In eleventh century Constantinople, treachery and subterfuge are the hallmarks of courtly intrigue. Newly wed Justin Phillipos is a heavy cavalryman who, along with several other comrades and his best friend, fellow horseman Peter Argyropoulos, is about to be honored for his bravery at the court of Emperor Romanos Diogenes. As he kisses his wife Eleni farewell, he has no idea that their lives will soon be in great peril. Romanos has a shaky hold on his power as he and his allies grow more unpopular. His demise is plotted by many. He sees a military victory against the marauding Seljuk Turks as the only way to bolster his waning power. He pulls Justin and Peter into a secret meeting in the Basilica Cistern and reveals to them the political intrigue of which they are now a part. Romanos assigns them to the command of Andronikos Dukas, one of the chief conspirators plotting the emperor’s demise. Eleni will be held in custody at the Palace Bucoleon by Empress Evdokia. She fears she will never see her husband again. As this epic drama unfolds across two continents, only time will tell if the military gambit will succeed or the plotting of antagonists will topple the precarious empire. Will the young soldiers survive? Will wife and husband share another passionate embrace?
The fourth edition of Numerical Methods Using MATLAB® provides a clear and rigorous introduction to a wide range of numerical methods that have practical applications. The authors' approach is to integrate MATLAB® with numerical analysis in a way which adds clarity to the numerical analysis and develops familiarity with MATLAB®. MATLAB® graphics and numerical output are used extensively to clarify complex problems and give a deeper understanding of their nature. The text provides an extensive reference providing numerous useful and important numerical algorithms that are implemented in MATLAB® to help researchers analyze a particular outcome. By using MATLAB® it is possible for the readers to tackle some large and difficult problems and deepen and consolidate their understanding of problem solving using numerical methods. Many worked examples are given together with exercises and solutions to illustrate how numerical methods can be used to study problems that have applications in the biosciences, chaos, optimization and many other fields. The text will be a valuable aid to people working in a wide range of fields, such as engineering, science and economics. - Features many numerical algorithms, their fundamental principles, and applications - Includes new sections introducing Simulink, Kalman Filter, Discrete Transforms and Wavelet Analysis - Contains some new problems and examples - Is user-friendly and is written in a conversational and approachable style - Contains over 60 algorithms implemented as MATLAB® functions, and over 100 MATLAB® scripts applying numerical algorithms to specific examples
Theatre and Aural Attention investigates what it is to attend theatre by means of listening. Focusing on four core aural phenomena in theatre – noise, designed sound, silence, and immersion - George Home-Cook concludes that theatrical listening involves paying attention to atmospheres.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Opioids, Volume 4 in the series, explores the molecular, cellular and systems in the brain responsible for opioid addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Highlights recent advances in opioid addiction - Includes Neurocircuitry, Cellular and Molecular neurobiological mechanisms of opioid addiction - Defines opioid abuse and addiction potential, including biological tolerance
Team-working, partnership, quality circles, works councils, industrial democracy, empowerment - are they distinct and innovative arrangements or is it a case of new wine in old bottles? In the post war period we have seen numerous forms of organizational participation sometimes as experiments, sometimes as negotiated expediency, and sometimes as hype. Different ideas have emerged from different parts of the world, in different industries, at different times with different objectives. In this book four experienced international analysts take the longer view and look at the changing forms of - and changing debates around - orgnaizational participation. The review an extensive literature of experiments and practical experiences through a critical evaluation of the available data to reach balanced conclusions about the importance and utility of this concept for organizations now and in the future.
