This new third edition updates a best-selling encyclopedia. It includes about 56% more words than the 1,392-page second edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. It includes approximately 1,800 current databases and web servers. This encyclopedia covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, and patents. Similar integrated information is not available in textbooks or on the Internet.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Highlights recent advances in opioid addiction - Includes Neurocircuitry, Cellular and Molecular neurobiological mechanisms of opioid addiction - Defines opioid abuse and addiction potential, including biological tolerance
A new scholarly edition of an Ohio boy soldier’s revealing post-Civil War memoir. This annotated edition of Holliday’s recollections—known primarily among historians of the American West—re-contextualizes his memoir to include his boyhood in southern Ohio and the largely untold story of the hundreds of Buckeyes who crossed the Ohio River to serve their country in Virginia (later West Virginia) regiments, ultimately traveling across Kansas, Nebraska, Colorado, and Wyoming to safeguard mail and stage routes along the celebrated Oregon Trail during a pivotal time in American history. Glenn Longacre’s extensive research in federal, state, and local archives, manuscript collections, and period newspapers complements his correspondence with the living descendants of Holliday and other soldiers. His research integrates this story deservedly as part of Appalachian history before, during, and after the Civil War. From this perspective it addresses an entirely new audience of Appalachian studies scholars, Civil War and frontier history enthusiasts, students, and general readers.
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