Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
This book provides an extended analysis of how resource extraction projects stimulate social, cultural and economic change in indigenous communities. Through a range of case studies, including open cast mining, artisanal mining, logging, deforestation, oil extraction and industrial fishing, the contributors explore the challenges highlighted in global debates on sustainability, Corporate Social Responsibility (CSR), and climate change. The case studies are used to assess whether and how development processes might compete and conflict with the market objectives of multinational corporations and the organizational and moral principles of indigenous communities. Emphasizing the perspectives of directly-affected parties, the authors identify common patterns in the way in which extraction projects are conceptualized, implemented and perceived. The book provides a deeper understanding of the dynamics of the human environments where resource extraction takes place and its consequent impacts on local livelihoods. Its in-depth case studies underscore the need for increased social accountability in the planning and development of natural resource extraction projects.
This book presents the first single comprehensive analysis of the scope of geographical realities and relevance in health care work. Conceptually, the book conveys how space, place and geographical ideas matter to clinical practice, from the historical beginnings of professional roles and responsibilities in medicine to the present day. In 8 chapters, the book covers healthcare work across a range of job types (including physician, nurse, and multiple technical and therapeutic roles in multiple specialties), and across a range of scales (focusing on global issues and trends, national and regional particularities, urban and rural issues, institutional environments and various community settings). This book is intended for students, teachers, and researchers in geography, social science and various health sciences. Chapter 1 examines how geographical ideas have been central to practitioners' thinking and practice over time. Chapter 2 reviews the scope of contemporary geographical study of health care work. Chapter 3 presents an empirical case study of the geographies in hospital-based ward work. Chapter 4 presents an empirical case study of the geographies in ambulance/rapid response work. Chapter 5 presents a case study of the geographies associated with a high profile case of criminality and neglect in practice. Chapter 6 considers concepts and the geographies in person-centred care. Chapter 7 considers concepts and the geographies in skills attainment.
Best selling author, award winning comedian and international keynote speaker Gavin Oattes challenges you to live life better than you have to, to never be afraid of your own style and to blow your own god damn mind for a change. Cast your mind back to that album that changed your life? The riffs, the hooks and the lyrics that blew your mind? That movie that moved your whole world and assured you that life was going to be special? Transporting you to a place you’d never been before, the opening chapter of that book that changed your life forever? The hairs on the back of your neck stood, adrenaline rushed through your entire body with the weight of the world gone from your young shoulders. Energised, inspired, alive, all in and ready to turn up to this wonderfully f*cked up thing we call life. Close your eyes and remember that feeling right there in that moment? Life Will See You Now is a rousing, uplifting anthem that will inspire you to put down your phone, rediscover what truly matters and completely rethink what ‘making it’ in life actually means. A personal development title with a difference – there’s no step-by-step guide and no map to change your life – instead, it provides you with hilarious, real life inspiration, motivation and energy to figure it out for yourself and rediscover that wee piece of magic you had when you were just five years old. Oattes makes the argument – backed by both positive psychology and an abundance of childlike wonder – that in an anxious world ruled by pressure, ego and other people’s expectations, we are all incredibly lucky to be alive at a time where kindness, gratitude, play and ice-lollies really do matter. Remember, you don't have to do what everyone else is doing. . .
Welcome to life. Teenage life. The most awkward 7 years you’ll ever have; 84 months of change, 364 weeks of weird and 2,555 days of scrolling and inconvenience. In the grand scheme of life, it’s not a lot. Unless you’re an actual teenager, in which case, it’s EVERYTHING! “It’s the best years of your life!” they tell us. And yet, while it should be, for so many it just doesn’t feel like it. For most it’s an emotional assault course of acceptance, stress, anxiety, heartbreak and peer pressure, all whilst navigating the ‘hashtagony’ of social media. Misunderstood by society and misrepresented by the media, teenagers have it tough. A Head Full of Everything demonstrates that being a teenager doesn’t have to suck. And when it does, there’s some cool things you can do to make it suck a little less. This book will challenge you to embrace your inner weird, to never grow up, be true to yourself, protect your mental health and be sure that for your 7 glorious teenage years, you act your age. Literally. Bestselling author, award-winning comedian and international keynote speaker, Gavin Oattes has written a personal development title for teens with a difference – there’s no waffle, no dad chat, no fluff. Full of hilarious, real-life inspiration and a few crazy ideas along the way, A Head Full of Everything will leave you feeling motivated, energised and reassured that nobody has life all figured out.
Crumbling business models mean news media structures must change. Gavin Ellis explores the past and present use of newspaper trusts – drawing on case studies such as the Guardian, the Irish Times and the Pulitzer Prize winning Tampa Bay Times – to make the case for a form of ownership dedicated to sustaining high quality journalism.
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