Written by the famed inventor’s granddaughter herself for builders of all ages, this is the only official guide to building 25 kid-friendly Rube Goldberg Machines at home To build a Rube Goldberg Machine, all you need is a pile of junk and a great imagination. Rube Goldberg’s granddaughter, Jennifer George, has teamed up with world-renowned Rube Goldberg machine builder Zach Umperovitch to show us just how true that is in this comprehensive guide to building Rube Goldberg Machines at home. Written in partnership with Rube Goldberg’s granddaughter herself, Jennifer George, this book breaks down how to build a variety of machines that solve simple problems in complex ways. Progressing in difficulty with each chapter, kids (and builders of all ages) will learn how to construct super simple machines that fit on a tabletop, to hard ones that take up entire rooms or yards! Learn how to start chain reactions that refill your popcorn automatically on movie night, open umbrellas, and even pack a picnic, one step at a time. Filled with jokes, fun facts, and tips and tricks to make building as successful as possible, this book is sure to satisfy every family’s most curious and inventive minds!
If Rube’s inventions are any indication, “normal” means something very different in the Goldberg household. For Rube, up is down, in is out, and the simplest path to accomplishing an everyday task—like brushing his teeth or getting dressed—is a humorously complicated one. Follow Rube as he sets out on a typical school day, overcomplicating each and every step from the time he wakes up in the morning until the time he goes to bed at night. This book features fourteen inventions, each depicting an interactive sequence whose purpose is to help Rube accomplish mundane daily tasks: a simple way to get ready for school, to make breakfast, to do his homework, and so much more.
Follow along with young inventor Rube Goldberg on his day off from school in this wacky, STEAM-focused picture book A “definitely different” follow-up to Rube Goldberg’s Simple Normal Humdrum School Day, written by Jennifer George, the granddaughter of Rube Goldberg, and illustrated by award-winning artist Ed Steckley. In their latest collaboration, they imagine Rube Goldberg as a young inventor who builds complex machines to solve simple, everyday problems. Follow along as he invents zany chain-reaction contraptions to have the best day off from school ever—including a simple way to play fetch in the yard without leaving his bedroom, a self-operating swing, and a super simple series of movie snacking machines.
Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg ulation in causing disease and the utility of dopamine agonists and an tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con sequences of stimulating pre-and postsynaptic dopamine receptors. Research in dopamine pharmacology mirrors the remarkable ad vances that are occurring in the field of pharmacology at large as a con sequence of the involvement of an ever-larger number of scientific dis ciplines in the study of drug action.
When Detective Tom Cavanaugh finds himself the prime suspect in a series of brutal murders on Staten Island, he impulsively leaves New York for Havana, Cuba with his girl friend to find his half-brother, Jesuit priest Jack Bennis, who he believes correctly is also in serious trouble. What Cavanaugh doesnt realize initially, but soon finds out the hard way, is both he and his brother are the targets of an international assassin, Cain Holland, who follows Cavanaugh from the streets of Brooklyn, through Canada, to the streets of Old Havana and Vedado, Cuba. While the hunt for the New York killer, who mutilates his victims, pours maple syrup over them and leaves nursery rhymes intensifies, Cavanaugh and Bennis fight for their lives in Cuba as Cavanaughs partner tries to clear his partner and solve the mystery of the Maple Syrup Killer.
In this unflinching look at white supremacy, George Lipsitz argues that racism is a matter of interests as well as attitudes, a problem of property as well as pigment. Above and beyond personal prejudice, whiteness is a structured advantage that produces unfair gains and unearned rewards for whites while imposing impediments to asset accumulation, employment, housing, and health care for minorities. Reaching beyond the black/white binary, Lipsitz shows how whiteness works in respect to Asian Americans, Latinos, and Native Americans.Lipsitz delineates the weaknesses embedded in civil rights laws, the racial dimensions of economic restructuring and deindustrialization, and the effects of environmental racism, job discrimination and school segregation. He also analyzes the centrality of whiteness to U.S. culture, and perhaps most importantly, he identifies the sustained and perceptive critique of white privilege embedded in the radical black tradition. This revised and expanded edition also includes an essay about the impact of Hurricane Katrina on working class Blacks in New Orleans, whose perpetual struggle for dignity and self determination has been obscured by the city's image as a tourist party town.
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature.· Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
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