A practical guide to all key the elements of pharmaceuticals and biotech manufacturing and design Engineers working in the pharmaceutical and biotech industries are routinely called upon to handle operational issues outside of their fields of expertise. Traditionally the competencies required to fulfill those tasks were achieved piecemeal, through years of self-teaching and on-the-job experience—until now. Practical Pharmaceutical Engineering provides readers with the technical information and tools needed to deal with most common engineering issues that can arise in the course of day-to-day operations of pharmaceutical/biotech research and manufacturing. Engineers working in pharma/biotech wear many hats. They are involved in the conception, design, construction, and operation of research facilities and manufacturing plants, as well as the scale-up, manufacturing, packaging, and labeling processes. They have to implement FDA regulations, validation assurance, quality control, and Good Manufacturing Practices (GMP) compliance measures, and to maintain a high level of personal and environmental safety. This book provides readers from a range of engineering specialties with a detailed blueprint and the technical knowledge needed to tackle those critical responsibilities with confidence. At minimum, after reading this book, readers will have the knowledge needed to constructively participate in contractor/user briefings. Provides pharmaceutical industry professionals with an overview of how all the parts fit together and a level of expertise that can take years of on-the-job experience to acquire Addresses topics not covered in university courses but which are crucial to working effectively in the pharma/biotech industry Fills a gap in the literature, providing important information on pharmaceutical operation issues required for meeting regulatory guidelines, plant support design, and project engineering Covers the basics of HVAC systems, water systems, electric systems, reliability, maintainability, and quality assurance, relevant to pharmaceutical engineering Practical Pharmaceutical Engineering is an indispensable “tool of the trade” for chemical engineers, mechanical engineers, and pharmaceutical engineers employed by pharmaceutical and biotech companies, engineering firms, and consulting firms. It also is a must-read for engineering students, pharmacy students, chemistry students, and others considering a career in pharmaceuticals.
Manufacturing Possibilities examines adjustment dynamics in the steel, automobile and machinery industries in Germany, the U.S., and Japan since World War II. As national industrial actors in each sector try to compete in global markets, the book argues that they recompose firm and industry boundaries, stakeholder identities and interests, and governance mechanisms at all levels of their political economies. Micro level study of industrial transformation in this way provides a significant window on macro level processes of political economic change in the three societies. Theoretically, the book marks a departure from both neoliberal economic and historical institutionalist perspectives on change in advanced political economies. It characterizes industrial change as a creative, bottom-up process driven by reflective social actors. This alternative view consists of two distinctive claims. The first is that action is social, reflective, and ultimately creative. When their interactive habits are disrupted, industrial actors seek to repair their relations by reconceiving them. Such imaginative interaction redefines interest and causes unforeseen possibilities for action to emerge, enabling actors to trump existing rules and constraints. Second, industrial change driven by creative action is recompositional. In the social process of reflection, actors rearrange, modify, reconceive, and reposition inherited organizational forms and governance mechanisms as they experiment with solutions to the challenges that they face. Continuity in relations is interwoven with continuous reform and change. Most remarkably, creativity in the recomposition process makes the introduction of entirely new practices and relations possible. Ultimately, the message of Manufacturing Possibilities is that social study of change in advanced political economies should devote itself to the discovery of possibility. Preoccupation with constraint and failure to appreciate the capaciousness of reflective social action has led much of contemporary debate to misrecognize the dynamics of change. As a result, discussion of the range of adjustment possibilities in advanced political economies has been unnecessarily limited.
The ultimate reference guide to your fishing line and everything that goes on the end of it: hooks, sinkers, snaps, swivels, floats, leaders, lures, and knots.
In the wake of the Great Recession of 2008–09, economists feared that protectionist policies might sweep the world economy, echoing the wave of tariff escalations during the Great Depression of the 1930s. To some surprise, officials were more restrained and largely avoided traditional forms of protection (tariffs and quotas). As a result, economists underestimated the incidence of new protectionism because policymakers increasingly turned to more opaque behind-the-border nontariff barriers (NTBs). Using a combination of statistical analysis and case studies, the authors show that local content requirements (LCRs), a form of NTB, have become increasingly popular. How much was global trade actually reduced on account of LCRs? A conservative estimate might be $93 billion. Case studies featured cover the healthcare sector in Brazil, wind turbines in Canada, the automobile industry in China, solar cells and modules in India, oil and gas in Nigeria, and "Buy American" restrictions on government procurement.