Now with SAGE Publishing, and co-authored by one of the foremost authorities on sociological theory, George Ritzer and Jeffrey Stepnisky’s Classical Sociological Theory, Seventh Edition, provides a comprehensive overview of the major theorists and schools of sociological thought from the Enlightenment roots of theory through the early 20th century. The integration of key theories with biographical sketches of theorists and the requisite historical and intellectual context helps students to better understand the original works of classical authors as well as to compare and contrast classical theories. New to this Edition · In Ch. 1, Colonialism is now discussed as a major social force in development of modern society. · In Ch. 2, there is an expanded discussion of the historical significance of Early Women Founders and the contributions of W.E.B. Du Bois. · The chapter on Du Bois (Ch. 9) includes new material about his intellectual influences. · New contemporary commentary about Durkheim has been added to Ch. 7. · Ch. 9 includes new material from recently translated later writings of George Simmel, providing new context for his overall theory. · Addition of Historical Context boxes throughout text. · Sections on contemporary applications of classical theory have been added to each chapter.
Reviews of Environmental Contamination and Toxicology publishes authoritative reviews on the occurrence, effects, and fate of pesticide residues and other environmental contaminants. It will keep you informed of the latest significant issues by providing in-depth information in the areas of analytical chemistry, agricultural microbiology, biochemistry, human and veterinary medicine, toxicology, and food technology.
Values at Work is an analysis of organizational dynamics with wide-ranging implications in an age of market globalization. It looks at the challenges businesses face to maintain people-oriented work systems while remaining successful in the larger economy. George Cheney revisits the famous Mondragón worker-owned-and-governed cooperatives in the Basque Country of Spain to examine how that collection of innovative and democratic businesses is responding to the broad trend of marketization. The Mondragón cooperatives are changing in important ways as a direct result of both external pressures to be more competitive and the rise of consumerism, as well as through the modification of internal policies toward greater efficiency. One of the most remarkable aspects of the changes is that some of the same business slogans now heard around the globe are being adopted in this set of organizations renowned for its strongly held internal values, such as participatory democracy, solidarity, and equality. Instead of emphasizing the special or unique qualities of the Mondragón experience, this book demonstrates the case's relevance to trends in all sectors and across the industrialized world.
The thought-provoking, timely second edition continues to offer a comprehensive, global perspective on organizational communication. The authors multinational experience, consulting and teaching expertise, enthusiasm for their subject, and engaging style of writing create an inviting foundation for the exploration of this multifaceted topic. Each chapter demonstrates the practicality of theory and how practice contributes to the development of theory, while challenging readers to build on established knowledge to develop new approaches to the pressing problems in complex, multicultural organizations. The text is organized topically around the most important issues in organizational communication. Five themes recur throughout the chapters: the interdependence of internal and external forms of organizational communication, the disciplinarity and multidisciplinarity of organizational communication, global and multicultural perspectives of organizational communication, the unity of theory and practice, and critical thinking in the analysis of organizational messages and discourses. Discussions highlight language and symbolism. The authors weave analysis of the multiple levels of messages throughout the chapters; stimulate critical thinking about contemporary work and organizational life; approach the familiar as unfamiliar; ask probing questions about commonly accepted practices; and offer more imaginative ways of working together. Readers gain an appreciation for the social, political, economic, technological, and ideological contexts in organizationsand the place of organizations within the broader culture. The authors lead by example in encouraging readers to think about, talk about, and experience organizational communication in entirely new ways.
