Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Massive thrombosis or bleeding, hereditary angioedema, Alzheimer''s disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.
This book discusses financing and documenting joint ventures and early-stage strategic partnerships; devising workable nondisclosure agreements and managing an intellectual property portfolio.
Groundbreaking cases in the American legal system. Through its interpretations of the Constitution and Bill of Rights, the Supreme Court issues decisions that shape American law, define the functioning of government and society,
First Published in 1990, this text brings together the work of several investigators who used in vitro techniques to probe the nature of embryonic cell response to a diverse group of chemical agents. It focuses on the approaches, limitations, usefulness and applicability of defining mechanisms underlying altered development. This work includes discussions on pharmacodynamic principles and placental transfer mechanisms. It also examines the potential for in vitro systems to serve as an adjunct to the risk assessment process. Ideal for both the layman and the expert in this area, this volume provides a general understanding of the types of approaches that can be used and specific approaches in investigating altered development.
British Columbia has one of the richest assemblages of bird species in the world. The four volumes of The Birds of British Columbia provide unprecedented coverage of this region's birds, presenting a wealth of information on the ornithological history, habitat, breeding habits, migratory movements, seasonality, and distribution patterns of each of the 472 species of birds. This third volume, covering the first half of the passerines, builds on the authoritative format of the previous bestselling volumes. It contains 89 species, including common ones such as swallows, jays, crows, wrens, thrushes, and starlings. The text is supported by hundreds of full-colour pictures, including unique habitat photographs, detailed distribution maps, and beautiful illustrations of the birds, their nests, eggs, and young. The Birds of British Columbia is a complete reference work for bird-watchers, ornithologists, and naturalists who want in-depth information on the province's regularly occurring and rare birds.
This manual examines 900 nonpublic US enterprises, including large industrial and service corporations like Milliken & Company and PricewaterhouseCoopers; hospitals and health-care organizations such as Blue Cross; charitable and membership organizations, including the Ford Foundation; mutual and co-operative organizations such as IGA; joint ventures such as Motiva; government-owned corporations such as the United States Postal Service; and major university systems, including The University of Texas System.
Enclosure marshals bold new and persuasive arguments about the ongoing dispossession of Palestinians. Revealing the Israel-Palestine landscape primarily as one of enclosure, geographer Gary Fields sheds fresh light on Israel's actions. He places those actions in historical context in a broad analysis of power and landscapes across the modern world. Examining the process of land-grabbing in early modern England, colonial North America, and contemporary Palestine, Enclosure shows how patterns of exclusion and privatization have emerged across time and geography. That the same moral, legal, and cartographic arguments were copied by enclosers of land in very different historical environments challenges Israel's current rationale as being uniquely beleaguered. It also helps readers in the United Kingdom and the United States understand the Israel-Palestine conflict in the context of their own, tortured histories"--Provided by publisher.
This book addresses how Christian leaders integrate faith into the workplace, through a love-based altruistic system of Christian Servant Leadership Spiritual Intelligence (CSLSI). It hypothesizes how CSLSI positively influences a range of desirable employee attitudes and behaviors including servant leadership and followership, organizational citizenship, and positive stress coping and adaptation strategies. This book embraces an interdisciplinary approach to present the global attributes of CSLSI, which includes following God’s will and Golden Rule workplace love expression, with specific workplace applications. The empirical research is supplemented by approximately 100 interviews with Christian leaders providing workplace exemplars and a compelling overview of how Christians honor God in the marketplace. This book will appeal to academics and practitioners in business, psychology, medicine, management, leadership, and theology looking to develop a God-honoring work life. Readers will benefit from the principles and the self-diagnostic surveys that assess spiritual intelligence and ways to enhance it.
This text is a go-to resource for those wanting to broaden their knowledge and critical understanding of how international education can be transformed in the future based on theory and research. The core focus of the book is to enable the reader to critically reflect on the role of education in a future global society where justice, equality, and renewal are central features. Each chapter explores an alternative approach to education, including: Approaches grounded in indigenous cultures and ancient wisdom traditions, as well as those from radical perspectives on the role of society and culture Reconsidered interpretations of current approaches based on critical theories and alternative ways of knowing and understanding Exploration of the role of technology in providing access to education in a world where learning moves beyond fixed locations and boundaries Reflection on current learning environments populated by new global communities. Aimed primarily at undergraduate students in education, Pedagogies for the Future also gives voice to new and ancient narratives of hope and renewal which are vital for postgraduate study and initial teacher education and training, as well as education policymakers.
Outsider Cops By: J. Gary Shaw The Caribbean Case was supposed to be an easy one for Chief Detective Curtis Cole and his partner Detective William Strong – solve eight suspicious deaths, plus assist two United States Drug Enforcement Agents to take down an international drug cartel. But it was not easy. They quickly discovered that the Palm Island Police Service would not help them. The Commissioner of Police was a greedy dictatorial, lying, despicable person who was coercing his staff and the public to facilitate an international drug cartel. Cole had to use every trick learned from years of experience to stay alive, and get the job done. Each day became a new challenge to find who to trust. As the window of opportunity started to close, he planned a historic raid. Detective Strong exclaimed, “This is war!” Sun, sea, sand, sex, and murder – the mission was not a holiday!
In the heart of London’s sprawling underground, DI Ryan McNally and DS Marcia Frost of the British Transport Police Major Investigations Team find themselves unravelling the threads of a cold case two decades old. The skeletal remains unearthed at Lambeth North station set the stage for a chilling narrative that plunges deep into the heart of unsolved murder. Just as the pieces seem to fall into place, a sinister new mystery unfurls. A string of female suicides across various underground locations emerges to be a mask for a darkly orchestrated series of murders. As McNally’s team delves deeper, the eerie connection between the cold case and the recent murders grows impossible to ignore. As McNally and Frost wade through the life stories of the victims, desperate to unearth the elusive link binding them, they find themselves spiralling closer to a deadly climax that threatens to engulf them whole. Mind the Killer offers a relentless narrative pace set against the backdrop of a unique policing environment that courses through the veins of London’s underground. With each chapter, shocking twists uncoil, leading to a jaw-dropping finale that reverberates through the very last sentence. The book isn’t just a tale of murder and intrigue, but a chilling journey into the core of fear and the unyielding grasp of vengeance.
This textbook is a second edition of Evolutionary Algorithms for Solving Multi-Objective Problems, significantly expanded and adapted for the classroom. The various features of multi-objective evolutionary algorithms are presented here in an innovative and student-friendly fashion, incorporating state-of-the-art research. The book disseminates the application of evolutionary algorithm techniques to a variety of practical problems. It contains exhaustive appendices, index and bibliography and links to a complete set of teaching tutorials, exercises and solutions.
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