It has been over 50 years since Hans Selye formulated his concept of stress. This came after the isolation of epinephrine and norepinephrine and after the sympathetic system was associated with Walter Cannon's "fight or flight" response. The intervening years have witnessed a number of dis coveries that have furthered our understanding of the mechanisms of the stress response. The isolation, identification and manufacture of gluco corticoids, the identification and synthesis of ACTH and vasopressin, and the demonstration of hypothalamic regulation of ACTH secretion were pivotal discoveries. The recent identification and synthesis of CRR by Willie Vale and his colleagues gave new impetus to stress research. Several new concepts of stress have developed as a result of advances in bench research. These include the concept of an integrated "stress sys tem", the realization that there are bi-directional effects between stress and the immune system, the suggestion that a number of common psychiatric disorders represent dysregulation of systems responding to stress, and the epidemiologic association of stress with the major scourges of humanity.
Scottish Puritanism, 1590-1638, is a portrait of Protestantism in the two generations leading to the National Covenant of 1638. This book investigates the construction of a puritan community embracing 'godly' ministers along with significant numbers of lay men and women willing to engage in the practice of a piety which confronted the inner person and the external world, seeking the reformation of both. Topics include attitudes towards the Bible and the sacraments, the nature of the Christian life, the place of the feminine in Scottish divinity, and the development of ideas about predestination, covenanting, and the relationship between church and state. The book addresses the tensions inherent in puritanism, such as those associated with the nature of the church and the extent of freedom, and provides a perspective on the relationship between Scottish and English religious developments.
SAP can help you capture better information and deliver it more quickly, allowing you to make better decisions and maximize the business value of everything you do. However, SAP implementations require massive effort, total buy-in, and significant change throughout the organization. In SAP Implementation Unleashed, 10 expert SAP project managers, functional consultants, and technologists guide you through the entire journey, helping you avoid pain and pitfalls and gain all the benefits of SAP. The authors introduce start-to-finish business, technical, and project management roadmaps for successful SAP implementation. Then, drawing on their immense experience, they walk you through the entire process of planning and deployment—addressing make-or-break issues and hidden gaps that other guidebooks ignore. You’ll discover how to employ processes, models, and toolsets that help you achieve implementation excellence while systematically reducing cost and business risk. Along the way, you’ll find actionable advice and real-world insight into innovative project management, best-suited leadership, effective load testing, contemporary infrastructure implementation, and more. George W. Anderson is responsible for providing enterprise applications thought leadership for the EDS/HP office of the CTO. A long-time SAP consultant and PMI-certified project manager, George has authored several best-selling books and enjoys new challenges. Charles D. Nilson is a senior program manager for EDS/HP and has led many successful SAP implementation teams over the years. He is a PMI PMP and is SAP Partner Academy certified in MM and PP. Tim Rhodes is a senior SAP technical consultant for EDS/HP and a Basis/infrastructure veteran focused on implementing, migrating, and upgrading SAP Business Suite and NetWeaver solutions. Tim is also an SAP-certified technical consultant, OCP, MCSE, and HP Master ASE. Detailed Information on How To... Define the business vision driving your implementation, and use it to design your solution Use TCO techniques to fully understand SAP’s financial impact in your organization Structure your SAP project management office, business teams, technical support organization, and overall project team Size, plan, and test your SAP infrastructure to deliver the best performance and availability at the best cost Integrate SAP into an SOA environment Install and configure SAP Business Suite and NetWeaver components Perform basic functional configuration, testing, and change management activities Enable a smooth transition by successfully performing the critical tasks that immediately precede SAP Go-Live Choose the right mix of tools and applications to test, manage, and monitor SAP Prepare your SAP Operations team for its post-implementation responsibilities
This practical volume does not intend to replace a mentor, but acts as a readily accessible guide to the basic tools of lithic analysis. The book was awarded the 2005 SAA Award for Excellence in Archaeological Analysis. Some focuses of the manual include: history of stone tool research; procurement, manufacture and function; assemblage variability. It is an incomparable source for academic archaeologists, cultural resource and heritage management archaeologists, government heritage agencies, and upper-level undergraduate and graduate students of archaeology focused on the prehistoric period.