Self-Healing Materials: Principles and Technology, Second Edition provides engineers and researchers in both industry and academia the information they need to deploy self-healing technology in a range of potential applications, from adhesives to the automotive industry, and from electronics to biomedical implants. Sections discuss the principal mechanisms of self-healing and how these are applied to the development of materials that have the ability to repair themselves, either with minimal or no human intervention. In addition, the book provides a theoretical background and a review of the major research undertaken to date, providing a thorough grounding in this concept and related technology. Other sections compare the parameters of different self-healing technological processes, such as fault detection mechanisms, methods of triggering and turning off the healing processes, the activation energy of self-healing processes, the means and methods of delivery of the healing substances to the defect locations, self-healing timescale (rate of self-healing), and the extent of self-healing (healing efficiency, recovery of properties, etc.). In addition, mathematical modeling of the processes of self-healing (molecular dynamics simulation), the morphology of healed areas, and other important topics are thoroughly discussed. - Helps materials scientists and engineers reduce risk of degradation and materials failure by using self-healing materials in a range of applications - Provides real-world application examples so practitioners can assess the applicability and usefulness of self-healing materials in their work - Includes guidance on the efficiency and efficacy of self-healing mechanisms, with coverage of different parameters considered and methodologies used - Discusses typical aids and additives in self-healing materials, including plasticizers, catalysts, shape-memory components, and more
Targeted for chemists, the current textbook outlines the principles, experimental methods and data analysis in X-Ray Absorption Spectroscopy (XAS). The authors introduce EXAFS, Near-Edge XAS, X-Ray Imaging and many other advanced experimental techniques. A special section of the book is devoted to applications of XAS in chemistry, materials and environmental sciences.
Presents a unique study of Integrative Problem-Solving (IPS). The consideration of 'Decadence' is essential in the scientific study of environmental and other problems and their rigorous solution, because the broad context within which the problems emerge can affect their solution. Stochastic reasoning underlines the conceptual and methodological framework of IPS, and its formulation has a mathematical life of its own that accounts for the multidisciplinarity of real world problems, the multisourced uncertainties characterizing their solution, and the different thinking modes of the people involved. Only by interpolating between the full range of disciplines (including stochastic mathematics, physical science, neuropsychology, philosophy, and sociology) and the associated thinking modes can scientists arrive at a satisfactory account of problem-solving, and be able to distinguish between a technically complete problem-solution, and a solution that has social impact.
Report into the Loss of the SS Titanic is a complete re-evaluation of the loss of Titanic based on evidence that has come to light since the discovery of the wreck in 1985. This collective undertaking is compiled by eleven of the world's foremost Titanic researchers – experts who have spent many years examining the wealth of information that has arisen since 1912. Following the basic layout of the 1912 Wreck Commission Report, this modern report provides fascinating insights into the ship itself, the American and British inquiries, the passengers and crew, the fateful journey and ice warnings received, the damage and sinking, rescue of survivors, the circumstances in connection with the SS Californian and SS Mount Temple, and the aftermath and ramifications that followed the disaster. The book seeks to answer controversial questions, such as whether steerage passengers were detained behind gates, and also reveals the names and aliases of all passengers and crew who sailed on Titanic's maiden voyage. Containing the most extensively referenced chronology of the voyage ever assembled and featuring a wealth of explanatory charts and diagrams, as well as archive photographs, this comprehensive volume is the definitive 'go-to' reference book for this ill-fated ship.
Handbook of Plasticizers, Fourth Edition provides a comprehensive review of the current literature as well as cutting-edge details on plasticizers obtained from renewable resources. The book specifies the typical properties of plasticizers belonging to one of thirty-one groups, including expected properties in a given group. The mechanisms of plasticizers, plasticization production steps, and their material behavior in plasticized systems are outlined, along with theoretical background to help readers understand practical observations and methods of material improvement. Other chapters cover the effects on the physical and mechanical properties of plasticized materials, their use in polymers, processing defects formation, and more. This is an essential professional reference, providing R&D scientists, production chemists, and engineers the information they need to avoid certain plasticizers in applications where they may cause health or material durability problems. In addition, the book shows readers how and where to use plasticizers more effectively. - Provides detailed coverage of thirty-one groups of plasticizers, covering their properties, production, processing, applications, health and environmental aspects - Contains new material on odors in plastic materials and their removal - Includes expanded coverage of plasticizers from renewable resources
