A distillation of sixty-seven of the best and most important plates from the original three volumes of the bestselling of the Historical Atlas of Canada.
A sweeping historical account of the Later Roman Empire incorporating the latest scholarly research In the newly revised 3rd edition of A History of the Later Roman Empire, 284-700, distinguished historians Geoffrey Greatrex and Stephen Mitchell deliver a thoroughly up-to-date discussion of the Later Roman Empire. It includes tables of information, numerous illustrations, maps, and chronological overviews. As the only single volume covering Late Antiquity and the early Islamic period, the book is designed as a comprehensive historical handbook covering the entire span between the Roman Empire to the Islamic conquests. The third edition is a significant expansion of the second edition—published in 2015—and includes two new chapters covering the seventh century. The rest of the work has been updated and revised, providing readers with a sweeping historical survey of the struggles, triumphs, and disasters of the Roman Empire, from the accession of the emperor Diocletian in AD 284 to the closing years of the seventh century. It also offers: A thorough description of the massive political and military transformations in Rome’s western and eastern empires Comprehensive explorations of the latest research on the Later Roman Empire Practical discussions of the tumultuous period ushered in by the Arab conquests Extensive updates, revisions, and corrections of the second edition Perfect for undergraduate and postgraduate students of ancient, medieval, early European, and Near Eastern history, A History of the Later Roman Empire, 284-700 will also benefit lay readers with an interest in the relevant historical period and students taking a survey course involving the late Roman Empire.
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
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