Handbook of Fillers, Fourth Edition, discusses the rapidly advancing field of fillers, the substances added to plastics and composites that add value by improving and modifying the properties of materials and reducing costs. This new edition is an essential reference for engineers and scientists using fillers in a range of materials, including plastics, rubber, adhesives, and paper. The book is designed to be a comprehensive reference for both experienced practitioners and those new to fields where fillers are used. It covers available fillers and their properties, their effect on filled materials, such as mechanical properties, rheology, morphology, flammability, and recycling, and their use in practical applications. In particular, this new edition provides extensive coverage of nanofillers, along with the practical information needed to deploy these new technologies in the real world. The book includes the latest advances in filler technology, with consolidated technical information from over 4,000 research papers, data from over 160 filler and equipment manufacturers, and a thorough review of the patent literature. - Provides up-to-date, applicable information on the use of fillers in plastics, rubber, adhesives, and paper - Presents comprehensive coverage on the effect of fillers on materials, including their mechanical properties, their effects on material rheology, the morphology of the filled system, material durability, and more - Includes essential guidance on the industrial scale use of fillers and their transportation, storage, processing, equipment, quality control, and health and safety considerations
This book will be the first book that presents the beneficial effects of hydrogen sulfide in the treatment of various kidney pathologies. Hydrogen sulfide (H2S), a gas with a distinctive smell of rotten eggs, was known for over three centuries for its toxicity and death at high concentrations especially among agricultural and industrial workers. This is due to its ability to reversibly antagonize complex IV of the mitochondrial electron transport chain. However, studies over the past two decades have shown that H2S has risen above its historic notorious label and has received significant experimental attention as an endogenously produced gaseous signaling molecule that plays an important role in cellular homeostasis and influences a myriad of physiological and pathological processes at low concentrations. Its production is enzymatically regulated and has specific molecular targets. Several recent in vitro and in vivo studies have demonstrated that at low micromolar concentrations, H2S exhibits important therapeutic characteristics that target multiple molecular pathways and thereby preventing the development and progression of several pathologies. This beneficial effect of H2S suggests that it may meet the demand for alternative and/or additional therapeutic agents against various renal pathologies in which reduced levels of renal and plasma H2S were observed. Interestingly, while the distribution of H2S-producing enzymes is tissue-specific, they are abundantly expressed in the glomeruli and in the brush border and cytoplasm of epithelial cells of the renal tubules and in the peritubular capillaries. This makes the kidney a rich source of endogenous H2S production. From pre-clinical and clinical perspectives, this book is topical and timely, and seeks to lay the foundation for future clinical applications of H2S in nephrology.
The Editors for this issue of Otolaryngologic Clinics, Dr George Wanna and Dr Matthew Luke Carlson, envisioned a publication that reviews the evaluation and management of common ear and lateral skull base tumors. Intended audience includes Otologists, Neurotologists, General otolaryngologists and Neurosurgeons alike. The development of management of lateral skull base tumors has been rapid, in the past 40 years there has been a tremendous shift toward conservative therapy for benign lesions. Focused chapters review specific pathologies plus a chapter focused on stereotactic radiotherapy. Topics written by reputed leaders in the field of Otology and skull base tumors include: Imaging of temporal bone lesions; Squamous cell carcinoma of the temporal bone; Glomus tympanicum; Adenomatous tumors of the middle ear; Intralabyrinthine schwannomas; Vestibular schwannoma; Neurofibromatosis2 (including ABI and CI); Non-schwannoma tumors of the CPA; Glomus jugulare; Endolymphatic sac tumors; Non-paraganglioma jugular foramen tumors; Primary tumors of the facial nerve; Cholesterol granuloma and other petrous apex lesions; Stereotactic radiosurgery for tumors of the lateral skull base; Pediatric temporal bone malignancy; and Historical perspective on evolution in management of lateral skull base tumors.
Concise yet comprehensive, the Biomedical Technology and Devices Handbook illuminates the equipment, devices, and techniques used in modern medicine to diagnose, treat, and monitor human illnesses. With topics ranging from the basic procedures like blood pressure measurement to cutting-edge imaging equipment, biological tests, and genetic engineeri
Used by generations of physicians who encounter patients with dermatological diseases, Lever’s Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a “primer” on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis—all in an easy-to-navigate, highly readable format.
Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.
This authoritative book presents the theoretical development of gravitational physics as it applies to the dynamics of celestial bodies and the analysis of precise astronomical observations. In so doing, it fills the need for a textbook that teaches modern dynamical astronomy with a strong emphasis on the relativistic aspects of the subject produced by the curved geometry of four-dimensional spacetime. The first three chapters review the fundamental principles of celestial mechanics and of special and general relativity. This background material forms the basis for understanding relativistic reference frames, the celestial mechanics of N-body systems, and high-precision astrometry, navigation, and geodesy, which are then treated in the following five chapters. The final chapter provides an overview of the new field of applied relativity, based on recent recommendations from the International Astronomical Union. The book is suitable for teaching advanced undergraduate honors programs and graduate courses, while equally serving as a reference for professional research scientists working in relativity and dynamical astronomy. The authors bring their extensive theoretical and practical experience to the subject. Sergei Kopeikin is a professor at the University of Missouri, while Michael Efroimsky and George Kaplan work at the United States Naval Observatory, one of the world?s premier institutions for expertise in astrometry, celestial mechanics, and timekeeping.
