Fundamentals of Body MRI—a new title in the Fundamentals of Radiology series—explains and defines key concepts in body MRI so you can confidently make radiologic diagnoses. Dr. Christopher G. Roth presents comprehensive guidance on body imaging—from the liver to the female pelvis—and discusses how physics, techniques, hardware, and artifacts affect results. This detailed and heavily illustrated reference will help you effectively master the complexities of interpreting findings from this imaging modality. Master MRI techniques for the entirety of body imaging, including liver, breast, male and female pelvis, and cardiovascular MRI. Avoid artifacts thanks to extensive discussions of considerations such as physics and parameter tradeoffs. Grasp visual nuances through numerous images and correlating anatomic illustrations.
Weaving together prescriptions with a series of cases, Systemic Change Management describes the value and how-to of a systemic or enterprise approach to organizational change. Each capability presented here promotes change, but when used together create synergies that magnify their individual impact within and between collaborating organizations.
“Badfellas” takes the reader behind the scenes to reveal what it is like to be a trial lawyer in justice’s great arena, the courts of America. Mr. Roth writes from the vantage point of an attorney who had been a prosecutor, defense attorney and civil litigant for more than 40 years. His “badfellas” include drug traffickers, organized criminals, terrorists, murders, a pimp, a pedophile priest, and a TV talk show villain. He chooses 7 of his most intriguing cases and trials to tell his compelling story: • “The Smuggler and the Terrorist Prince”: The prosecution of America’s most wanted drug smuggler who became a hostage aboard an airliner hijacked by Pakistani terrorists. • “Welcome to Palermo”: The prosecution of the first Sicilian Connection heroin importation case, where the top echelon of an entire international smuggling operation was dismantled in coordinated trials in New York and Italy. • “The Charity That Wasn’t”: The trial of a gang of incorrigible criminals and murderers which used a charity as a front for their drug organization. • “Hush Money”: A lawsuit involving a pedophile priest and the Catholic’s Church’s unsuccessful attempts to conceal the clergyman’s crimes. • “The Mouth That Roared”: The defense of a popular television personality who was charged with assaulting a gay rights activist on his show. • “Tony Montana and the Bird Dog”: The defense of an Atlantic City pimp accused of laundering money for a 25-year-old crack kingpin who fancied himself the “Tony Montana” of Queens. • “The Bad Side of Mansfield”: A DEA Agent who faced the travails of a modern-day Job, all orchestrated by a rogue drug informant whose deceitful conduct turned the criminal justice system upside down.
Assisted living is the fastest-growing alternative to skilled nursing care for frail older persons in the United States. The expectations, settings, and missions of these residences are varied, making it difficult for prospective residents and their families to anticipate what it would be like to live in them. This book is a unique portal into the real world of assisted living and the key issues facing consumers, providers, and policy makers. Drawing on in-depth interviews with residents, their family members, staffers, and administrators, Inside Assisted Living opens the window on day-to-day life in six different types of assisted living residence. From “Miss Helen at Valley Glen Home” to “Mr. Sidney at Laurel Ridge,” the detailed profiles of individuals show the commonalities among the residences while highlighting the positive and negative aspects of each. The voices of those living, visiting, and working in the homes clarify the important local (social relations, staff dynamics, leadership) and national (funding, regulation, aging-in-place) challenges presented by assisted living. Introductory and concluding chapters synthesize new findings that cross the six settings and reflect issues vital to all participants. The book also features an appendix detailing the research process involved in creating the profiles.
Annual soybean production in the U.S. is worth nearly $40 billion, valued for its oils and protein content. Many pathogens and pests cause significant soybean yield losses each year, but one of the top threats is sudden death syndrome (SDS). At least five fungal species cause soybean SDS globally, but only two have been found in the U.S.; Fusarium virguliforme and F. brasiliense. These soil-borne pathogens infect root tissues and cause root rot, with continued infection leading to foliar interveinal chlorosis, interveinal necrosis, leaf drop, and yield loss. The pathogens are strong saprophytes that can overwinter in soybean and corn residue, so successful management is difficult. Long-term crop rotations and seed treatments with fungicides show some efficacy, but these strategies can be costly for growers. Growers desire genetic resistance to SDS, but no soybean germplasm has shown 100% resistance to SDS to date. Therefore, the overall goals of projects presented in this dissertation were to help improve SDS management and explore the biology and genetics of F. virguliforme and F. brasiliense. To achieve these goals, I developed a risk prediction tool for integration with current SDS management strategies (Chapter 2). This study revealed that pathogen data collected from soil at-planting can be used to accurately model spatial distributions pathogens and model future SDS development and yield loss at a field level. This risk prediction study used a qPCR assay specific for F. virguliforme, but a similar qPCR assay for F. brasiliense did not exist. Therefore, I developed a qPCR assay that can distinguish F. brasiliense from close relatives (Chapter 3). This tool that can be used to generate SDS-prediction models for F. brasiliense and I predict will be valuable in diagnostic labs across the country to distinguish between these two species. To advance our understanding of the biology and genetics of these pathogens, I developed a new protoplast generation and transformation method to generate fluorescent strains of each pathogen (Chapter 4). This chapter is the first to report genetic transformation in F. brasiliense. Furthermore, I used the fluorescent strains to investigate the synergistic role of soil-borne nematodes in SDS (Chapter 5). The interactions between these fungal pathogens and nematodes in vitro show that F. virguliforme and F. brasiliense can colonize immobile nematodes, but suggest that they are not actively vectored into soybean roots by nematodes. The genetic mechanisms of SDS development are poorly understood, so I developed high quality genome sequences for F. virguliforme and F. brasiliense (Chapter 6) and investigated two recognized effector proteins; FvTox1 and FvNIS1 (Chapter 7). The genome assemblies developed here have significantly improved continuity, with improved genome assembly metrics like contig length (N50) and contig number. However, whole-genome alignments between F. virguliforme and F. brasiliense from soybean (Glycine max) or dry bean (Phaseolus vulgaris) did not reveal obvious mobile pathogenicity chromosomes that have been observed in the close relative F. oxysporum. However, these genome resources should facilitate discovery of new fungal effector proteins like FvTox1 and FvNIS1. Interestingly, my results show that FvNIS1 is able to induce a hypersensitive response in tobacco, while FvTox1 is not, suggesting a conserved mechanism between soybean and tobacco for FvNIS1 recognition. Overall, this work provides valuable tools for managing and studying SDS-causing fungi, while also revealing insights into the genetics and genomics of the SDS-causing pathogens F. virguliforme and F. brasiliense.
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