This book brings together leading scholars from diverse theological perspectives to reflect on various theological and practical aspects of the core Christian doctrine of the Trinity. Throughout, the contributors highlight the trinitarian shape of spiritual formation. The esteemed lineup of contributors includes Alister McGrath; Ellen T. Charry; Avery Cardinal Dulles, SJ; Frederica Mathewes-Green; J. I. Packer; James Earl Massey; Gerald L. Bray; Cornelius Plantinga Jr.; and Timothy George. This book will appeal to students, church leaders, and interested laity. It is the second book in the Beeson Divinity Studies series.
Our book addresses the needs of practitioners, engineers, scientists, regulators, resource managers, planners, and others with a need to know about septic systems. It arose after discussions about the need for a text that integrated current understanding of the hydrologic, physical, chemical, and biological processes involved in the treatment of wastewater using soil. In our experience, people working with septic systems – ourselves included – have a fragmented understanding of what these systems are, how they function, how wastewater moves through soil, how and which pollutants are removed, and how these systems impact the environment and public health. The relevant information is scattered across disciplines, information sources and audiences. This book is an attempt to collect and integrate this information in one place, and provide a scientific framework for understanding soil-based wastewater treatment.
Are policymakers capable of learning about the complex international environment they must deal with when formulating foreign policy? Interest in the phenomenon of "learning" has been growing, driven in part by the advent of Gorbachev, and by prospects for ending the Cold War. In this book, leading scholars explore the theoretical and practical imp
This book provides a comprehensive introduction to the principles and practice of book-keeping and accounting. Throughout the text, real-life case studies are used to illustrate principles. There are many practical exercises (with answers) and activities included. A section of GCSE questions is given at the end of the book.
A comprehensive, must-have handbook of matrix methods with a unique emphasis on statistical applications This timely book, A Matrix Handbook for Statisticians, provides a comprehensive, encyclopedic treatment of matrices as they relate to both statistical concepts and methodologies. Written by an experienced authority on matrices and statistical theory, this handbook is organized by topic rather than mathematical developments and includes numerous references to both the theory behind the methods and the applications of the methods. A uniform approach is applied to each chapter, which contains four parts: a definition followed by a list of results; a short list of references to related topics in the book; one or more references to proofs; and references to applications. The use of extensive cross-referencing to topics within the book and external referencing to proofs allows for definitions to be located easily as well as interrelationships among subject areas to be recognized. A Matrix Handbook for Statisticians addresses the need for matrix theory topics to be presented together in one book and features a collection of topics not found elsewhere under one cover. These topics include: Complex matrices A wide range of special matrices and their properties Special products and operators, such as the Kronecker product Partitioned and patterned matrices Matrix analysis and approximation Matrix optimization Majorization Random vectors and matrices Inequalities, such as probabilistic inequalities Additional topics, such as rank, eigenvalues, determinants, norms, generalized inverses, linear and quadratic equations, differentiation, and Jacobians, are also included. The book assumes a fundamental knowledge of vectors and matrices, maintains a reasonable level of abstraction when appropriate, and provides a comprehensive compendium of linear algebra results with use or potential use in statistics. A Matrix Handbook for Statisticians is an essential, one-of-a-kind book for graduate-level courses in advanced statistical studies including linear and nonlinear models, multivariate analysis, and statistical computing. It also serves as an excellent self-study guide for statistical researchers.
This book was written to familiarize beginners with general theoretical principles, requirements, applications, and processing steps of the Eddy Covariance method. It is intended to assist in further understanding the method, and provides references such as textbooks, network guidelines and journal papers. It is also intended to help students and researchers in field deployment of instruments used with the Eddy Covariance method, and to promote its use beyond micrometeorology.
This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.
This comprehensive text aims to provide students with the information, strategies & motivation they need to help themselves improve the way they look, feel & perform.
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