Reflecting the expertise and perspective of five leading mammalogists, the fourth edition of Mammalogy: Adaptation, Diversity, Ecology significantly updates taxonomy, includes a new chapter on mammalian molecular phylogenetics, and highlights several recently described species. There are close to 5,500 species in the class Mammalia, including the blue whale—the largest animal that has ever lived—and the pygmy shrew, which weighs little more than a penny. The functional diversity of mammals has allowed them to play critical roles in every ecosystem, whether marine, freshwater, alpine, tundra, forest, or desert. Many mammal species are critically endangered and present complex conservation and management challenges. This book touches on those challenges, which are often precipitated by overharvesting and habitat loss, as well as emerging threats, such as the impact of wind turbines and white nose syndrome on bats and chronic wasting disease on deer. Among the updates and additions to the fourth edition of Mammalogy are numerous new photos, figures, and cladograms, over 4,200 references, as well as • A completely new chapter on mammalian phylogeny and genomics • Current taxonomy—including major changes to orders, suborders, and superfamilies of bats and rodents • An explanation of the recent inclusion of whales with terrestrial even-toed ungulates • Updates on mammalian structural, functional adaptations, and fossil history • recent advances in our understanding of phylogeny, biogeography, social behavior, and ecology • A discussion of two new orders and thirteen newly recognized extant families • Reflections on the implications of climate change for mammals • Thorough examinations of several recently described species, including Durrell's vontsira (Salanoia durrelli) and the Laotian rock rat (Laonastes aenigmamus) • An explanation of mammalian biomechanics, such as that seen in lunge feeding of baleen whales • Breakout boxes on unique aspects of mammals, including the syntax of bat songs, singing mice, and why there are no green mammals (unless we count algae-covered sloths) Maintaining the accessible, readable style for which Feldhamer and his coauthors are well known, this new edition of Mammalogy is the authoritative textbook on this amazingly diverse class of vertebrates.
Comprising the terms and phrases of American jurisprudence, including ancient and modern common law, international law, and numerous select titles from the civil law, the French and the Spanish law, etc.,etc. With an exhaustive collection of legal maxims.
Atlas of Material Damage, Third Edition provides a systematic analysis of modes of damage and morphology of damaged material and compares the experiences of different industries to provide insights into the most frequently encountered failures, reasons for these failures, and potential improvements to prevent future failure. The book covers defect formation, material damage, and how structure of materials impacts designed function. The effects of composition, processing conditions, and singular and combined actions of different degradants on industrial products are discussed at length. Technological steps required to obtain specifically designed morphology for specific performance are outlined, and numerous examples of how this special morphology can be achieved and deployed in electronics, plastics, pharmaceuticals, aerospace, automotive, medical, dental and a range of other fields and applications is also covered. - Analyzes modes of damage, morphology of damaged material, and the effects of composition, morphological features, and structure of materials on material performance, durability and resilience - Provides numerous examples on how optimal material structure and morphology can be achieved in a variety of different applications - Compares frequently encountered failure scenarios, their causes and ways to avoid them
Overviews manufacturing systems from the ground up, following the same concept as in the first edition. Delves into the fundamental building blocks of manufacturing systems: manufacturing processes and equipment. Discusses all topics from the viewpoint of four fundamental manufacturing attributes: cost, rate, flexibility and quality.
The aim of this book is to present in one volume some of the most significant developments that have taken place in the field of integrated ferroelectrics during the last decade of the twentieth century. The book begins with a comprehensive introduction to integrated ferroelectrics and follows with fifty-three papers selected by Carlos Paz de Arauj
This book offers a conceptual explanation of the interrelationships that exist between the stages in the progression of initiated epithelial cells in culture compared with the diverse tissue of organs and the progression of tumors from different organ sites. The fate of the modification of adducts is discussed at the molecular level. The role that modifications in hot spots in oncogenes and supressor genes play at the molecular level and how these molecular modifications can lead to an explanation of molecular control in the formation of tumor phenotypes is also examined. Researchers in cell biology and toxicology, applied pharmacology, carcinogenesis, teratogenesis, mutagenesis, and molecular toxicology will find the book useful, interesting reading.
Completely revised and updated to incorporate the latest data in the field, Lewin's CELLS, Second Edition is the ideal resource for advanced undergraduate and graduate students entering the world of cell biology. Redesigned to incorporate new learning tools and elements, this edition continues to provide readers with current coverage of the structure, organization, growth, regulation, movements, and interaction of cells, with an emphasis on eukaryotic cells. Under the direction of three expert lead editors, new chapters on metabolism and general molecular biology have been added by subject specialist. All chapters have been carefully edited to maintain consistent use of terminology and to achieve a homogenous level of detail and rigor. A new design incorporates many new pedagogical elements, including Concept & Reasoning Questions, Methods boxes, Clinical Applications boxes, and more.
