, and he doesnt trust management. He codes all the results, and mixes up the experiments in such a manner that no single technician has a complete picture of the studies and the results. During this time Grogan places regular calls to a former student, and current best friend, Kirk Starge

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335

Publisher

Xlibris Corporation

Published Date

ISBN 10

1462838898

ISBN 13

9781462838899

Wilson's Disease for the Patient and Family

A Patient's Guide to Wilson's Disease and Frequently Asked Questions About Copper

By: George J. Brewer

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Wilson's Disease for the Patient and Family

A Patient's Guide to Wilson's Disease and Frequently Asked Questions About Copper

By: George J. Brewer

Wilsons Disease for the Patient and Family: A Patients Guide to Wilsons disease and Frequently asked Questions about Copper, is an essential reference book for patients with Wilsons disease and their families. In easy-to-understand language, Dr. Brewer, a world authority on Wilsons disease and copper, explains everything about Wilsons disease, from its genetic cause and mechanism of transmission, to effective treatment plans. A comprehensive glossary provides readers with definitions and explanations for many of the scientific words and phrases used in the text. Major reasons why this book is important to patients relate to the rarity of the disease, variation in its manner of presentation, and the likelihood that doctors consulted about the medical problems will know very little about Wilsons disease. Most doctors, even specialists in liver disease or neurology, will see at most one or two cases during their entire medical careers. If patients hope for rapid and early diagnosis, and that is important to preserve as much function as possible, they may need to help the doctor think of the disease in the first place, and help in sorting out what constitutes proper diagnosis. And then, if there is a diagnosis, comes treatment. The days are gone when one drug, penicillamine (the only anticopper drug most doctors have heard of), is prescribed as soon as the diagnosis is made. Now we have different therapies for different stages. In fact, we no longer recommend penicillamine for Wilsons disease at all. This book will guide the patient and family through all of these various aspects of Wilsons disease. Dr. Brewer begins by describing Wilsons disease, what causes it, how it is inherited, and what symptoms people with Wilsons disease exhibit. It is an inherited disorder of copper accumulation and toxicity, affecting one in 40,000 people worldwide. After basic coverage of Wilsons disease, Dr. Brewer devotes an entire chapter to answering some of the most commonly asked questions about copper. Many of these questions are unrelated to Wilsons disease, but are questions frequently asked by other types of patients as they are informed that there is something wrong with their copper. After that, Dr. Brewer explores the symptoms which should trigger the suspicion of Wilsons disease, and what screening tests can be done to explore this possibility. He then covers testing which will give a definitive diagnosis, what the results of different tests mean, and some of the possible problems with various tests which might be performed. Once a reliable diagnosis of Wilsons disease is made, anticopper therapy is essential to the survival of Wilsons disease patients. Dr. Brewer explains what drugs are available for treatment of Wilsons disease, and offers a comparison of their benefits and side effects. He elaborates on variations in treatment, first discussing the initial stage of treatment, and then long-term maintenance therapy. Included in the discussion are tips for treatment of children and pregnant women. The risks and long-term outlook for a person diagnosed with Wilsons disease are discussed in some detail. After these information-packed chapters, Dr. Brewer devotes a chapter to answering some frequently asked questions about Wilsons disease, and presents resources available to Wilsons disease patients and their families. The book concludes as Dr. Brewer examines the current shortcomings in Wilsons disease therapy, and points to areas which might be improved upon in the future.

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154

Publisher

Xlibris Corporation

Published Date

ISBN 10

146283888X

ISBN 13

9781462838882

The Bloodcicle Agent

By: George J. Brewer

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The Bloodcicle Agent

By: George J. Brewer

Peter Faulkner, a graduate student in microbiology, called his wife to tell her hed be late, and made the mistake of calling from his mentors office. Catching Peter in his presumably locked office when he returned unexpectedly, Professor Jergens was enraged, mistakenly thinking Peter had seen secret material. The Professors suspicions set in motion a series of events that, before they had run their course, led to numerous deaths that seemed to be due to some mysterious poison or infection. Peter found himself in the middle, accused of the murders, and fighting for his life to try to solve the mystery of what was causing the deaths. The agent was extremely mysterious, killing but leaving no trace of itself. Could Peter solve the mystery of this deadly agent, while being hounded by powerful and sinister forces that didnt want this secret exposed?

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258

Publisher

Xlibris Corporation

Published Date

ISBN 10

1465324615

ISBN 13

9781465324610

Introduction to Sociology

By: George Ritzer,J. Michael Ryan

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Introduction to Sociology

By: George Ritzer,J. Michael Ryan

Introduction to Sociology offers a comprehensive guide that connects traditional sociological concepts and contemporary social phenomena, such as globalization, consumer culture, the internet, and "McDonaldization," to students′ lives in today′s global society. This accessible text encourages learners to apply a sociological perspective and explore how public sociologists address critical modern issues. This title is accompanied by a complete teaching and learning package. Contact your Sage representative to request a demo. Learning Platform / Courseware Sage Vantage is an intuitive learning platform that integrates quality Sage textbook content with assignable multimedia activities and auto-graded assessments to drive student engagement and ensure accountability. Unparalleled in its ease of use and built for dynamic teaching and learning, Vantage offers customizable LMS integration and best-in-class support. It’s a learning platform you, and your students, will actually love. Learn more. Assignable Video with Assessment Assignable video (available in Sage Vantage) is tied to learning objectives and curated exclusively for this text to bring concepts to life. Watch a sample video now. LMS Cartridge: Import this title’s instructor resources into your school’s learning management system (LMS) and save time. Don’t use an LMS? You can still access all of the same online resources for this title via the password-protected Instructor Resource Site. Learn more.

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Page Count

894

Publisher

SAGE Publications

Published Date

ISBN 10

1071875159

ISBN 13

9781071875155

Book's by George J. Brewer

Wilson’s Disease

Wilson’s Disease

From Start to Finish

From Start to Finish

Environmental Causes and Prevention Measures for Alzheimer’s Disease

Environmental Causes and Prevention Measures for Alzheimer’s Disease

The H Campus

The H Campus

The Death Gene

The Death Gene

Wilson's Disease for the Patient and Family

Wilson's Disease for the Patient and Family

The Bloodcicle Agent

The Bloodcicle Agent

Introduction to Sociology

Introduction to Sociology

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