To understand Construction Estimating one must also understand plan reading and construction techniques. This book is designed to teach the construction student these three core skills in equal measure. Using hundreds of plans, sketches, and photos, the book builds case studies of the major construction divisions including concrete, masonry, carpentry, and more. Over forty cases are divided into sections following a specially designed format: Plans: Scale drawings of floor plans, sections, or elevations. Plan Interpretation: The drawings are explained with comments. Scope of the Work: A written description of the boundaries of the work is given for each section. Construction Techniques: The construction processes and their sequence are explained. The Takeoff: A takeoff is shown at the end of each section. This approach helps foster confidence in plan reading, building methods, arithmetic, takeoffs, and estimates. The various products and terms used in the industries of structural steel, doors and hardware, and roofing are defined. The shop drawing process is explained, which is so important in many industries, as well as the role of and difference between manufacturers, fabricators, and suppliers/distributors. The book ends with a study of "front end" documents, including Division 00 General Conditions, AIA 201, and Division 01 General Requirements, and a chapter on Ethics. This textbook can be used to teach a variety of classes including plan reading, construction techniques, and estimating 1 and 2 (takeoffs and pricing).
The second edition of the book that provides a unique integrated analysis of Japan's social, political, and economic history from 1932 until the present day.
This book advocates a more thoughtful approach to urban water management. The approach involves reducing water consumption, harvesting rainwater, recycling rainwater and adopting Sustainable Drainage Systems (SuDS) where surface water is not sent straight to drains but is intercepted by features like green roofs, rain gardens, swales and ponds.Cities in particular need to change the existing linear model of water consumption and use to a more circular one in order to survive. The Water Sensitive City brings together the various specialised technical discussions that have been continuing for some time into a volume that is more accessible to designers (engineers and architects), urban planners and managers, and policymakers.
The only modern guide to all aspects of practical tunnel construction Practical Tunnel Construction fills a void in the literature for a practical guide to tunnel construction. By taking the reader through a brief introduction and history to a comprehensive discussion of how the geological factors affect tunneling, the author covers the stages and technology that are common today without using complex equations. Written for the individual who does not have an extensive background in tunneling but who has to make tunneling decisions, the various tunneling methods are discussed to help in the determination of the appropriate method. The methods discussed are: hand mining, drill/blast, Tunnel Boring Machine (TBM), New Austrian Tunnelling Method (NATM), Norwegian Method of Tunnelling (NMT), Roadheader, Earth Pressure Balance Machine (EPBM), and Slurry Pressure Balance Machine (SPBM). This book focuses on driven tunnels. This versatile handbook: Offers clear and accessible coverage of the state of the art in tunnel construction Introduces the essentials of design and construction of many types of tunnels, including TBM, EPB, Roadheader, NATM, drill and blast, and soft ground tunneling Provides nontechnical guidance on selecting the most appropriate tunneling methods for various situations Includes a brief history of tunneling and an introduction to geotechnical considerations Discusses tunnel access shaft construction, mucking methods, tunnel haulage, grout, water handling, and much more Practical Tunnel Construction is an important resource for students, construction managers, tunnel designers, municipal engineers, or engineers who are employed by government agencies or corporations that are exploring the feasibility of planning and designing or building a tunnel.
Analyzing Sraffa, one of the key figures in the history of economics, this book explores his legacy and the relevance of his thought for modern economics. Written by an array of internationally respected contributors, including Schefold, Aspromourgos, Nell and Kurz it is an invaluable tool for all those studying the history of economic thought.
The second edition of Dr. Gary A. Donaldson’s highly successful textbook The Making of Modern America, introduces students to the cultural, social and political paths the United States has traveled from the end of WWII to the present day.
Industrial policy is making a comeback in the United States. It is more urgent than ever to understand how and whether industrial policy has worked to strengthen the US economy. This study analyzes and scores 18 US industrial policy episodes implemented between 1970 and 2020, in an effort to assess what went right and what went wrong—and how the current initiatives might fare. The Peterson Institute for International Economics gratefully acknowledges the support of the Koch Foundation for this project.