An accessible and comprehensive introduction to key concepts in globalization written by leading authors in the field In the comprehensively revised Third Edition of Globalization: A Basic Text, distinguished researchers and authors George Ritzer and Paul Dean deliver an up-to-date introduction to major trends and topics related to the study of globalization. The book includes accessible and rigorous material on the key theories and major topics in globalization, as well as modern developments like the rise of populism and far-right political groups, Brexit, migration and backlash to it, trade negotiations, social media and the spread of misinformation, climate change, social justice issues, and COVID-19. The new edition includes a greater focus on the structures of inequality that encourage or discourage global flows. Additionally, new examples and sources from Central and South America, Africa, and Asia are used to illustrate key concepts, and round out the international coverage of book. Throughout, the authors use clear and helpful metaphors including solids, liquids, gases, and flows to introduce and explain the complex nature of globalization in an engaging and understandable way. Readers will also benefit from the inclusion of: A thorough introduction to globalization and related processes, including imperialism, colonialism, development, and westernization An exploration of neoliberalism, including its roots, principles, criticisms, and Neo-Marxist alternatives A practical discussion of global political structures and processes, as well as global economic flows of production and consumption A concise treatment of negative global flows and processes, including dangerous imports, diseases, crime, terrorism, and war Analysis of the changing nature of globalization and de-globalization, and the social movements and technological developments driving these changes More images, charts, and graphs to help illustrate and highlight the concepts contained in the book Perfect for advanced undergraduates studying globalization across sociology, political science, geography, anthropology, and economics, Globalization: A Basic Text, Third Edition will also be essential reading for students taking courses in culture, economy and inequality, and migration taught from a global perspective.
In August. 1982. a conference was held at the University of Califor nia. Davis. to discuss both molecular and traditional approaches to plant genetic analysis and plant breeding. Papers presented at the meeting were published in Genetic Engineering of Plants: An Agricultural Perspective. A second conference. entitled "Tailoring Genes for Crop Improvement." spon sored by the UC-Davis College of Agricultural and Environmental Sciences and the College's Biotechnology Program. was held at Davis in August. 1986. to discuss the notable advances that had been made during the intervening years in the technology for gene modification. transfer. and expression in plants. This volume contains papers that were presented at this meeting and provides readers with examples of how the new experimental strategies are being used to gain a clearer understanding of the biology of the plants we grow for food and fiber; it also discusses how molecular biology approaches are being used to introduce new genes into plants for plant breeding programs. We are grateful to the speakers for their excellent presentations for the conference and extend our sincere thanks to those who contributed manuscripts for this volume.
Worldwide, cervical cancer is the most common form of cancer in females under 35 years of age and the second most common in females of all ages. Limitations of the existing diagnostic methods have led to the development of new diagnostic approaches. Acetic acid is a marker used for more than 70 years in gynaecology and can identify the transformation zone and detect acetowhitening changes identified as abnormal, while normal areas are not affected. A new Multispectral Imaging Spectroscopy System has been designed and developed (MIS-Colposcope). The MIS-Colposcopy is based on the quantitative and objective assessment of the acetic acid-cervical tissue interaction by means of the Multispectral Imaging Spectroscopy System (MIS-Colposcope). The method was used for the in vivo detection of cervical intraepithelial neoplasia and the results, from measurements of 123 women, indicated that there is a strong correlation between the histological condition of the tissue and the kinetics of the acetowhitening development. The best fit of the time course measurements of acetowhitening was achieved by the triple exponential function. Statistical analysis of several parameters that characterise the acetowhitening kinetics, had indicated that the combined evaluation of the parameters that express the duration and the intensity of acetowhitening differentiates sufficiently all the examined histological conditions. Estimation of the sensitivity and the specificity of this method indicate that its diagnostic performance is comparable or better than that of the existing methods. The authors' data show that this approach may be used as a sensitive and specific non-invasive colposcopic method for the diagnosis of cervical lesions and for the accurate classification of intraepithelial neoplasias.
