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Cancer Immunotherapy

Chapter 31. Galectins: Key Players in the Tumor Microenvironment

By: Victoria Sundblad,Veronique Mathieu,Robert Kiss,Gabriel A. Rabinovich

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Cancer Immunotherapy

Chapter 31. Galectins: Key Players in the Tumor Microenvironment

By: Victoria Sundblad,Veronique Mathieu,Robert Kiss,Gabriel A. Rabinovich

Galectins are glycan-binding proteins implicated in intracellular signaling, cell–cell communication, cellular proliferation and survival. These endogenous lectins have emerged as key players in the tumor microenvironment. They are expressed and released by different cell types, including tumor, stromal, endothelial and immune cells. Galectins critically influence tumor progression by modulating tumor cell migration, invasiveness, angiogenesis and antitumor immune responses. Intracellularly, galectins modulate survival and proliferation and they interact with a variety of signaling pathways. Given these extracellular and intracellular functions and their regulated expression at sites of tumor growth and metastasis, galectins have stimulated great interest as relevant biomarkers and novel targets in cancer therapy.

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Page Count

56

Publisher

Elsevier Inc. Chapters

Published Date

ISBN 10

0128059273

ISBN 13

9780128059272

Advanced Therapy of Breast Disease

By: S. Eva Singletary,Geoffrey L. Robb,Gabriel N. Hortobagyi

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Advanced Therapy of Breast Disease

By: S. Eva Singletary,Geoffrey L. Robb,Gabriel N. Hortobagyi

The information surveyed in this volulme is designed to provide the clinician with an expert overview of the current state of the art in breast cancer management. It should provide at least a flavor of the major paradigm shift that is occurring in this rapidly evolving field. Breast cancer management is moving away from a "kill or cure" model and advancing toward a model focused on strategies of prevention and of long-term management of breast cancer as a chronic disease. The acceptance of this new paradigm by patients and clinicians alike will represent a major focus for the twenty-first century.

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Page Count

902

Publisher

PMPH-USA

Published Date

ISBN 10

1550092626

ISBN 13

9781550092622