This new edition of the Standard Handbook of Petroleum and Natural Gas Engineering provides you with the best, state-of-the-art coverage for every aspect of petroleum and natural gas engineering. With thousands of illustrations and 1,600 information-packed pages, this text is a handy and valuable reference. Written by over a dozen leading industry experts and academics, the Standard Handbook of Petroleum and Natural Gas Engineering provides the best, most comprehensive source of petroleum engineering information available. Now in an easy-to-use single volume format, this classic is one of the true "must haves" in any petroleum or natural gas engineer's library. - A classic for the oil and gas industry for over 65 years! - A comprehensive source for the newest developments, advances, and procedures in the petrochemical industry, covering everything from drilling and production to the economics of the oil patch - Everything you need - all the facts, data, equipment, performance, and principles of petroleum engineering, information not found anywhere else - A desktop reference for all kinds of calculations, tables, and equations that engineers need on the rig or in the office - A time and money saver on procedural and equipment alternatives, application techniques, and new approaches to problems
Industrial products that are made from, or contain, nitrogen are described in parts of some encyclopedias and standard reference works. However it is not always simple to determine from these varied sources the present status of the technology and markets for various nitrogen products. We therefore perceived a need for a text that provides a comprehensive description of: 1) products that are made from or that contain nitrogen; 2) the processes that produce these products; and 3) the markets that consume these products. I have attempted to present the material in a standardized format that should make this book easy to use and helpful to the readers. The standard format for each product is: Introduction, Process, Production, and Uses, with some variations in different chapters. This book provides information that could be used by a wide range of readers: Fertilizer companies—to evaluate different production processes and review general trends in the market. Basic chemical companies—to evaluate different production processes and review general trends in the market. Specialty chemical companies—to investigate new chemical production and/or sales opportunities and the processes that could make those sales a possibility. Chemical distributors—to obtain a feel for the general market size for some chemicals and the basic handling and distribution procedures for various chemicals. Engineering Companies—to evaluate different production processes and review general trends in the market. Engineering and Chemistry Students—to learn more about practical applications of the principals that they have experienced in their classrooms and laboratories.
Examines negotiation of the North American Free Trade Agreement. Analyses issues involved and provides policy recommendations through study of the potential impact and critical factors concerning trade, investment, labour, the environment, and intellectual property. Also covers the impact upon and adjustments required in major industrial sectors - energy, steel, automobiles, textiles and apparel, agriculture, and the financial system.
The accelerating cross-border flow of products, services, capital, ideas, technology and people is driving businesses--large and small--to internationalise. International Business 2nd Australasian edition: the New Realities is a rigorous resource which prepares future managers to operate successfully in multinational settings. Case studies from a wide variety of markets relevant to Australasian business, including ASEAN countries as well as China, India, Japan, South Korea, Pakistan, Europe and the Middle East, provide a real-world perspective to theories and examine the latest trends in international business. The second edition of International Business features 10 new in-depth case studies specially created for this edition. For undergraduate students majoring in international business or post-graduate courses in international business.
A Wall Street Journal Bestseller In a world of unrelenting change and unprecedented challenges, we need organizations that are resilient and daring. Unfortunately, most organizations, overburdened by bureaucracy, are sluggish and timid. In the age of upheaval, top-down power structures and rule-choked management systems are a liability. They crush creativity and stifle initiative. As leaders, employees, investors, and citizens, we deserve better. We need organizations that are bold, entrepreneurial, and as nimble as change itself. Hence this book. In Humanocracy, Gary Hamel and Michele Zanini make a passionate, data-driven argument for excising bureaucracy and replacing it with something better. Drawing on more than a decade of research and packed with practical examples, Humanocracy lays out a detailed blueprint for creating organizations that are as inspired and ingenious as the human beings inside them. Critical building blocks include: Motivation: Rallying colleagues to the challenge of busting bureaucracy Models: Leveraging the experience of organizations that have profitably challenged the bureaucratic status quo Mindsets: Escaping the industrial age thinking that frustrates progress Mobilization: Activating a pro-change coalition to hack outmoded management systems and processes Migration: Embedding the principles of humanocracy—ownership, markets, meritocracy, community, openness, experimentation, and paradox—in your organization's DNA If you've finally run out of patience with bureaucratic bullshit . . . If you want to build an organization that can outrun change . . . If you're committed to giving every team member the chance to learn, grow, and contribute . . . . . . then this book's for you. Whatever your role or title, Humanocracy will show you how to launch an unstoppable movement to equip and empower everyone in your organization to be their best and to do their best. The ultimate prize: an organization that's fit for the future and fit for human beings.
By examining important aspects of science fiction in the twentieth century, this book explains how the genre evolved to its current state. Close critical attention is given to topics including the art that has accompanied science fiction, the subgenres of space opera and hard science fiction, the rise of SF anthologies, and the burgeoning impact of the marketplace on authors. Included are in-depth studies of key texts that contributed to science fiction's growth, including Philip Francis Nowlan's first Buck Rogers story, the first published stories of A. E. van Vogt, and the early juveniles of Isaac Asimov, Arthur C. Clarke and Robert Heinlein.
This glossary provides a ready reference to those in the geosciences with the need to translate from English to Spanish or vice versa. It also provides clear communication, a better understanding, and closer working relationships among geoscientists, engineers, and businessmen.