Based on the author’s scholar-activist interventions to promote social justice in cities, this book highlights the role engaged communication scholarship can play in fostering a more equitable future. Through three innovative case studies situated in South Los Angeles, the book illustrates engaged communication scholarship projects grounded in design criteria that are social justice-oriented, place-based, collaborative, and public. It models university-community partnerships that promote positive social change in marginalized communities that stand to benefit the most from university resources, guiding readers in how these partnerships can be incorporated into social justice-oriented curriculum and engaged learning projects. It provides strategic recommendations for how "in community" communication research and media practices can be used to build local power in marginalized urban neighborhoods, and calls for communication’s research, pedagogy, epistemologies, practices, ethics, politics, and community engagement to purposefully serve the concerns of marginalized groups in society. The book will be of interest to researchers and social change practitioners interested in solution-oriented work in cities within the fields of research methods, organizational communication, urban planning, public policy, sociology, and social work.
Free boundary problems arise in an enormous number of situations in nature and technology. They hold a strategic position in pure and applied sciences and thus have been the focus of considerable research over the last three decades. Free Boundary Problems: Theory and Applications presents the work and results of experts at the forefront of current research in mathematics, material sciences, chemical engineering, biology, and physics. It contains the plenary lectures and contributed papers of the 1997 International Interdisciplinary Congress proceedings held in Crete. The main topics addressed include free boundary problems in fluid and solid mechanics, combustion, the theory of filtration, and glaciology. Contributors also discuss material science modeling, recent mathematical developments, and numerical analysis advances within their presentations of more specific topics, such as singularities of interfaces, cusp cavitation and fracture, capillary fluid dynamics of film coating, dynamics of surface growth, phase transition kinetics, and phase field models. With the implications of free boundary problems so far reaching, it becomes important for researchers from all of these fields to stay abreast of new developments. Free Boundary Problems: Theory and Applications provides the opportunity to do just that, presenting recent advances from more than 50 researchers at the frontiers of science, mathematics, and technology.
A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. - Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction - Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle - Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol
Cleft Lip and Palate Management: A Comprehensive Atlas—with more than 400 photographs and illustrations—provides the latest concepts about the surgical/orthodontic interrelation in cleft lip and palate treatment. Dr. Bennun and his team detail the diagnostic techniques to determine the best treatment protocols for optimal results and decreased chance of retreatment. The first part explains the principles of cleft and palate treatment, including the role of tissue engineering in craniofacial surgery. Part 2 details the aspects of primary surgical reconstruction, Part 3 discusses orthodontic treatments of cleft lip and palate, including a chapter on adult treatment, and Part 4 covers how to improve results in interdisciplinary treatment. Case presentations include results of treatment after 20-year follow up visits. Ideal for oral and maxillofacial surgeons, pediatric plastic surgeons, orthodontists, pediatric dentists, and residents in these specialties.
This is a "how-to" book for lovers of theater. Follow one man's successful career in acting, directing, and finally founding theaters. A FLAME entertains and serves as a road map to a meaningful life in the performing arts.
This volume in the 21st Century Oxford Authors series offers readers a generous selection of the poetry upon which Byron's fame depended and his reputation now rests. It presents the poems in the chronological order in which they were published, working in almost every case from their first appearances in print. The Selected Writings include the entirety of Byron's two best-known works, Childe Harold's Pilgrimage and Don Juan, but the decision to work book-by-book means that they are presented not as unified works but as evolving serial publications, interspersed with other works published between installments or sequels. Alongside these two major works, wider representation is given to Byron's lyric poetry than has been typical in modern editions. Furthermore, in keeping with the 21st Century Oxford Authors series, the works are reproduced in something close to their original printed forms. Prioritizing the event of publication over that of composition, this volume offers a version of Byron close to how he would have been known to his original public. With extensive annotations, it emphasizes the social processes by which literary works come to exist in the world, particularly their publication and reception histories. The result is a fresh view of Byron's literary achievement and an impetus to further reading in the works of this extraordinary creative figure.
A new and accessible edition of the letters and journals of one of Britain's most famous writers, this collection offers a biography of Byron in his own remarkable words.
