The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.
In the past ten years, there has been much progress in understanding the global dynamics of systems with several degrees-of-freedom. An important tool in these studies has been the theory of normally hyperbolic invariant manifolds and foliations of normally hyperbolic invariant manifolds. In recent years these techniques have been used for the development of global perturbation methods, the study of resonance phenomena in coupled oscillators, geometric singular perturbation theory, and the study of bursting phenomena in biological oscillators. "Invariant manifold theorems" have become standard tools for applied mathematicians, physicists, engineers, and virtually anyone working on nonlinear problems from a geometric viewpoint. In this book, the author gives a self-contained development of these ideas as well as proofs of the main theorems along the lines of the seminal works of Fenichel. In general, the Fenichel theory is very valuable for many applications, but it is not easy for people to get into from existing literature. This book provides an excellent avenue to that. Wiggins also describes a variety of settings where these techniques can be used in applications.
A unified treatment of resonant problems with special emphasis on the recently discovered phenomenon of homoclinic jumping. After a survey of the necessary background, the book develops a general finite dimensional theory of homoclinic jumping, illustrating it with examples. The main mechanism of chaos near resonances is discussed in both the dissipative and the Hamiltonian context, incorporating previously unpublished new results on universal homoclinic bifurcations near resonances, as well as on multi-pulse Silnikov manifolds. The results are applied to a variety of different problems, which include applications from beam oscillations, surface wave dynamics, nonlinear optics, atmospheric science and fluid mechanics.
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