This monograph explains what economic analysis is, why it is important, and forms it can take in policing and criminal justice. Costs are important in all forms of economic analysis but their collection tends to be partial and inadequate in capturing key information. A practical guide to the collection is therefore also provided.
Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein’s Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases. An ideal balance of the basic science you need to know and how to apply that information to clinical practice. An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases. New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. More schematic diagrams clearly summarize information and facilitate understanding.
Graph algorithms is a well-established subject in mathematics and computer science. Beyond classical application fields, such as approximation, combinatorial optimization, graphics, and operations research, graph algorithms have recently attracted increased attention from computational molecular biology and computational chemistry. Centered around the fundamental issue of graph isomorphism, this text goes beyond classical graph problems of shortest paths, spanning trees, flows in networks, and matchings in bipartite graphs. Advanced algorithmic results and techniques of practical relevance are presented in a coherent and consolidated way. This book introduces graph algorithms on an intuitive basis followed by a detailed exposition in a literate programming style, with correctness proofs as well as worst-case analyses. Furthermore, full C++ implementations of all algorithms presented are given using the LEDA library of efficient data structures and algorithms.
With very few exceptions, eukaryotic cells possess two interdependent genomes, chromosomal and extra-chromosomal. Over the past several decades, cancer - search has focused primarily on deciphering the intricate alterations in the chro- somal genome, with until recently, very little attention to its cytoplasmic counterpart. In spite of the enormous complexity of the nuclear genome, which we now fully appreciate after completion of the human genome project, the efforts of cancer researchers are commendable in terms of the tremendous gains made in unraveling the numerous genetic changes in cancer. These changes include d- coveries of tumor suppressor genes, oncogenes, and caretaker genes that are often mutated in cancer. Recent studies of genomic pro?les are uncovering even more altered and mutated genes in cancer. Besides these ?ndings, several therapeutic targets for chemotherapy are currently made from studies of altered nuclear genetic pathways. Inspite of all these positive efforts, the war on cancer, declared in 1971 by Richard Nixon, is far from being worn. Indeed, the failure of chemotherapy is obvious to clinicians, oncologists, and their patients alike. Moreover, the global incidence and prevalence of cancer continue to rise. What are we missing? Which direction should we be taking? Of course, modern integrated nuclear genomics, proteomics, and metabolomics should provide important clues to carcinogenesis, but the contribution of cytoplasmic genetic alterations to carcinogenesis cannot be neglected.
Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rheumatology book’s sweeping updates highlight current advances and breakthroughs that impact your practice. With Kelley's Textbook of Rheumatology, you'll be ready to handle the toughest clinical challenges you face. Search the entire contents online at www.expertconsult.com, download all of images, and watch videos demonstrating the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints. Review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance with the integrated chapter format that readers of Kelley's Textbook of Rheumatology have always appreciated. Gain a thorough understanding of the "whys" and "hows" of rheumatic disease management with detailed coverage of the very latest breakthroughs and the newest clinical algorithms. Apply the latest therapeutic advances through new chapters in bioengineering and tissue engineering, as well as up-to-date coverage of gout and disease-modifying drugs. Learn how the study of biomarkers across populations can help you detect diseases earlier and with greater accuracy with a new chapter on epigenetics. Diagnose, monitor, and manage rheumatic disease more effectively with expanded information on the use of ultrasound and other imaging modalities.
The most authoritative, comprehensive, and clinically focused guide to operative thoracic surgery – updated with the latest techniques and technologies A Doody's Core Title for 2023! Sugarbaker’s Adult Chest Surgery is a thorough, hands-on guide to the practice of general thoracic surgery. The book covers the entire range of thoracic surgical techniques and management, along with crucial preoperative evaluation, staging, and postoperative strategies. Broad in scope and straightforward in style and presentation, this classic is an outstanding reference for any clinician in need of a comprehensive description of the clinical nature of general thoracic surgery. The focus of this third edition is on providing cutting-edge and up-to-date procedural and clinical management instructions in a field that is constantly changing. The previous edition highlighted minimally invasive, endoscopic, and robotic techniques, and this new edition will even further emphasize these developing technologies. More than 600 full color illustrations, drawn specifically for this book, enhance the text. Essential for residents preparing for a case, surgeons seeking management tips, and surgeons preparing for board recertification, Sugarbaker’s Adult Chest Surgery features a logical organization based on anatomy, and each section has an overview chapter summarizing the relevant anatomy, pathophysiology, and diagnostic and procedural options. Operations and diagnostic procedures are highlighted throughout the book in succinct, illustrated technique chapters.
This second edition of the landmark 1991 text, Basic Mechanisms of Pediatric Respiratory Disease reviews the importance of the integrations of molecular, cellular and physiologic strategies in the development of a new understanding of pediatric respiratory disorders. It provides state-of-the-art information about fundamental mechanisms underlying ......
Gabriel Stux, M.D., is chairman of the German Acupuncture Society D sseldorf, and director of the Acupuncture Center. He has practised and taught acupuncture worldwide since 1977. Dr. Stux is the author and co-author of several books on acupuncture in German. Bruce Pomeranz, M.D., Ph.D., has taught zoology at the University of Toronto since 1968 and physiology at the same university since 1982. He obtained his M.D. and C.M. at McGill University in 1961 and his Ph. D. at Harvard in 1967. He was Assistant Professor at M. I. T. from 1966 to 1968. Prof. Pomeranz has contributed 46 papers on acupuncture and, together with Dr. Stux, is author of the standard textbook: Acupuncture, Textbook and Atlas. Basics of Acupuncture is a unique introductory book; for the first time Western science and medicine are combined with traditional Chinese concepts. It begins with a review of the scientific basis of acupuncture and relevant research. An introduction to the philosophy and theory of traditional Chinese medicine is then followed by a detailed account of diagnosis and description of the Chinese system of channels, functional organs and most important acupuncture points. The remainder of the book is devoted to treatment, based on Western modes of diagnosis. The methods and applications of needling and moxibustion are described, and the most important points are given for frequently encountered diseases. From a review in a German journal: ..".this book was written by a physician for physicians and medical students alike and is characterized by a high degree of practical relevance...In addition to describing the 120 most important acupuncture points and depicting them in clear illustrations, this volume also provides a survey of the therapeutic principles and the selection of acupuncture points for the most important diseases...
This monograph explains what economic analysis is, why it is important, and forms it can take in policing and criminal justice. Costs are important in all forms of economic analysis but their collection tends to be partial and inadequate in capturing key information. A practical guide to the collection is therefore also provided.
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