This text atlas focuses on the pathology and molecular genetics of sudden cardiac death in the young and in athletes, presenting the state of the art in the field as the basis for development and implementation of more effective prevention strategies, including, ultimately, molecular therapy that will cure the underlying biological defect. A wealth of high-resolution color images, accompanied by clear supporting text, are presented to document the anatomic pathology of the cardiac diseases most frequently responsible for sudden cardiac death in this population, including coronary artery diseases, cardiomyopathies, myocarditis, valve diseases, conduction system abnormalities, congenital heart diseases, and ion channel diseases. The role of the molecular autopsy in overcoming the limitations of morphological investigations and offering new insights and avenues for prevention is explained. The approach is, however, interdisciplinary, with close attention also to epidemiologic and clinical aspects. The authors draw throughout on their experience gained over 30 years in the course of a prospective study carried out in the Veneto Region, North East Italy. This text atlas will be of great value not only for cardiologists but also for geneticists, sports physicians, and residents in cardiology and pathology.
This issue of Cardiac Electrophysiology Clinics covers arrhythmias in athletes, which can be a cause of morbidity and mortality. Expert authors review the most current information available about management of ventricular arrhythmias, atrial fibrillation, bradyarrhythmias, syncope and other conditions. Preparticipation screening, defibrillator use, and prevention are also discussed. Keep up-to-the-minute with the latest developments in this important aspect of cardiac electrophysiology practice.
Since Picketts failed charge at Gettysburg, the frontal infantry assault had been known as obsolete. Nevertheless fifty years later, Allied military leaders in the Great War persisted in using it as a military tactic. Italian military leaders were no exception not even accepting the deadly effect of machine guns or quick-firing artillery. The Battles of the Isonzo on the Austro-Italian Front have now been classified with Verdun as to intensity and casualty lists. Mountain warfare on the Isonzo River Valley resulted in almost two million casualties from avalanches, frostbite, malaria, cholera, as well as prisoner-of-war starvation. Using the attacco frontale the blood of the illiterate fanti was used as coin to purchase terrain pushing the enemy back leading to Vienna's request to Berlin for help, leading to Caporetto.
As noted in Volume I (The Beginning of Futility) after the Allies had induced Italy to join them against the Central Powers, the Italian Army used the lives of its illiterate peasant fanti as coin advancing to finally endanger Austro-Hungarian defenses. By August, 1917, Viennas generals were convinced that with German help they had to counterattack while Gen. Eric Ludendorff was wary of giving assistance. Finally he was won over after hearing a bold and daring plan later known as blitzkrieg. Italian Intelligence warnings of an enemy offensive were discarded as it was too late in the year. On October 24,1917, Austro-German forces unleashed the first blitzkrieg battle of the century which the Italian Army as the Anglo-French in France in May 1940 could not handle. Using the four commandments of blitzkrieg (deception, infiltration, isolation , annihilation), they quickly advanced 100 miles through the confused Italian defenses halting at the Piave River and adjacent mountains. Unable to handle the assault, many disheartened troops had fled, but later, with heroic deeds, halted the enemy advance. Notwithstanding the great victory, Vienna was negotiating a separate peace with Lloyd George and President Woodrow Wilson both of whom who did not believe the Allies could win.
The Beginning of Futility and Futility ending in Disaster discussed Italys joining the allies and going on the offensive against Austria-Hungary. With Berlins assistance deep penetrations were made into Italian territory resulting in allied troops coming to Italys assistance while secret negotiations for a separate peace with Vienna between U.S. President Wilson and Englands Prime Minister Lloyd George failed. A repeat Habsburg offensive was halted followed by the issuance of the Manifesto which would place the empires ethnics as independent nations under the Habsburg crown a move which led to the disintegration of the Habsburg Army and Empire.
Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. Chemotherapy of malignant neoplasms is also addressed. Special emphasis is given to clinico-pathologic correlations. With all chapters written by experts in their fields, this volume will serve as a useful resource for physicians dealing with, and interested in, this special branch of cardiac oncology and will represent a useful guide for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists as well as for postgraduate students training in these areas.
This text atlas focuses on the pathology and molecular genetics of sudden cardiac death in the young and in athletes, presenting the state of the art in the field as the basis for development and implementation of more effective prevention strategies, including, ultimately, molecular therapy that will cure the underlying biological defect. A wealth of high-resolution color images, accompanied by clear supporting text, are presented to document the anatomic pathology of the cardiac diseases most frequently responsible for sudden cardiac death in this population, including coronary artery diseases, cardiomyopathies, myocarditis, valve diseases, conduction system abnormalities, congenital heart diseases, and ion channel diseases. The role of the molecular autopsy in overcoming the limitations of morphological investigations and offering new insights and avenues for prevention is explained. The approach is, however, interdisciplinary, with close attention also to epidemiologic and clinical aspects. The authors draw throughout on their experience gained over 30 years in the course of a prospective study carried out in the Veneto Region, North East Italy. This text atlas will be of great value not only for cardiologists but also for geneticists, sports physicians, and residents in cardiology and pathology.
This issue of Cardiac Electrophysiology Clinics covers arrhythmias in athletes, which can be a cause of morbidity and mortality. Expert authors review the most current information available about management of ventricular arrhythmias, atrial fibrillation, bradyarrhythmias, syncope and other conditions. Preparticipation screening, defibrillator use, and prevention are also discussed. Keep up-to-the-minute with the latest developments in this important aspect of cardiac electrophysiology practice.
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