This devotional starts with page "Day 1" and ends with "Day 365," just an easy way of starting this book. Discover its simple language and expressions of admiration for God and God's creation and the truths of His word. This book of devotions and reflections is for the new believer or seasoned follower as well for the one who is just now seeking Him. I challenge all to read one every day, until all 365 have been read. Are you up to the challenge? While everyone needs to hear the good news of Christ, I reach out to the outdoors sportsmen and sportswomen. For this is my niche, and my writing of each adventure is the gift He has provided me. All through my writings of enjoyment, and as I meet my fellow sportsperson in His wild, experiencing God in His creation, in the moment, brings an awareness and/or a renewed love for the Father. Through an outdoor adventure of fishing, hunting, camping, and backpacking, a deeper understanding of His Word comes to life. As we enjoy our passions in life of the great outdoors, how amazing it is to share with others Christ and His love for them. Just as Christ taught the disciples while walking down a road or in a fishing boat, I get to share who He is with my fellow adventurers, making the connection of the outdoors with the Creator. Taking time to praise, worship, and pray while casting a line or walking a trail or waiting for the morning sun, He is there. Keeping us ready to carry Him into our everyday life.
Appearing in a trendy 80s beard, Michael was seen with Ridgeley onstage at Live Aid on 13 July 1985 (surprisingly they did not sing as Wham!). Michael sang "Don't Let the Sun Go Down on Me" with Elton John, while Ridgeley sang with Kiki Dee in the row of backing singers. In September, Wham! did it right and released the single "I'm Your Man" which went to No. 1 in the UK charts.
Significant changes in surgical training have occurred over the past decade, with the inevitable progress towards specialization in the various surgical specialties. The current edition of Essential Surgical Practice: Higher Surgical Training in General Surgery reflects these latest developments with a new structure that accurately mirrors current surgical training. This new edition excludes surgical specialties that are distinct from general surgery, allowing an increased focus on topics of direct relevance to trainees in higher surgical training. Over 31 chapters, the book provides detailed information on those specialties of which the general surgeon is required to have a working knowledge, and highlights core information for revision and quick reference. Topics include: Surgical biology and pathology Surgical craft approaches and technologies Perioperative care Cardiovascular, pulmonary and renal pathophysiology Surgical infections Interventional radiology Trauma and head injuries Disorders of the thyroid and adrenal glands Disorders of the stomach, liver, spleen, colon and pancreas Bariatric surgery This book can be used with confidence by those enrolled in local courses and is also consistent with the scope and level of information required for international postgraduate examinations, such as the Joint Surgical Colleges’ Fellowship Examination. To enhance the book’s utility, the print edition includes complimentary access to a VitalSource ebook online and offline on your PC or Mac, iPhone®/iPod Touch®/ iPad®, Kindle Fire or AndroidTM device.
Inorganic nanoparticles are among the most investigated objects nowadays, both in fundamental science and in various technical applications. In this book the physical properties of nanowires formed by nanoparticles with elongated shape, i.e. rod-like or wire-like, are described. The transition in the physical properties is analyzed for nanorods and nanowires consisting of spherical and rod-like nanoparticles. The physical properties of nanowires and elongated inorganic nanoparticles are reviewed too. The optical, electrical, magnetic, mechanical and catalytic properties of nanowires consisting of semiconductors, noble and various other metals, metal oxides properties and metal alloys are presented. The applications of nanorods and nanowires are discussed in the book.