Cambridge IGCSE and O Level Geography has been written specifically for Cambridge International syllabuses 0460 and 2217. Filled with sources, graphs and case studies, the coursebook requires students to examine a range of information, helping to build their analytical skills. Written by highly experienced authors and Cambridge trainers, this coursebook is updated to support both Cambridge IGCSE and O Level students. It includes clear and practical support, case studies from 25 different countries, fieldwork ideas and a range of interesting content. The accompanying CD-ROM contains support sheets for the topics covered, outline maps and sample exam-style questions. Answers to the activities are in the teacher's resource.
This quirky, brilliant book gives the reader the thrill of cultural history done well. Okihiro undertakes a conventional topic in a jarring way, avoiding the assumption of set boundaries of nations and human societies."—Henry Yu, author of Thinking Orientals: Migration, Contact, and Exoticism in Modern America "This beautifully written book integrates the history of Hawai'i into that of the U.S. better than any other I have ever read." —Patricia Seed, author of American Pentimento: The Invention of Indians and the Pursuit of Riches
International Civil Litigation in United States Courts, by Gary B. Born and Peter B. Rutledge, is the essential, comprehensive law school text for the current and future international litigator, whether based in the United States, Europe, or elsewhere. Examining every topic discussed in competing texts with extensive narrative, unparalleled notes, and detailed citations, this book covers the gamut of international dispute resolution, whether judicial jurisdiction, sovereign immunity, extraterritoriality, conflicts of law, parallel proceedings, discovery disputes, service, judgment enforcement, and international arbitration. This Seventh Edition includes excerpts and updated discussions of recent U.S. court decisions and legislation relating to a wide range of private and public international law topics. ,p>New to the Seventh Edition: Latest developments in litigation under the Alien Tort Statute and the Torture Victim Protection Act Latest developments in sovereign immunity law following several landmark Supreme Court decisions Latest developments regarding the extraterritorial application of federal law following several landmark Supreme Court decisions Critical examination of the new Restatement (Fourth) of the Foreign Relations of the United States Up-to-date citation and review of the most current academic legal scholarship in the field Professors and students will benefit from: Detailed notes with easy-to-use questions for discussion and legal analysis Comprehensive discussion of international dispute resolution, including international arbitration and other forms of dispute resolution outside of litigation in national courts Comparative foreign treatment of selected issues of international civil procedure Extensive notes and up-to-date citations that ensure the book has enduring value long after a course has ended, and it becomes a resource for practitioners seeking to research the field Documentary Supplement
For four decades, Petroleum Refining has guided thousands of readers toward a reliable understanding of the field, and through the years has become the standard text in many schools and universities around the world offering petroleum refining classes, for self-study, training, and as a reference for industry professionals. The sixth edition of this perennial bestseller continues in the tradition set by Jim Gary as the most modern and authoritative guide in the field. Updated and expanded to reflect new technologies, methods, and topics, the book includes new discussion on the business and economics of refining, cost estimation and complexity, crude origins and properties, fuel specifications, and updates on technology, process units, and catalysts. The first half of the book is written for a general audience to introduce the primary economic and market characteristics of the industry and to describe the inputs and outputs of refining. Most of this material is new to this edition and can be read independently or in parallel with the rest of the text. In the second half of the book, a technical review of the main process units of a refinery is provided, beginning with distillation and covering each of the primary conversion and treatment processes. Much of this material was reorganized, updated, and rewritten with greater emphasis on reaction chemistry and the role of catalysis in applications. Petroleum Refining: Technology, Economics, and Markets is a book written for users, the practitioners of refining, and all those who want to learn more about the field.
Before the interstates, Main Street America was the small town’s commercial spine and served as the linchpin for community social solidarity. Yet, during the past three decades, a series of economic downturns has left many of the great small cities barely viable. American Hometown Renewal is the first book to combine administrative, budgetary, and economic analysis to examine the economic and fiscal plight currently facing America’s small towns. Featuring a blend of theory, applications, and case studies, it provides a comprehensive, single-source textbook covering the key issues facing small town officials in today’s uncertain economy. Written by a former public manager, university professor, and consultant to numerous small towns in the Heartland, this book demonstrates the ways in which contemporary small towns throughout the nation are facing economic challenges brought about by the financial shocks that began in 2008. Each chapter explores a theme related to small town revival and provides a related tool or technique to enable small town officials to meet the challenges of the 21st Century. Encouraging local small town officials to look at the economic orbit of communities in a similar manner as a town’s budget or a family’s personal wealth, examining its specific competitive advantages in terms of relative assets to those of competing communities, this book provides the reader with step-by-step instructions on how to conduct an asset inventory and apply key asset tools to devise a strategy for overcoming the challenges and constraints imposed upon spatially-fixed communities. American Hometown Renewal is an essential primer for students studying city management, economic community development, and city planning, and will be a trusted handbook for city managers, geographers, city planners, urban or rural sociologists, political scientists, and regional microeconomists.
