So Near Yet So Far provides in-depth look at the multiple dimensions of Canada–US relations, particularly since 9/11. Based on almost 200 interviews with government policy makers, opinion-shapers, and interest group leaders in both countries, this book considers the interaction of domestic and cross-border politics at several levels, including political-strategic, trade-commercial, cultural-psychological, and institutional-procedural. It will appeal to practitioners, scholars, and citizens of both countries who want a better understanding of how the Canada–US relationship works – and can be made to work more effectively. Balanced and fair, it gets to the core issues without distorting perspectives on either side of the border.
THINK Currency. THINK Issues. THINK Relevancy. THINK Sociology. With an engaging visual design and just 15 chapters, THINK Sociology is the Australian Sociology text your students will want to read. This text thinks their thoughts, speaks their language, grapples with the current-day problems they face, and grounds sociology in real world experiences. THINK Sociology is informed with the latest research and the most contemporary examples, allowing you to bring current events directly into your unit with little additional work.
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
Geoffrey Walford, a renowned and experienced researcher, reflects upon the trials and tribulations and the problems and promises of conducting research - and also on the links between the idiosyncrasies and circumstances of researchers and what is possible in research. Research is revealed as a much more complicated process than is usually recognized, sometimes messy and disorganized, sometimes constrained in unexpected ways, but always challenging to both researcher and reader.
Tumour markers are molecules occurring in blood or tissue that are associated with cancer, and whose measurement or identification is useful in patient diagnosis or clinical management. This book analyses potential signals of cancerous tumours, otherwise known as markers or indicators. This includes, direct and rapid determination of cancer antigen, potential tumour markers for cholangiocarcinoma, melanoma inhibitory activity, metastatic uveal melanoma, measurement of tumour oxygenation, bladder cancer markers, epithelial cell adhesion and progression markers in prostate tumours.
Fear and terror have come to drive world politics, and the people who do the driving have shaped and used them to carry out their policies. As the world's political economy devolves into chaos, Globalization of American Fear Culture posits that violence and fear have become the new statecraft.
Rev. ed. of: Pediatric cerebrovascular disorders / E.S. Roach, Anthony R. Riela; with a foreword by Roger N. Rosenberg; chapters by Susan T. Iannaccone and Jeffrey Perlman. 1995. 2nd ed.
A revealing and surprising look at how classification systems can shape both worldviews and social interactions. What do a seventeenth-century mortality table (whose causes of death include "fainted in a bath," "frighted," and "itch"); the identification of South Africans during apartheid as European, Asian, colored, or black; and the separation of machine- from hand-washables have in common? All are examples of classification—the scaffolding of information infrastructures. In Sorting Things Out, Geoffrey C. Bowker and Susan Leigh Star explore the role of categories and standards in shaping the modern world. In a clear and lively style, they investigate a variety of classification systems, including the International Classification of Diseases, the Nursing Interventions Classification, race classification under apartheid in South Africa, and the classification of viruses and of tuberculosis. The authors emphasize the role of invisibility in the process by which classification orders human interaction. They examine how categories are made and kept invisible, and how people can change this invisibility when necessary. They also explore systems of classification as part of the built information environment. Much as an urban historian would review highway permits and zoning decisions to tell a city's story, the authors review archives of classification design to understand how decisions have been made. Sorting Things Out has a moral agenda, for each standard and category valorizes some point of view and silences another. Standards and classifications produce advantage or suffering. Jobs are made and lost; some regions benefit at the expense of others. How these choices are made and how we think about that process are at the moral and political core of this work. The book is an important empirical source for understanding the building of information infrastructures.
Leading orthopaedic surgeons and specialists collaborated to provide this multidisciplinary perspective on musculoskeletal tumors. From the experience and insight of these health professionals, Orthopaedic Knowledge Update®: Musculoskeletal Tumors 4 offers a big-picture view of the latest innovations in tumor care and optimized treatment. This fourth edition reflects the recent cutting-edge research and understanding of the molecular basis of neoplastic disease and new treatment options.
The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. "For both applied and theoretical statisticians as well as investigators working in the many areas in which relevant use can be made of discriminant techniques, this monograph provides a modern, comprehensive, and systematic account of discriminant analysis, with the focus on the more recent advances in the field." –SciTech Book News ". . . a very useful source of information for any researcher working in discriminant analysis and pattern recognition." –Computational Statistics Discriminant Analysis and Statistical Pattern Recognition provides a systematic account of the subject. While the focus is on practical considerations, both theoretical and practical issues are explored. Among the advances covered are regularized discriminant analysis and bootstrap-based assessment of the performance of a sample-based discriminant rule, and extensions of discriminant analysis motivated by problems in statistical image analysis. The accompanying bibliography contains over 1,200 references.
The new third edition of Pediatric Stroke and Cerebrovascular Disorders provides a modern clinical approach to managing stroke and other cerebrovascular problems in infants, children, and adolescents. Incorporating data from important clinical trials and case series, recommendations from the American Heart Association evidence-based paper on the management of pediatric stroke, and the latest information on new diagnostic techniques, the book offers a comprehensive analysis of the current thinking and practice by three physicians who have vast clinical experience in this challenging field. The third edition of this classic work has been completely updated and rewritten to reflect current science and practice. Covering occurrence, etiology, diagnosis, and treatment, this integrated state-of-the-art text is essential reading for anyone involved in the care of children with suspected stroke or other cerebrovascular abnormalities. The third edition of this classic work has been completely updated and rewritten to reflect current science and practice. An extensive, entirely new chapter on treatment provides specific guidance on when to use antiplatelet agents, anticoagulants, and thrombolytic agents in children and also includes a section on neurorehabilitation after stroke. An expanded and thoroughly updated diagnostic approach chapter covers the latest applications in stroke imaging such as computed tomography angiography, diffusion weighted MRI, and perfusion CT. The first chapter stresses the etiology and pathophysiology of childhood stroke as the basis for evaluations and treatment. Features of Pediatric Stroke and Cerebrovascular Disorders, Third Edition Include: Comprehensive in scope: detailed analysis of the pathogenesis, diagnosis, and treatment of cerebrovascular disorders in children with many evidence-based management guidelines The third edition has been updated to include recommendations from the AHA consensus guidelines All chapters in the third edition have been revised and updated An extensive, entirely new chapter on treatment provides specific guidance on when to use antiplatelet agents, anticoagulants, and thrombolytic agents in children Stresses the etiology and pathophysiology of childhood stroke as the basis for evaluation and treatment Maintains the practical, clinical flavor established in previous editions, with numerous illustrations and useful suggestions for patient care Written by internationally known stroke experts: Dr. Roach chaired the AHA panel that produced the consensus guidelines on childhood stroke and Drs. Lo and Heyer have published extensively on stroke and related topics
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