Airway Management in Emergencies 2/e covers all the options both medical and surgical for managing any patient's airway in an emergency. Here, you'll find the core knowledge and accompanying management protocols necessary to assess, oxygenate, intubate and monitor patients requiring emergency airway management. This new edition expands coverage of airway management in the pre-hospital environment and chapters on airway management with airway and systemic co-morbidities. Additionally, there is enhanced content to appeal to various clinicians (MD and non-MD eg. Paramedics). Key Features
This book presents a broad exposition of analytical and numerical methods for modeling composite materials, laminates, polycrystals and other heterogeneous solids, with emphasis on connections between material properties and responses on several length scales, ranging from the nano and microscales to the macroscale. Many new results and methods developed by the author are incorporated into the rich fabric of the subject, which has developed from the work of many researchers over the last 50 years. Among the new results, the book offers an extensive analysis of internal and interface stresses caused by eigenstrains, such as thermal, transformation and inelastic strains in the constituents, which often exceed those caused by mechanical loads, and of inelastic behavior of metal matrix composites. Fiber prestress in laminates, and modeling of functionally graded materials are also analyzed. Furthermore, this book outlines several key subjects on modeling the properties of composites reinforced by particles of various shapes, aligned fibers, symmetric laminated plates and metal matrix composites. This volume is intended for advanced undergraduate and graduate students, researchers and engineers interested and involved in analysis and design of composite structures.
Covering a comprehensive range of common, rare, benign and malignant lesions, Pathology of the Female Reproductive Tract, 3rd Edition, authored by an international panel of subspecialty experts, brings you the latest scientific and diagnostic information for diseases of the female reproductive tract. From basic concepts of pathophysiology and diagnostic criteria to clinical correlation, this updated medical reference book delivers an integrated and practical approach to diagnosis and management of women with reproductive tract disorders. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Quickly and easily access key information with user-friendly bullet points, diagnostic flowcharts, decision-making algorithms, summary tables, and take-home messages, as well as a "Road Map" at the beginning of each chapter for effortless navigation. - Avoid diagnostic errors with the help of practical, expert advice on common pitfalls in differential diagnosis. - Take optimal advantage of the most recent and clinically useful ancillary diagnostic methods, including molecular biomarkers, immunohistochemistry, and genetic studies. - Provide the most accurate and up-to-date diagnostic and prognostic indicators possible by familiarizing yourself with the latest classification and staging systems for all diseases and disorders of the female genital tract. - Stay completely current on the latest histological and molecular standards for diagnosis and prognosis. - Clearly visualize the appearance of each tumor or tumor-like lesion being discussed through improved and updated images.
For ophthalmologists who are already using femtosecond lasers as well as those just starting out who are looking for the definitive reference manual, Femtosecond Lasers in Cornea and Lens Surgery is a comprehensive, cutting-edge guide to this technology that features a robust supplemental website with nearly 40 surgical videos. With the advent of small incision lenticule extraction, pockets and channels for corneal inlays and ring segments, femtosecond lasers for corneal surgery have advanced significantly over the past several decades, and ophthalmologists are looking for expert guidance on their acquisition, utilization, and optimization. With contributions from world-renowned surgeons who have seen the benefit of integrating femtosecond laser technology into their practices, this text reviews the practical aspects of femtosecond technology and also addresses the future of this quickly evolving space. Drs. George O. Waring, IV and Karolinne Maia Rocha lead their team of more than 50 expert contributors in providing a thorough, definitive text summarizing all aspects of femtosecond lasers for corneal and lens surgery in a balanced and commercially unbiased manner. All of the major platforms and systems are covered in chapters including: Integration of Femtosecond Laser–Assisted Cataract Surgery Into Your Practice Therapeutic Laser Assisted Cataract Surgery Complications of Femtosecond LASIK Small Incision Lenticule Extraction Femtosecond Laser Pockets for Corneal Inlays Use of Femtosecond Lasers in Keratoplasty For a comprehensive resource on the use of femtosecond lasers in cornea and lens surgery, as well as unbiased opinions from expert contributors on the various procedures and platforms, Femtosecond Lasers in Cornea and Lens Surgery is a must-have for ophthalmologists wishing to stay on top of this evolving field.
Personalized and continuing relationships play a central role in any society. Economists have built upon the theories of repeated games and reputations to make important advances in understanding such relationships. Repeated Games and Reputations begins with a careful development of the fundamental concepts in these theories, including the notions of a repeated game, strategy, and equilibrium. Mailath and Samuelson then present the classic folk theorem and reputation results for games of perfect and imperfect public monitoring, with the benefit of the modern analytical tools of decomposability and self-generation. They also present more recent developments, including results beyond folk theorems and recent work in games of private monitoring and alternative approaches to reputations. Repeated Games and Reputations synthesizes and unifies the vast body of work in this area, bringing the reader to the research frontier. Detailed arguments and proofs are given throughout, interwoven with examples, discussions of how the theory is to be used in the study of relationships, and economic applications. The book will be useful to those doing basic research in the theory of repeated games and reputations as well as those using these tools in more applied research.
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