Written by leading experts, 'Fast Facts: Clinical Trials in Oncology' will enhance the reader’s ability to critically evaluate published evidence. Assuming little or no prior knowledge, the book sets out clearly the fundamental features of clinical trials. The key attributes of Phase I–III trials of pharmaceutical products are described, as are trials of surgical procedures, radiation therapy and advanced therapies. The processes and documentation required to set up and conduct a trial are outlined, and the authors describe how trial data and real-world evidence are used to improve care. Although this concise colorful book focuses on oncology, the principles apply equally to interventions in other areas of practice. It will prove invaluable to medical, pharmaceutical and allied health professionals who want, or need, an overview of how contemporary clinical trials are designed and conducted. Contents: • Fundamental features of clinical trials • Phase I trials • Phase II trials • Phase III trials • Trials of non-drug interventions • Setting up and conducting trials • Publishing trial results, changing clinical practice, and supporting evidence
This volume attempts an objective reassessment of the controversial works and life of American horror writer H. P. Lovecraft. Ignoring secondary accounts and various received truths, Gavin Callaghan goes back to the weird texts themselves, and follows where Lovecraft leads him: into an arcane world of parental giganticism and inverted classicism, in which Lovecraft's parental obsessions were twisted into the all-powerful cosmic monsters of his imaginary cosmology.
After considering the aging population in developed countries, it has become clear to physicians and public policy administrators that prevention of cancer must play a more important role in national anti-cancer policy than it has in the past. The recent introduction of an HPV vaccine, coupled with discoveries concerning the relationship of H. pylori and cancer has brought the role of infectious agents in cancer into sharp focus in the medical community. While interest in the subject has grown, no single source existed to bring clinicians up-to-date on developments in disease mechanisms, population-based risk assessment and policy considerations in the field of cancer prevention. In this current and comprehensive text the authors review the basic science and clinical implications of individual infectious agents, while going beyond a mere update of the literature to offer insights on the current emerging prevention possibilities. This prevention perspective is what makes this particular text so valuable to researchers, epidemiologists, health care policy makers and oncologists. The discussion is organized to highlight the vital role of primary cancer prevention, and suggest directions for future research, practice and policy. Since HPV continues to be at the center of interest in the arena of infectious agents and cancer, the authors frame the majority of their discussion on this now-famous virus. The sheer volume of literature related to this virus and its many related cancers, and the burgeoning research on the development and implementation of a prophylactic vaccine necessitates a much fuller review of this infectious agent. Therefore, the book is roughly divided into two equal parts: one part devoted to HPV and another part devoted to five other prominent infectious agents in cancer.
Horses played a major role in the military, economic, social and cultural history of early-modern England. This book uses the supply of horses to parliamentary armies during the English Civil War to make two related points. Firstly it shows how control of resources - although vital to success - is contingent upon a variety of logistical and political considerations. It then demonstrates how competition for resources and construction of individuals’ identities and allegiances fed into each other. Resources, such as horses, did not automatically flow out of areas which were nominally under Parliament’s control. Parliament had to construct administrative systems and make them work. This was not easy when only a minority of the population actively supported either side and property rights had to be negotiated, so the success of these negotiations was never a foregone conclusion. The study also demonstrates how competition for resources and construction of identities fed into each other. It argues that allegiance was not a fixed underlying condition, but was something external and changeable. Actions were more important than thoughts and to secure victory, both sides needed people to do things rather than feel vaguely sympathetic. Furthermore, identities were not always self-fashioned but could be imposed on people against their will, making them liable to disarmament, sequestration, fines or imprisonment. More than simply a book about resources and logistics, this study poses fundamental questions of identity construction, showing how culture and reality influence each other. Through an exploration of Parliament’s interaction with local communities and individuals, it reveals fascinating intersections between military necessity and issues of gender, patriarchy, religion, bureaucracy, nationalism and allegiance.
The Cult of the Modern focuses on nineteenth-century France and Algeria and examines the role that ideas of modernity and modernization played in both national and colonial programs during the years of the Second Empire and the early Third Republic. Gavin Murray-Miller rethinks the subject by examining the idiomatic use of modernity in French cultural and political discourse. The Cult of the Modern argues that the modern French republic is a product of nineteenth-century colonialism rather than a creation of the Enlightenment or the French Revolution. This analysis contests the predominant Parisian and metropolitan contexts that have traditionally framed French modernity studies, noting the important role that colonial Algeria and the administration of Muslim subjects played in shaping understandings of modern identity and governance among nineteenth-century politicians and intellectuals. In synthesizing the narratives of continental France and colonial North Africa, Murray-Miller proposes a new framework for nineteenth-century French political and cultural history, bringing into sharp relief the diverse ways in which the French nation was imagined and represented throughout the country’s turbulent postrevolutionary history, as well as the implications for prevailing understandings of France today.
Tropicality is a centuries-old Western discourse that treats otherness and the exotic in binary – ‘us’ and ‘them’ – terms. It has long been implicated in empire and its anxieties over difference. However, little attention has been paid to its twentieth-century genealogy. This book explores this neglected history through the work of Pierre Gourou, one of the century’s foremost purveyors of what anti-colonial writer Aimé Césaire dubbed tropicalité. It explores how Gourou’s interpretations of ‘the nature’ of the tropical world, and its innate difference from the temperate world, were built on the shifting sands of twentieth-century history – empire and freedom, modernity and disenchantment, war and revolution, culture and civilisation, and race and development. The book addresses key questions about the location and power of knowledge by focusing on Gourou’s cultivation of the tropics as a romanticised, networked and affective domain. The book probes what Césaire described as Gourou’s ‘impure and worldly geography’ as a way of opening up interdisciplinary questions of geography, ontology, epistemology, experience and materiality. This book will be of great interest to scholars and students within historical geography, history, postcolonial studies, cultural studies and international relations.
BMX bikes are iconic. There’s something about them that appeals to kids, adults and cyclists. And, of course, BMX is now an Olympic sport. Rad Rides is the most in-depth exploration of the world of BMX bikes through their riders and the culture that surrounds them. The introduction explains and contextualizes the birth of BMX culture and where it is now, while the main body features bikes ranging from those that are well-worn through years of riding to beautiful, sculptural works of art – gleaming, built-but-never-ridden keepsakes. The featured bikes are organized decade by decade and are BMXs drawn from the best collections in the world. There are also in-depth details of specifications and interviews with some of the collectors, many of whom have had their bikes exclusively shot for the book. This is the indispensable companion for anyone who loves the BMX.
The Handbook of Human and Social Conditions in Assessment is the first book to explore assessment issues and opportunities occurring due to the real world of human, cultural, historical, and societal influences upon assessment practices, policies, and statistical modeling. With chapters written by experts in the field, this book engages with numerous forms of assessment: from classroom-level formative assessment practices to national accountability and international comparative testing practices all of which are significantly influenced by social and cultural conditions. A unique and timely contribution to the field of Educational Psychology, the Handbook of Human and Social Conditions in Assessment is written for researchers, educators, and policy makers interested in how social and human complexity affect assessment at all levels of learning. Organized into four sections, this volume examines assessment in relation to teachers, students, classroom conditions, and cultural factors. Each section is comprised of a series of chapters, followed by a discussant chapter that synthesizes key ideas and offers directions for future research. Taken together, the chapters in this volume demonstrate that teachers, test creators, and policy makers must account for the human and social conditions that shape assessment if they are to implement successful assessment practices which accomplish their intended outcomes.
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