Spatiotemporal Environmental Health Modelling: A Tractatus Stochasticus provides a holistic, conceptual and quantitative framework for Environmental Health Modelling in space-time. The holistic framework integrates two aspects of Environmental Health Science that have been previously treated separately: the environmental aspect, which involves the natural processes that bring about human exposure to harmful substances; and the health aspect, which focuses on the interactions of these substances with the human body. Some of the fundamental issues addressed in this work include variability, scale, uncertainty, and space-time connectivity. These topics are important in the characterization of natural systems and health processes. Spatiotemporal Environmental Health Modelling: A Tractatus Stochasticus explains why modern stochastics is the appropriate mechanical vehicle for addressing such issues in a rigorous way. In particular, modern stochastics incorporates concepts and methods from probability, classical statistics, geostatistics, statistical mechanics and field theory. The authors present a synthetic view of environmental health that embraces all of the various components and focuses on their mutual interactions. Spatiotemporal Environmental Health Modeling: A Tractatus Stochasticus includes new material on Bayesian maximum entropy estimation techniques and space-time random field estimation methods. The authors show why these methods have clear advantages over the classical geostatistical estimation procedures and how they can be used to provide accurate space-time maps of environmental health processes. Also included are expositions of diagrammatic perturbation and renormalization group analysis, which have not been previously discussed within the context of Environmental Health. Finally, the authors present stochastic indicators that can be used for large-scale characterization of contamination and investigations of health effects at the microscopic level. This book will be a useful reference to both researchers and practitioners of Environmental Health Sciences. It will appeal specifically to environmental engineers, geographers, geostatisticians, earth scientists, toxicologists, epidemiologists, pharmacologists, applied mathematicians, physicists and biologists.
PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.
Toxic Plants of North America, Second Edition is an up-to-date, comprehensive reference for both wild and cultivated toxic plants on the North American continent. In addition to compiling and presenting information about the toxicology and classification of these plants published in the years since the appearance of the first edition, this edition significantly expands coverage of human and wildlife—both free-roaming and captive—intoxications and the roles of secondary compounds and fungal endophytes in plant intoxications. More than 2,700 new literature citations document identification of previously unknown toxicants, mechanisms of intoxication, additional reports of intoxication problems, and significant changes in the classification of plant families and genera and associated changes in plant nomenclature. Toxic Plants of North America, Second Edition is a comprehensive, essential resource for veterinarians, toxicologists, agricultural extension agents, animal scientists, and poison control professionals.
This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.
The authority on building empirical models and the fitting of such surfaces to data—completely updated and revised Revising and updating a volume that represents the essential source on building empirical models, George Box and Norman Draper—renowned authorities in this field—continue to set the standard with the Second Edition of Response Surfaces, Mixtures, and Ridge Analyses, providing timely new techniques, new exercises, and expanded material. A comprehensive introduction to building empirical models, this book presents the general philosophy and computational details of a number of important topics, including factorial designs at two levels; fitting first and second-order models; adequacy of estimation and the use of transformation; and occurrence and elucidation of ridge systems. Substantially rewritten, the Second Edition reflects the emergence of ridge analysis of second-order response surfaces as a very practical tool that can be easily applied in a variety of circumstances. This unique, fully developed coverage of ridge analysis—a technique for exploring quadratic response surfaces including surfaces in the space of mixture ingredients and/or subject to linear restrictions—includes MINITAB® routines for performing the calculations for any number of dimensions. Many additional figures are included in the new edition, and new exercises (many based on data from published papers) offer insight into the methods used. The exercises and their solutions provide a variety of supplementary examples of response surface use, forming an extremely important component of the text. Response Surfaces, Mixtures, and Ridge Analyses, Second Edition presents material in a logical and understandable arrangement and includes six new chapters covering an up-to-date presentation of standard ridge analysis (without restrictions); design and analysis of mixtures experiments; ridge analysis methods when there are linear restrictions in the experimental space including the mixtures experiments case, with or without further linear restrictions; and canonical reduction of second-order response surfaces in the foregoing general case. Additional features in the new edition include: New exercises with worked answers added throughout An extensive revision of Chapter 5: Blocking and Fractionating 2k Designs Additional discussion on the projection of two-level designs into lower dimensional spaces This is an ideal reference for researchers as well as a primary text for Response Surface Methodology graduate-level courses and a supplementary text for Design of Experiments courses at the upper-undergraduate and beginning-graduate levels.
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