Fumiaki Uchiumi's Books

Bidirectional Gene Promoters

Transcription system and chromosomal structure

By: Fumiaki Uchiumi

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Bidirectional Gene Promoters

Transcription system and chromosomal structure

By: Fumiaki Uchiumi

Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5'-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases. - Provides an overview of the process of transcription - Explains why there so many bidirectional promoters present in human genomes - Covers how the diverse biological functions of (non-coding RNAs) ncRNAs are controlled

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Page Count

236

Publisher

Elsevier

Published Date

ISBN 10

0128194618

ISBN 13

9780128194614

Bidirectional Gene Promoters

Transcription system and chromosomal structure

By: Fumiaki Uchiumi

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Bidirectional Gene Promoters

Transcription system and chromosomal structure

By: Fumiaki Uchiumi

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N/A

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Page Count

236

Publisher

Elsevier

Published Date

ISBN 10

0128194618

ISBN 13

9780128194614

Gene Expression and Regulation in Mammalian Cells - Transcription From General Aspects

By: Fumiaki Uchiumi

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Gene Expression and Regulation in Mammalian Cells - Transcription From General Aspects

By: Fumiaki Uchiumi

Central dogma"" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.

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Page Count

334

Published Date

ISBN 10

9535140957

ISBN 13

9789535140955

Book's by Fumiaki Uchiumi

Bidirectional Gene Promoters

Bidirectional Gene Promoters

Bidirectional Gene Promoters

Bidirectional Gene Promoters

Gene Expression and Regulation in Mammalian Cells - Transcription From General Aspects

Gene Expression and Regulation in Mammalian Cells - Transcription From General Aspects

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