Expert advice for homeowners. Plumbing is often a mystery to most homeowners. As a result, faucets drip, toilets clog and pipes leak because of the hesitation to take on the repair project or call a plumber. Solving Home Plumbing Problems helps reluctant do-it-yourself homeowners understand and be successful with home plumbing jobs. Written in a jargon-free and accessible style, this handbook includes the most common situations plumbers are called in to fix. Illustrated with 80 color line drawings, the book covers: Plumbing tools Understanding the plumbing system Working with water pipes: copper/ plastic/steel Cutting and soldering pipe Maintaining drains Fixing common leaks Repairing all types of faucets Installing appliances and sprinkler systems Remodeling the bathroom Working with wells and septic tanks Repairing outdated plumbing fixtures Making quick fixes for minor emergencies Solving Home Plumbing Problems belongs on the bookshelf (or even better at the workbench) in every home.
This book is an eye-opening treatise on the fundamentals of the effects of radiation on metals and alloys. When energetic particles strike a solid, numerous processes occur that can change the physical and mechanical properties of the material. Metals and alloys represent an important class of materials that are subject to intense radiation fields. Radiation causes metals and alloys to swell, distort, blister, harden, soften and deform. This textbook and reference covers the basics of particle-atom interaction for a range of particle types, the amount and spatial extent of the resulting radiation damage, the physical effects of irradiation and the changes in mechanical behavior of irradiated metals and alloys.
From concept to application, this book describes the method of strain-range partitioning for analyzing time-dependent fatigue. Creep (time-dependent) deformation is first introduced for monotonic and cyclic loading. Multiple chapters then discuss strain-range partitioning in details for multi-axial loading conditions and how different loading permutations can lead to different micro-mechanistic effects. Notably, the total-strain method of strain-range partitioning (SRP) is described, which is a methodology that sees use in several industries. Examples from aerospace illustrate applications, and methods for predicting time-dependent metal fatigue are critiqued.
This is the most comprehensive, English-language study of the German Imperial Navy’s battlecruisers that served in the First World War. Known as Panzerkreuzer, literally “armored cruiser,” the eight ships of the class were to be involved in several early North Sea skirmishes before the great pitched battle of Jutland where they inflicted devastating damage on the Royal Navy’s battlecruiser fleet. This book details their design and construction, and traces the full service history of each ship, recounting their actions, drawing largely from first-hand German sources and official documents, many previously unpublished in English.
Fatigue and Durability of Structural Materials explains how mechanical material behavior relates to the design of structural machine components. The major emphasis is on fatigue and failure behavior using engineering models that have been developed to predict, in advance of service, acceptable fatigue and other durability-related lifetimes. The book covers broad classes of materials used for high-performance structural applications such as aerospace components, automobiles, and power generation systems. Coverage focuses on metallic materials but also addresses unique capabilities of important nonmetals. The concepts are applied to behavior at room or ambient temperatures; a planned second volume will address behavior at higher-temperatures. The volume is a repository of the most significant contributions by the authors to the art and science of material and structural durability over the past half century. During their careers, including 40 years of direct collaboration, they have developed a host of durability models that are based on sound physical and engineering principles. Yet, the models and interpretation of behavior have a unique simplicity that is appreciated by the practicing engineer as well as the beginning student. In addition to their own pioneering work, the authors also present the work of numerous others who have provided useful results that have moved progress in these fields. This book will be of immense value to practicing mechanical and materials engineers and designers charged with producing structural components with adequate durability. The coverage is appropriate for a range of technical levels from undergraduate engineering students through material behavior researchers and model developers. It will be of interest to personnel in the automotive and off-highway vehicle manufacturing industry, the aeronautical industry, space propulsion and the power generation/conversion industry, the electric power industry, the machine tool industry, and any industry associated with the design and manufacturing of mechanical equipment subject to cyclic loads.
The first of its kind, this modern, comprehensive text covers both analysis and design of piping systems. The authors begin with a review of basic hydraulic principles, with emphasis on their use in pumped pipelines, manifolds, and the analysis and design of large pipe networks. After the reader obtains an understanding of how these principles are implemented in computer solutions for steady state problems, the focus then turns to unsteady hydraulics. These are covered at three levels:
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